Search Results - "Kreuzer, Steven M."

Coiled-Coil Response to Mechanical Force: Global Stability and Local Cracking by Kreuzer, Steven M., Elber, Ron

“…Coiled coils are important structural motifs formed by two or more amphipathic α-helices that twist into a supercoil. These motifs are found in a wide range of…”
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Catch bond-like kinetics of helix cracking: network analysis by molecular dynamics and milestoning by Kreuzer, Steven M, Moon, Tess J, Elber, Ron

“…The first events of unfolding of secondary structure under load are considered with Molecular Dynamics simulations and Milestoning analysis of a long helix…”
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Analyzing milestoning networks for molecular kinetics: definitions, algorithms, and examples by Viswanath, Shruthi, Kreuzer, Steven M, Cardenas, Alfredo E, Elber, Ron

“…Network representations are becoming increasingly popular for analyzing kinetic data from techniques like Milestoning, Markov State Models, and Transition Path…”
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Early Events in Helix Unfolding under External Forces: A Milestoning Analysis by Kreuzer, Steven M, Elber, Ron, Moon, Tess J

“…Initial events of helix breakage as a function of load are considered using molecular dynamics simulations and milestoning analysis. A helix length of ∼100…”
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Establishing the Biofidelity of a Multiphysics Finite Element Model of the Human Heart by Kreuzer, Steven M., Briant, Paul L., Ochoa, Jorge A.

“…Purpose Accelerating development of new therapeutic cardiac devices remains a clinical and technical priority. High-performance computing and the emergence of…”
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Pairing computational and scaled physical models to determine permeability as a measure of cellular communication in micro- and nano-scale pericellular spaces by Anderson, Eric J., Kreuzer, Steven M., Small, Oliver, Knothe Tate, Melissa L.

“…Cells, the living components of tissues, bathe in fluid. The pericellular fluid environment is a challenge to study due to the remoteness and complexity of its…”
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Mechanical Signal Transduction via Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Kreuzer, Steven M., Moon, Tess J.

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Propagation of Load Through Proteins via Steered Molecular Dynamics: Effect on Fluctuation Dynamics and Architecture by Kreuzer, Steven M., Liu, Chia-Cheng, Khatiblou, Esfandiar A., Marquez, Joel D., Moon, Tess J.

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Can a Reduced Dimension Interface Model be More Computationally Effective than a Docking Algorithm? by Liu, Chia-Cheng, Khatiblou, Esfandiar A., Zhou, Jun, Kreuzer, Steven M., Marquez, Joel D., Moon, Tess J.

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