Search Results - "Kreuz, Markus"

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups by Weller, Michael, Weber, Ruthild G., Willscher, Edith, Riehmer, Vera, Hentschel, Bettina, Kreuz, Markus, Felsberg, Jörg, Beyer, Ulrike, Löffler-Wirth, Henry, Kaulich, Kerstin, Steinbach, Joachim P., Hartmann, Christian, Gramatzki, Dorothee, Schramm, Johannes, Westphal, Manfred, Schackert, Gabriele, Simon, Matthias, Martens, Tobias, Boström, Jan, Hagel, Christian, Sabel, Michael, Krex, Dietmar, Tonn, Jörg C., Wick, Wolfgang, Noell, Susan, Schlegel, Uwe, Radlwimmer, Bernhard, Pietsch, Torsten, Loeffler, Markus, von Deimling, Andreas, Binder, Hans, Reifenberger, Guido

“…Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major challenge in terms of histological classification and clinical…”
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TP53 mutation and survival in aggressive B cell lymphoma by Zenz, Thorsten, Kreuz, Markus, Fuge, Maxi, Klapper, Wolfram, Horn, Heike, Staiger, Annette M, Winter, Doris, Helfrich, Hanne, Huellein, Jennifer, Hansmann, Martin-Leo, Stein, Harald, Feller, Alfred, Möller, Peter, Schmitz, Norbert, Trümper, Lorenz, Loeffler, Markus, Siebert, Reiner, Rosenwald, Andreas, Ott, German, Pfreundschuh, Michael, Stilgenbauer, Stephan

“…TP53 is mutated in 20-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial…”
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Classifying Germinal Center Derived Lymphomas-Navigate a Complex Transcriptional Landscape by Loeffler-Wirth, Henry, Kreuz, Markus, Schmidt, Maria, Ott, German, Siebert, Reiner, Binder, Hans

“…Classification of lymphoid neoplasms is based mainly on histologic, immunologic, and (rarer) genetic features. It has been supplemented by gene expression…”
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Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2 by Horn, Heike, Kohler, Christian, Witzig, Raphael, Kreuz, Markus, Leich, Ellen, Klapper, Wolfram, Hummel, Michael, Loeffler, Markus, Trümper, Lorenz, Spang, Rainer, Rosenwald, Andreas, Ott, German

“…A linear progression model of follicular lymphomas (FL) FL1, FL2 and FL3A has been favored, since FL3A often co-exist with an FL1/2 component. FL3B, in…”
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Distinct Immune Signatures Indicative of Treatment Response and Immune-Related Adverse Events in Melanoma Patients under Immune Checkpoint Inhibitor Therapy by Reschke, Robin, Gussek, Philipp, Boldt, Andreas, Sack, Ulrich, Köhl, Ulrike, Lordick, Florian, Gora, Thomas, Kreuz, Markus, Reiche, Kristin, Simon, Jan-Christoph, Ziemer, Mirjana, Kunz, Manfred

“…To identify potential early biomarkers of treatment response and immune-related adverse events (irAE), a pilot immune monitoring study was performed in stage…”
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Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults by Salaverria, Itziar, Philipp, Claudia, Oschlies, Ilske, Kohler, Christian W., Kreuz, Markus, Szczepanowski, Monika, Burkhardt, Birgit, Trautmann, Heiko, Gesk, Stefan, Andrusiewicz, Miroslaw, Berger, Hilmar, Fey, Miriam, Harder, Lana, Hasenclever, Dirk, Hummel, Michael, Loeffler, Markus, Mahn, Friederike, Martin-Guerrero, Idoia, Pellissery, Shoji, Pott, Christiane, Pfreundschuh, Michael, Reiter, Alfred, Richter, Julia, Rosolowski, Maciej, Schwaenen, Carsten, Stein, Harald, Trümper, Lorenz, Wessendorf, Swen, Spang, Rainer, Küppers, Ralf, Klapper, Wolfram, Siebert, Reiner

“…The prognosis of germinal center–derived B-cell (GCB) lymphomas, including follicular lymphoma and diffuse large-B-cell lymphoma (DLBCL), strongly depends on…”
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Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying by Loeffler-Wirth, Henry, Rade, Michael, Arakelyan, Arsen, Kreuz, Markus, Loeffler, Markus, Koehl, Ulrike, Reiche, Kristin, Binder, Hans

“…Anti-CD19 CAR-T cell immunotherapy is a hopeful treatment option for patients with B cell lymphomas, however it copes with partly severe adverse effects like…”
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A reliable transcriptomic risk-score applicable to formalin-fixed paraffin-embedded biopsies improves outcome prediction in localized prostate cancer by Rade, Michael, Kreuz, Markus, Borkowetz, Angelika, Sommer, Ulrich, Blumert, Conny, Füssel, Susanne, Bertram, Catharina, Löffler, Dennis, Otto, Dominik J, Wöller, Livia A, Schimmelpfennig, Carolin, Köhl, Ulrike, Gottschling, Ann-Cathrin, Hönscheid, Pia, Baretton, Gustavo B, Wirth, Manfred, Thomas, Christian, Horn, Friedemann, Reiche, Kristin

“…Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be…”
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The impact of SOCS1 mutations in diffuse large B‐cell lymphoma by Mellert, Kevin, Martin, Melanie, Lennerz, Jochen K., Lüdeke, Manuel, Staiger, Annette M., Kreuz, Markus, Löffler, Markus, Schmitz, Norbert, Trümper, Lorenz, Feller, Alfred C., Hartmann, Sylvia, Hansmann, Martin‐Leo, Klapper, Wolfram, Stein, Harald, Rosenwald, Andreas, Ott, German, Ziepert, Marita, Möller, Peter

“…Summary Mutations in SOCS1 are frequent in primary mediastinal B‐cell lymphoma and classical Hodgkin lymphoma. In the latter, SOCS1 mutations affect the length…”
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Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer by Schimmelpfennig, Carolin, Rade, Michael, Füssel, Susanne, Löffler, Dennis, Blumert, Conny, Bertram, Catharina, Borkowetz, Angelika, Otto, Dominik J, Puppel, Sven-Holger, Hönscheid, Pia, Sommer, Ulrich, Baretton, Gustavo B, Köhl, Ulrike, Wirth, Manfred, Thomas, Christian, Horn, Friedemann, Kreuz, Markus, Reiche, Kristin

“…Prostate cancer (PCa) is one of the most prevalent cancers worldwide. The clinical manifestations and molecular characteristics of PCa are highly variable…”
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A modular transcriptome map of mature B cell lymphomas by Loeffler-Wirth, Henry, Kreuz, Markus, Hopp, Lydia, Arakelyan, Arsen, Haake, Andrea, Cogliatti, Sergio B, Feller, Alfred C, Hansmann, Martin-Leo, Lenze, Dido, Möller, Peter, Müller-Hermelink, Hans Konrad, Fortenbacher, Erik, Willscher, Edith, Ott, German, Rosenwald, Andreas, Pott, Christiane, Schwaenen, Carsten, Trautmann, Heiko, Wessendorf, Swen, Stein, Harald, Szczepanowski, Monika, Trümper, Lorenz, Hummel, Michael, Klapper, Wolfram, Siebert, Reiner, Loeffler, Markus, Binder, Hans

“…Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the…”
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Characterization of genomic imbalances in diffuse large B‐cell lymphoma by detailed SNP‐chip analysis by Scholtysik, René, Kreuz, Markus, Hummel, Michael, Rosolowski, Maciej, Szczepanowski, Monika, Klapper, Wolfram, Loeffler, Markus, Trümper, Lorenz, Siebert, Reiner, Küppers, Ralf

“…The pathogenesis of diffuse large B‐cell lymphomas (DLBCL) is only partly understood. We analyzed 148 DLBCL by single nucleotide polymorphism (SNP)‐chips to…”
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The PCBP1 gene encoding poly(rc) binding protein i is recurrently mutated in Burkitt lymphoma by Wagener, Rabea, Aukema, Sietse M., Schlesner, Matthias, Haake, Andrea, Burkhardt, Birgit, Claviez, Alexander, Drexler, Hans G., Hummel, Michael, Kreuz, Markus, Loeffler, Markus, Rosolowski, Maciej, López, Cristina, Möller, Peter, Richter, Julia, Rohde, Marius, Betts, Matthew J., Russell, Robert B., Bernhart, Stephan H., Hoffmann, Steve, Rosenstiel, Philip, Schilhabel, Markus, Szczepanowski, Monika, Trümper, Lorenz, Klapper, Wolfram, Siebert, Reiner

“…The genetic hallmark of Burkitt lymphoma is the translocation t(8;14)(q24;q32), or one of its light chain variants, resulting in IG‐MYC juxtaposition. However,…”
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Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas by Scholtysik, René, Nagel, Inga, Kreuz, Markus, Vater, Inga, Giefing, Maciej, Schwaenen, Carsten, Wessendorf, Swen, Trümper, Lorenz, Loeffler, Markus, Siebert, Reiner, Küppers, Ralf

“…A single nucleotide polymorphism‐chip analysis of 98 cases of aggressive B‐cell lymphomas revealed a recurrent deletion at 19p13 in nine of the cases. Six…”
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Detection of genomic aberrations in molecularly defined Burkitt’s lymphoma by array-based, high resolution, single nucleotide polymorphism analysis by SCHOLTYSIK, Rene, KREUZ, Markus, STEIN, Harald, THORNS, Christoph, TRÜMPER, Lorenz, VATER, Inga, WESSENDORF, Swen, ZENZ, Thorsten, SIEBERT, Reiner, KÜPPERS, Ralf, KLAPPER, Wolfram, BURKHARDT, Birgit, FELLER, Alfred C, HUMMEL, Michael, LOEFFLER, Markus, ROSOLOWSKI, Maciej, SCHWAENEN, Carsten, SPANG, Rainer

“…Knowledge about the genetic lesions that occur in Burkitt's lymphoma, besides the pathognomonic IG-MYC translocations, is limited. Thirty-nine…”
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Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma by Szczepanowski, Monika, Masqué-Soler, Neus, Schlesner, Matthias, Haake, Andrea, Richter, Julia, Wagener, Rabea, Burkhardt, Birgit, Kreuz, Markus, Siebert, Reiner, Klapper, Wolfram

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MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians by Bittenbring, Joerg, Parisot, Frédérique, Wabo, Alain, Mueller, Monika, Kerschenmeyer, Lynn, Kreuz, Markus, Truemper, Lorenz, Landt, Olfert, Menzel, Alain, Pfreundschuh, Michael, Roemer, Klaus

“…SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a…”
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Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma by NIELÄNDER, Inga, MARTIN-SUBERO, José I, MARTINEZ-CLIMENT, José A, DREYLING, Martin, ARNOLD, Norbert, SIEBERT, Reiner, WAGNER, Florian, BAUDIS, Michael, CESK, Stefan, HARDER, Lana, HASENCLEVER, Dirk, KLAPPER, Wolfram, KREUZ, Markus, POTT, Christiane

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The role of HPV RNA transcription, immune response‐related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer by Wichmann, Gunnar, Rosolowski, Maciej, Krohn, Knut, Kreuz, Markus, Boehm, Andreas, Reiche, Anett, Scharrer, Ulrike, Halama, Dirk, Bertolini, Julia, Bauer, Ulrike, Holzinger, Dana, Pawlita, Michael, Hess, Jochen, Engel, Christoph, Hasenclever, Dirk, Scholz, Markus, Ahnert, Peter, Kirsten, Holger, Hemprich, Alexander, Wittekind, Christian, Herbarth, Olf, Horn, Friedemann, Dietz, Andreas, Loeffler, Markus

“…Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status, gene expression patterns, and mutated candidate genes may…”
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The genomic and transcriptional landscape of primary central nervous system lymphoma by Radke, Josefine, Ishaque, Naveed, Koll, Randi, Gu, Zuguang, Schumann, Elisa, Sieverling, Lina, Uhrig, Sebastian, Hübschmann, Daniel, Toprak, Umut H., López, Cristina, Hostench, Xavier Pastor, Borgoni, Simone, Juraeva, Dilafruz, Pritsch, Fabienne, Paramasivam, Nagarajan, Balasubramanian, Gnana Prakash, Schlesner, Matthias, Sahay, Shashwat, Weniger, Marc, Pehl, Debora, Radbruch, Helena, Osterloh, Anja, Korfel, Agnieszka, Misch, Martin, Onken, Julia, Faust, Katharina, Vajkoczy, Peter, Moskopp, Dag, Wang, Yawen, Jödicke, Andreas, Trümper, Lorenz, Anagnostopoulos, Ioannis, Lenze, Dido, Küppers, Ralf, Hummel, Michael, Schmitt, Clemens A., Wiestler, Otmar D., Wolf, Stephan, Unterberg, Andreas, Eils, Roland, Herold-Mende, Christel, Brors, Benedikt, Siebert, Reiner, Wiemann, Stefan, Heppner, Frank L.

“…Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS)…”
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