Search Results - "Kreuwel, Huub T. C"

The Apoptotic Pathway Contributing to the Deletion of Naive CD8 T Cells during the Induction of Peripheral Tolerance to a Cross-Presented Self-Antigen by Redmond, William L, Wei, Cheng-Hong, Kreuwel, Huub T. C, Sherman, Linda A

“…The maintenance of T cell tolerance in the periphery proceeds through several mechanisms, including anergy, immuno-regulation, and deletion via apoptosis. We…”
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Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease by Rogers, Stanley J, Cello, John P, Horn, Jan K, Siperstein, Allan E, Schecter, William P, Campbell, Andre R, Mackersie, Robert C, Rodas, Alex, Kreuwel, Huub T C, Harris, Hobart W

“…To compare outcome parameters for good-risk patients with classic signs, symptoms, and laboratory and abdominal imaging features of cholecystolithiasis and…”
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CD8+ T Cell Tolerance in Nonobese Diabetic Mice Is Restored by Insulin-Dependent Diabetes Resistance Alleles by Martinez, Xavier, Kreuwel, Huub T. C, Redmond, William L, Trenney, Rebecca, Hunter, Kara, Rosen, Hugh, Sarvetnick, Nora, Wicker, Linda S, Sherman, Linda A

“…Although candidate genes controlling autoimmune disease can now be identified, a major challenge that remains is defining the resulting cellular events…”
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Ontogeny of T Cell Tolerance to Peripherally Expressed Antigens by Morgan, David J., Kurts, Christian, Huub T. C. Kreuwel, Holst, Karen L., Heath, William R., Sherman, Linda A.

“…Transgenic expression of the influenza virus hemagglutinin (HA) in the pancreatic islet β cells of InsHA mice leads to peripheral tolerance of HA-specific T…”
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Mechanisms mediating anti-CD3 antibody efficacy: insights from a mathematical model of type 1 diabetes by Young, Daniel L, Ramanujan, Saroja, Kreuwel, Huub T C, Whiting, Chan Chung, Gadkar, Kapil G, Shoda, Lisl K M

“…Anti-CD3 antibody therapy, a promising clinical approach for the treatment of type 1 diabetes (T1D), was investigated using a mathematical model of T1D in the…”
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Hospital economic impact from hemostatic matrix usage in cardiac surgery by Tackett, Scott M, Sugarman, Rebecca, Kreuwel, Huub T C, Alvarez, Piedad, Nasso, Giuseppe

“…Improved health outcomes can result in economic savings for hospitals and payers. While effectiveness of topical hemostatic agents in cardiac surgery has been…”
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A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation by Shoda, Lisl K.M., Young, Daniel L., Ramanujan, Saroja, Whiting, Chan C., Atkinson, Mark A., Bluestone, Jeffrey A., Eisenbarth, George S., Mathis, Diane, Rossini, Aldo A., Campbell, Scott E., Kahn, Richard, Kreuwel, Huub T.C.

“…Type 1 diabetes (T1D) animal models such as the nonobese diabetic (NOD) mouse have improved our understanding of disease pathophysiology, but many candidate…”
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Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens by Morgan, David J, Kreuwel, Huub T. C, Sherman, Linda A

“…Expression of transgene-encoded proteins in the pancreatic islets can cause peripheral deletion of T cells. However, tolerance has not been observed in all…”
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Comparison of Hemostatic Matrix and Standard Hemostasis in Patients Undergoing Primary TKA by Comadoll, James L, Comadoll, Shea, Hutchcraft, Audrey, Krishnan, Sangeeta, Farrell, Kelly, Kreuwel, Huub T C, Bechter, Mark

“…Bleeding after total knee arthroplasty increases the risk of pain, delayed rehabilitation, blood transfusion, and transfusion-associated complications. The…”
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Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity by Morgan, David J, Kreuwel, Huub T. C, Fleck, Shonna, Levitsky, Hyam I, Pardoll, Drew M, Sherman, Linda A

“…To determine how self-tolerance can alter the ability of the immune system to respond against tumor-associated Ags that are also expressed by normal tissue, we…”
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The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes by Zheng, Yanan, Kreuwel, Huub T C, Young, Daniel L, Shoda, Lisl K M, Ramanujan, Saroja, Gadkar, Kapil G, Atkinson, Mark A, Whiting, Chan C

“…Type 1 diabetes is a complex, multifactorial disease characterized by T cell-mediated autoimmune destruction of insulin-secreting pancreatic beta cells. To…”
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Memory CD8 + T Cells Undergo Peripheral Tolerance by Kreuwel, Huub T.C., Aung, Sandra, Silao, Cheryl, Sherman, Linda A.

“…Memory T cells differ from naive T cells in that they respond more rapidly and in greater numbers. In addition, memory T cells are generally believed to be…”
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Dosing and timing effects of anti-CD40L therapy: predictions from a mathematical model of type 1 diabetes by Gadkar, Kapil G, Shoda, Lisl K M, Kreuwel, Huub T C, Ramanujan, Saroja, Zheng, Yanan, Whiting, Chan C, Young, Daniel L

“…Several publications describing the use of anti-CD40L monoclonal antibodies (anti-CD40L) for the treatment of type 1 diabetes in non-obese diabetic (NOD) mice…”
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Comparing the Relative Role of Perforin/Granzyme Versus Fas/Fas Ligand Cytotoxic Pathways in CD8+ T Cell-Mediated Insulin-Dependent Diabetes Mellitus by Kreuwel, Huub T. C, Morgan, David J, Krahl, Troy, Ko, Alice, Sarvetnick, Nora, Sherman, Linda A

“…CD8+ cytotoxic T cells play a critical role in initiating insulin-dependent diabetes mellitus. The relative contribution of each of the major cytotoxic…”
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Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic Mice by Kreuwel, Huub T. C, Biggs, Judith A, Pilip, Ingrid M, Pamer, Eric G, Lo, David, Sherman, Linda A

“…Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that involves participation of both CD4+ and CD8+ T cells. Previous studies have…”
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Dosing and Timing Effects of Anti-CD40L Therapy by GADKAR, KAPIL G., SHODA, LISL K. M., KREUWEL, HUUB T. C., RAMANUJAN, SAROJA, ZHENG, YANAN, WHITING, CHAN C., YOUNG, DANIEL L.

“…:  Several publications describing the use of anti‐CD40L monoclonal antibodies (anti‐CD40L) for the treatment of type 1 diabetes in non‐obese diabetic (NOD)…”
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The Virtual NOD Mouse by ZHENG, YANAN, KREUWEL, HUUB T. C., YOUNG, DANIEL L., SHODA, LISL K. M., RAMANUJAN, SAROJA, GADKAR, KAPIL G., ATKINSON, MARK A., WHITING, CHAN C.

“…:  Type 1 diabetes is a complex, multifactorial disease characterized by T cell–mediated autoimmune destruction of insulin‐secreting pancreatic β cells. To…”
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The role of fas-fasl in CD8+ T-cell-mediated insulin-dependent diabetes mellitus (IDDM) by KREUWEL, Huub T. C, SHERMAN, Linda A

“…In the past few years a number of studies have evaluated the contributions of different cytolytic pathways in the autoimmune destruction of pancreatic beta…”
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Self-tolerance and the composition of T cell repertoire by Sherman, L A, Morgan, D J, Nugent, C T, Hernandez, F J, Kreuwel, H T, Murtaza, A, Ko, A, Biggs, J

“…T cell recognition of self-major histocompatibility complex-peptide complexes dictates the composition of the T cell receptor repertoire. Research projects in…”
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Comprehensive Analysis of Time-Dependent Effects for Treatment Outcomes in the Non-Obese Diabetic Mouse by young, Daniel L, Chung, Chan D, Kreuwel, Huub T C, Ramanujan, Saroja

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