Search Results - "Kreutzer, Adam G"

X‑ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16–36 by Salveson, Patrick J, Spencer, Ryan K, Kreutzer, Adam G, Nowick, James S

“…The assembly of the β-amyloid peptide, Aβ, into soluble oligomers is associated with neurodegeneration in Alzheimer’s disease. The Aβ oligomers are thought to…”
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A Hexamer of a Peptide Derived from Aβ16–36 by Kreutzer, Adam G, Spencer, Ryan K, McKnelly, Kate J, Yoo, Stan, Hamza, Imane L, Salveson, Patrick J, Nowick, James S

“…The absence of high-resolution structures of amyloid oligomers constitutes a major gap in our understanding of amyloid diseases. A growing body of evidence…”
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Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display by Suire, Caitlin N, Nainar, Sarah, Fazio, Michael, Kreutzer, Adam G, Paymozd-Yazdi, Tara, Topper, Caitlyn L, Thompson, Caroline R, Leissring, Malcolm A

“…Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which…”
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Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue by Kreutzer, Adam G., Parrocha, Chelsea Marie T., Haerianardakani, Sepehr, Guaglianone, Gretchen, Nguyen, Jennifer T., Diab, Michelle N., Yong, William, Perez-Rosendahl, Mari, Head, Elizabeth, Nowick, James S.

“…Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are important tools in Alzheimer’s disease research and have emerged as…”
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Elucidating the Structures of Amyloid Oligomers with Macrocyclic β‑Hairpin Peptides: Insights into Alzheimer’s Disease and Other Amyloid Diseases by Kreutzer, Adam G, Nowick, James S

“…Conspectus In the more than a century since its identification, Alzheimer’s disease has become the archetype of amyloid diseases. The first glimpses of the…”
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Supramolecular Interactions of Teixobactin Analogues in the Crystal State by Yang, Hyunjun, Kreutzer, Adam G., Nowick, James S.

“…This Note presents the X-ray crystallographic structure of the N-methylated teixobactin analogue N-Me-d-Gln4,Lys10-teixobactin (1). Eight peptide molecules…”
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Exploring amyloid oligomers with peptide model systems by Samdin, Tuan D., Kreutzer, Adam G., Nowick, James S.

“…The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid…”
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Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ by Kreutzer, Adam G, Yoo, Stan, Spencer, Ryan K, Nowick, James S

“…Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in Alzheimer’s disease. Mounting evidence suggests that Aβ…”
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β‑Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides by Ruttenberg, Sarah M., Kreutzer, Adam G., Truex, Nicholas L., Nowick, James S.

“…Amyloid-β (Aβ) forms heterogeneous oligomers, which are implicated in the pathogenesis of Alzheimer’s disease (AD). Many Aβ oligomers consist of β-hairpin…”
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Correction to “β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides” by Ruttenberg, Sarah M., Kreutzer, Adam G., Truex, Nicholas L., Nowick, James S.

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X‑ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17–36 β‑Hairpin by Kreutzer, Adam G, Hamza, Imane L, Spencer, Ryan K, Nowick, James S

“…High-resolution structures of oligomers formed by the β-amyloid peptide Aβ are needed to understand the molecular basis of Alzheimer’s disease and develop…”
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An Efficient Method for the Expression and Purification of Aβ(M1–42) by Yoo, Stan, Zhang, Sheng, Kreutzer, Adam G, Nowick, James S

“…Advances in amyloid research rely on improved access to the β-amyloid peptide, Aβ. N-Terminal methionine-extended Aβ, Aβ­(M1–42), is a readily expressed and…”
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Synthesis and study of macrocyclic β-hairpin peptides for investigating amyloid oligomers by Guaglianone, Gretchen, Kreutzer, Adam G, Nowick, James S

“…Chemically constrained peptides that self-assemble can be used to better understand the molecular basis of amyloid diseases. The formation of small assemblies…”
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Repurposing Triphenylmethane Dyes to Bind to Trimers Derived from Aβ by Salveson, Patrick J, Haerianardakani, Sepehr, Thuy-Boun, Alexander, Yoo, Stan, Kreutzer, Adam G, Demeler, Borries, Nowick, James S

“…Soluble oligomers of the β-amyloid peptide, Aβ, are associated with the progression of Alzheimer’s disease. Although many small molecules bind to these…”
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Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists by Zhang, Sheng, Krumberger, Maj, Morris, Michael A., Parrocha, Chelsea Marie T., Kreutzer, Adam G., Nowick, James S.

“…This paper describes the structure-based design of a preliminary drug candidate against COVID-19 using free software and publicly available X-ray…”
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A cyclic peptide inhibitor of the SARS-CoV-2 main protease by Kreutzer, Adam G., Krumberger, Maj, Diessner, Elizabeth M., Parrocha, Chelsea Marie T., Morris, Michael A., Guaglianone, Gretchen, Butts, Carter T., Nowick, James S.

“…This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (Mpro). The cyclic peptide inhibitor…”
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Controlling the Oligomerization State of Aβ-Derived Peptides with Light by Salveson, Patrick J, Haerianardakani, Sepehr, Thuy-Boun, Alexander, Kreutzer, Adam G, Nowick, James S

“…A key challenge in studying the biological and biophysical properties of amyloid-forming peptides is that they assemble to form heterogeneous mixtures of…”
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Effects of Familial Alzheimer’s Disease Mutations on the Assembly of a β‑Hairpin Peptide Derived from Aβ16–36 by McKnelly, Kate J, Kreutzer, Adam G, Howitz, William J, Haduong, Katelyn, Yoo, Stan, Hart, Candace, Nowick, James S

“…Familial Alzheimer’s disease (FAD) is associated with mutations in the β-amyloid peptide (Aβ) or the amyloid precursor protein (APP). FAD mutations of Aβ were…”
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A β-barrel-like tetramer formed by a β-hairpin derived from Aβ by Samdin, Tuan D, Jones, Chelsea R, Guaglianone, Gretchen, Kreutzer, Adam G, Freites, J. Alfredo, Wierzbicki, Micha, Nowick, James S

“…β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three different alignments of β-hairpins have been observed in the…”
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Structure–Activity Relationship Studies of the Peptide Antibiotic Clovibactin by Brunicardi, Jackson E. H., Griffin, James H., Ferracane, Michael J., Kreutzer, Adam G., Small, Jeramiah, Mendoza, Ana-Teresa, Ziller, Joseph W., Nowick, James S.

“…Our laboratory reported the chemical synthesis and stereochemical assignment of the recently discovered peptide antibiotic clovibactin. The current paper…”
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