Search Results - "Kretzner, Leo"

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer by Gaur, Shikha, PhD, Wang, Yafan, MS, MPH, Kretzner, Leo, PhD, Chen, Linling, MS, Yen, Terence, Wu, Xiwei, PhD, Yuan, Yate-Ching, PhD, Davis, Mark, PhD, Yen, Yun, MD, PhD

“…Abstract CRLX101 is a nanopharmaceutical consisting of cyclodextrin-based polymer molecule and camptothecin. The CRLX101 nanoparticle is designed to…”
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The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph− acute lymphoblastic leukemia cells by Scuto, Anna, Kirschbaum, Mark, Kowolik, Claudia, Kretzner, Leo, Juhasz, Agnes, Atadja, Peter, Pullarkat, Vinod, Bhatia, Ravi, Forman, Stephen, Yen, Yun, Jove, Richard

“…We investigated the mechanism of action of LBH589, a novel broad-spectrum HDAC inhibitor belonging to the hydroxamate class, in Philadelphia…”
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Preclinical Results of Camptothecin-Polymer Conjugate (IT-101) in Multiple Human Lymphoma Xenograft Models by Numbenjapon, Tontanai, Wang, Jianyi, Colcher, David, Schluep, Thomas, Davis, Mark E, Duringer, Julienne, Kretzner, Leo, Yen, Yun, Forman, Stephen J, Raubitschek, Andrew

“…Purpose: Camptothecin (CPT) has potent broad-spectrum antitumor activity by inhibiting type I DNA topoisomerase (DNA topo I). It has not been used clinically…”
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Human non-CG methylation: Are human stem cells plant-like? by Dyachenko, Olga V., Schevchuk, Tara V., Kretzner, Leo, Buryanov, Yaroslav I., Smith, Steven S.

“…Non-CG methylation is well characterized in plants, where it appears to play a role in gene silencing and genomic imprinting. Although strong evidence for the…”
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Myc and Max proteins possess distinct transcriptional activities by Kretzner, Leo, Blackwood, Elizabeth M, Eisenman, Robert N

“…The Myc family proteins are thought to be involved in transcription because they have both a carboxy-terminal basic-helix-loop-helix-zipper (bHLH-Z) domain,…”
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Sequence-Specific DNA Binding by the c-Myc Protein by Blackwell, T. Keith, Kretzner, Leo, Blackwood, Elizabeth M., Eisenman, Robert N., Weintraub, Harold

“…While it has been known for some time that the c-Myc protein binds to random DNA sequences, no sequence-specific binding activity has been detected. At its…”
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Myc and Max function as a nucleoprotein complex by Blackwood, E M, Kretzner, L, Eisenman, R N

“…The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins…”
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Characterization of the Chicken CTCF Genomic Locus, and Initial Study of the Cell Cycle-regulated Promoter of the Gene by Klenova, Elena M., Fagerlie, Sara, Filippova, Galina N., Kretzner, Leo, Goodwin, Graham H., Loring, Gilbert, Neiman, Paul E., Lobanenkov, Victor V.

“…CTCF is a multifunctional transcription factor encoded by a novel candidate tumor suppressor gene (Filippova, G. N., Lindblom, A., Meinke, L. J., Klenova, E…”
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Combining Histone Deacetylase Inhibitor Vorinostat with Aurora Kinase Inhibitors Enhances Lymphoma Cell Killing with Repression of c-Myc, hTERT, and microRNA Levels by KRETZNER, Leo, SCUTO, Anna, DINO, Pamela M, KOWOLIK, Claudia M, JUN WU, VENTURA, Patrick, JOVE, Richard, FORMAN, Stephen J, YUN YEN, KIRSCHBAUM, Mark H

“…MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G(2)-M cell-cycle arrest. Growth and survival of multiple lymphoma cell lines were…”
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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival by Scuto, A, Krejci, P, Popplewell, L, Wu, J, Wang, Y, Kujawski, M, Kowolik, C, Xin, H, Chen, L, Kretzner, L, Yu, H, Wilcox, W R, Yen, Y, Forman, S, Jove, R

“…IL-6 and downstream JAK-dependent signaling pathways have critical roles in the pathophysiology of multiple myeloma (MM). We investigated the effects of a…”
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The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc by Li, Jun, Kretzner, Leo

“…A major prognostic marker for neuroblastoma (Nb) is N-myc gene amplification, which predicts a poor clinical outcome. We sought genes differentially expressed…”
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Combination Therapy with the Histone Deacetylase Inhibitor Vorinostat Plus the Novel Aurora Kinase A Inhibitor MK-5108 Leads to Enhanced Lymphoma Cell Death Due to Acetylation of p53 and Repression of c-Myc, hTERT, and miRNA Levels by Kretzner, Leo, Scuto, Anna, Claudia, Kowolik, Jove, Richard, Forman, Stephen J, Yen, Yun, Kirschbaum, Mark

“…Abstract 1690 Poster Board I-716 Patients with relapsed or refractory Hodgkin (HL) and Non Hodgkin Lymphoma (NHL) have few options after salvage therapy and…”
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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity by Ayer, D E, Kretzner, L, Eisenman, R N

“…Myc family proteins appear to function through heterodimerization with the stable, constitutively expressed bHLH-Zip protein, Max. To determine whether Max…”
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Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and micro-RNA levels by Kretzner, Leo, Scuto, Anna, Dino, Pamela M., Kowolik, Claudia M., Wu, Jun, Ventura, Patrick, Jove, Richard, Forman, Stephen J., Yen, Yun, Kirschbaum, Mark H.

“…MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G2/M cell cycle arrest. Growth and survival of multiple lymphoma cell lines were…”
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Combination Therapy with Histone Deacetylase Inhibitor Vorinostat Plus Aurora Kinase Inhibitor MK-0457 Leads to Enhanced Lymphoma Cell Killing with Stabilization of p53 and Repression of C-Myc, hTERT, and Myc-Responsive miRNAs by Kretzner, Leo, Scuto, Anna, Jove, Richard, Forman, Stephen J., Yen, Yun, Kirschbaum, Mark

“…Background: Patients with relapsed or refractory Hodgkin (HL) and Non Hodgkin Lymphoma (NHL) have few therapeutic options after salvage therapy and transplant,…”
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Prostate cancer molecular markers GSTP1 and hTERT in expressed prostatic secretions as predictors of biopsy results by Crocitto, Laura E., Korns, Darlynn, Kretzner, Leo, Shevchuk, Taras, Blair, Sarah L., Wilson, Timothy G., Ramin, Soroush A., Kawachi, Mark H., Smith, Steven S.

“…To develop noninvasive diagnostic tools for the early detection of prostate cancer (PCa). Current screening for PCa lacks sensitivity and specificity. Two…”
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Combination of the Histone Deacetylase Inhibitor Vorinostat and Dasatinib Increases Apoptosis in Bcr-abl+ Cells and Reverses Changes Associated with CML Progression by Kretzner, Leo, Scuto, Anna, Juhasz, Agnes, Jove, Richard, Yen, Yun, Forman, Stephen J., Kirschbaum, Mark

“…Chronic myelogenous leukemia (CML) is associated with the bcr-abl fusion gene product, a constitutively active non-receptor tyrosine kinase driving cell…”
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Binding of myc proteins to canonical and noncanonical DNA sequences by BLACKWELL, T. K, JING HUANG, AVERIL MA, KRETZNER, L, ALT, F. W, EISENMAN, R. N, WEINTRAUB, H

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product by QI LUO, JUN LI, CENKCI, Belgin, KRETZNER, Leo

“…Myc proteins are transcriptional activators, but also repress transcription through initiator (Inr) elements. Repression requires the conserved Myc Box II, but…”
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Transgene-induced CCWGG methylation does not alter CG methylation patterning in human kidney cells by Shevchuk, Taras, Kretzner, Leo, Munson, Kristofer, Axume, John, Clark, Jarrod, Dyachenko, Olga V., Caudill, Marie, Buryanov, Yaroslav, Smith, Steven S.

“…Several reports suggest that CmCWGG methylation tends not to co-exist with mCG methylation in human cells. We have asked whether or not methylation at CCWGG…”
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