Search Results - "Kreutter, David"

Mapping the space of chemical reactions using attention-based neural networks by Schwaller, Philippe, Probst, Daniel, Vaucher, Alain C., Nair, Vishnu H., Kreutter, David, Laino, Teodoro, Reymond, Jean-Louis

“…Organic reactions are usually assigned to classes containing reactions with similar reagents and mechanisms. Reaction classes facilitate the communication of…”
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The virtual consulting company: Teaching statistical consulting through simulated experience by Shilane, David, Lorenzetti, Nicole L., Di Crecchio, Nicole, Kreutter, David K.

“…Training students to become effective consultants is an important goal of statistical education. The pedagogical models include drop‐in consulting, workshops,…”
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Chemoenzymatic multistep retrosynthesis with transformer loops by Kreutter, David, Reymond, Jean-Louis

“…Integrating enzymatic reactions into computer-aided synthesis planning (CASP) should help devise more selective, economical, and greener synthetic routes…”
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Predicting enzymatic reactions with a molecular transformer by Kreutter, David, Schwaller, Philippe, Reymond, Jean-Louis

“…The use of enzymes for organic synthesis allows for simplified, more economical and selective synthetic routes not accessible to conventional reagents…”
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Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search by Kreutter, David, Reymond, Jean-Louis

“…Computer-aided synthesis planning (CASP) aims to automatically learn organic reactivity from literature and perform retrosynthesis of unseen molecules. CASP…”
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A comparative analysis of contractual risks in statistical consulting by Shilane, David, Lorenzetti, Nicole L., Kreutter, David K.

“…This study enumerates and compares the risks and rewards of different forms of statistical consulting contracts. We assess three different contract models:…”
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Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice by STEVENSON, R. W, HUTSON, N. J, GIBBS, E. M, KREUTTER, D. K, KRUPP, M. N, VOLKMANN, R. A, HOLLAND, G. F, EGGLER, J. F, CLARK, D. A, MCPHERSON, R. K, HALL, K. L, DANBURY, B. H

“…The effects of CP 68722 (racemic englitazone) were examined in ob/ob mice, in adipocytes and soleus muscles from ob/ob mice, and in 3T3-L1 adipocytes…”
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Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis by STEVENSON, R. W, KREUTTER, D. K, ANDREWS, K. M, GENEREUX, P. E, GIBBS, E. M

“…The aim of this study was to compare the effects of insulin and the insulinomimetic agent, englitazone, on functional end points and putative mediators of…”
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The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet by STEVENSON, R. W, MCPHERSON, R. K, PERSSON, L. M, GENEREUX, P. E, SWICK, A. G, SPITZER, J, HERBST, J. J, ANDREWS, K. M, KREUTTER, D. K, GIBBS, E. M

“…The effects of englitazone in male Wistar rats fed a high-fat diet (59% of calories as fat) were compared with control rats fed a high-carbohydrate diet (69%…”
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insulinlike activity of new antidiabetic agent CP 68722 in 3T3-L1 adipocytes by KREUTTER, D. K, ANDREWS, K. M, GIBBS, A. E. ML, HUTSON, N. J, STEVENSON, R. W

“…We examined the in vitro effects of CP 68722, a novel antidiabetic agent, in 3T3-L1 adipocytes. CP 68722 stimulated 2-deoxyglucose uptake in the absence of…”
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Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents by Clark, David A, Goldstein, Steven W, Volkmann, Robert A, Eggler, James F, Holland, Gerald F, Hulin, Bernard, Stevenson, Ralph W, Kreutter, David K, Gibbs, E. Michael

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Spontaneous Diabetes Mellitus in Transgenic Mice Expressing Human Islet Amyloid Polypeptide by Janson, Juliette, Soeller, Walter C., Roche, Patrick C., Nelson, Robin T., Torchia, Anthony J., Kreutter, David K., Butler, Peter C.

“…The islet in non-insulin-dependent diabetes mellitus (NIDDM) is characterized by loss of β cells and large local deposits of amyloid derived from the 37-amino…”
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Distribution of β3-adrenoceptor mRNA in human tissues by BERKOWITZ, D. E, NARDONE, N. A, SMILEY, R. M, PRICE, D. T, KREUTTER, D. K, FREMEAU, R. T, SCHWINN, D. A

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Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide by Soeller, W C, Janson, J, Hart, S E, Parker, J C, Carty, M D, Stevenson, R W, Kreutter, D K, Butler, P C

“…Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide. W C Soeller , J Janson , S E Hart , J C Parker , M D Carty…”
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Mapping the Space of Chemical Reactions Using Attention-Based Neural Networks by Schwaller, Philippe, Probst, Daniel, Vaucher, Alain C, Nair, Vishnu H, Kreutter, David, Laino, Teodoro, Reymond, Jean-Louis

“…Organic reactions are usually assigned to classes containing reactions with similar reagents and mechanisms. Reaction classes facilitate the communication of…”
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Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction by M Couce, L A Kane, T D O'Brien, J Charlesworth, W Soeller, J McNeish, D Kreutter, P Roche, P C Butler

“…Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction. M…”
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Human islet amyloid polypeptide expression in COS-1 cells. A model of intracellular amyloidogenesis by O'Brien, TD, Butler, PC, Kreutter, DK, Kane, LA, Eberhardt, NL

“…Non-insulin-dependent diabetes mellitus is characterized by concurrent loss of beta-cells and deposition of islet amyloid derived from islet amyloid…”
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Adrenergic regulation of the mitochondrial uncoupling protein gene in brown fat tumor cells by Kozak, U C, Held, W, Kreutter, D, Kozak, L P

“…A tumor appeared on the back of a transgenic mouse carrying the SV40 T-antigen under control of a mouse major urinary protein promoter. High levels of mRNA for…”
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Islet amyloid-associated diabetes in obese Avy/A mice expressing human islet amyloid polypeptide by SOELLER, W. C, JANSON, J, HART, S. E, PARKER, J. C, CARTY, M. D, STEVENSON, R. W, KREUTTER, D. K, BUTLER, P. C

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Age-related changes in amylin secretion by Edwards, Beatriz J., Perry, Horace M., Kaiser, Fran E., Morley, John E., Kraenzle, Dale, Kreutter, David K., Stevenson, Ralph W.

“…Amylin (islet amyloid polypeptide) is a recently identified pancreatic peptide. It has been shown to affect glucose metabolism both in vitro and in vivo. A…”
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