Search Results - "Krett, Nancy L."

Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer by Jana, Arundhati, Das, Archita, Krett, Nancy L, Guzman, Grace, Thomas, Alexandra, Mancinelli, Georgina, Bauer, Jessica, Ushio-Fukai, Masuko, Fukai, Tohru, Jung, Barbara

“…Colorectal cancer remains a deadly cancer due to metastatic disease. To understand the molecular mechanisms of metastasis in colon cancer, we investigated…”
Get full text

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy by McBrayer, Samuel K., Cheng, Javelin C., Singhal, Seema, Krett, Nancy L., Rosen, Steven T., Shanmugam, Mala

“…Multiple myeloma is one of numerous malignancies characterized by increased glucose consumption, a phenomenon with significant prognostic implications in this…”
Get full text

NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway by Jana, Arundhati, Krett, Nancy L, Guzman, Grace, Khalid, Ahmer, Ozden, Ozkan, Staudacher, Jonas J, Bauer, Jessica, Baik, Seung Hyun, Carroll, Timothy, Yazici, Cemal, Jung, Barbara

“…Colorectal cancer (CRC) remains a common and deadly cancer due to metastatic disease. Activin and TGFB (TGFβ) signaling are growth suppressive pathways that…”
Get full text

Mechanisms of Glucocorticoid-mediated Apoptosis in Hematological Malignancies by GREENSTEIN, Stephanie, GHIAS, Kulsoom, KRETT, Nancy L, ROSEN, Steven T

“…Although glucocorticoids (GCs) have been used for their immunosuppressive, anti-inflammatory, and cytotoxic effects for many years, their precise mechanism of…”
Get full text

Coencapsulation of Arsenic- and Platinum-based Drugs for Targeted Cancer Treatment by Chen, Haimei, Pazicni, Samuel, Krett, Nancy L, Ahn, Richard W, Penner-Hahn, James E, Rosen, Steven T, O'Halloran, Thomas V

“…Two in one: A novel strategy for efficiently coencapsulating both arsenic‐ and platinum‐based drugs into 100 nm‐scale liposomes (NBs) relies on the formation…”
Get full text

A collection of bioconductor methods to visualize gene-list annotations by Feng, Gang, Du, Pan, Krett, Nancy L, Tessel, Michael, Rosen, Steven, Kibbe, Warren A, Lin, Simon M

“…Gene-list annotations are critical for researchers to explore the complex relationships between genes and functionalities. Currently, the annotations of a gene…”
Get full text

Targeting Glucose Consumption and Autophagy in Myeloma with the Novel Nucleoside Analogue 8-Aminoadenosine by Shanmugam, Mala, McBrayer, Samuel K., Qian, Jun, Raikoff, Kiril, Avram, Michael J., Singhal, Seema, Gandhi, Varsha, Schumacker, Paul T., Krett, Nancy L., Rosen, Steven T.

“…Multiple myeloma, an incurable plasma cell malignancy, is characterized by altered cellular metabolism and resistance to apoptosis. Recent connections between…”
Get full text

Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms by McBrayer, Samuel K, Yarrington, Michael, Qian, Jun, Feng, Gang, Shanmugam, Mala, Gandhi, Varsha, Krett, Nancy L, Rosen, Steven T

“…The nucleoside analogues 8-amino-adenosine and 8-chloro-adenosine have been investigated in the context of B-lineage lymphoid malignancies by our laboratories…”
Get full text

8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: Role in induction of apoptosis in multiple myeloma by Ghias, Kulsoom, Ma, Chunguang, Gandhi, Varsha, Platanias, Leonidas C, Krett, Nancy L, Rosen, Steven T

“…Multiple myeloma is a slowly proliferating B-cell malignancy that accumulates apoptosis-resistant and replication-quiescent cell populations, posing a…”
Get full text

8-Amino-adenosine is a potential therapeutic agent for multiple myeloma by Krett, Nancy L, Davies, Katharine M, Ayres, Mary, Ma, Chunguang, Nabhan, Chadi, Gandhi, Varsha, Rosen, Steven T

“…Multiple myeloma (MM) is a malignancy of clonal B-cells that accounts for 10% of all hematologic malignancies. We have shown previously that a novel purine…”
Get full text

Steroid receptor and microRNA regulation in cancer by Tessel, Michael A, Krett, Nancy L, Rosen, Steven T

“…PURPOSE OF REVIEWSteroid hormone receptors (SHR) are crucial regulators of disease and the basis for clinical intervention in cancers. Recent evidence confirms…”
Get full text

TGFβ and activin A in the tumor microenvironment in colorectal cancer by Zessner-Spitzenberg, Jasmin, Thomas, Alexandra L, Krett, Nancy L, Jung, Barbara

“…Although overall survival in colorectal cancer (CRC) is increasing steadily due to progress in screening, therapeutic options and precise diagnostic tools…”
Get full text

Identification of p38β as a Therapeutic Target for the Treatment of Sézary Syndrome by Bliss-Moreau, Meghan, Coarfa, Cristian, Gunaratne, Preethi H., Guitart, Joan, Krett, Nancy L., Rosen, Steven T.

“…Cutaneous T-cell lymphomas (CTCLs) represent a group of hematopoietic malignancies that home to the skin and have no known molecular basis for disease…”
Get full text

Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index by Thomas, Alexandra L., Castellanos, Karla, Mancinelli, Georgina, Xia, Yinglin, Bauer, Jessica, Yazici, Cemal, Fantuzzi, Giamila, Hwang, Rosa F., Krett, Nancy L., Papachristou, Georgios I., Whitcomb, David C., Jung, Barbara

“…Acute pancreatitis (AP) is a healthcare challenge with considerable mortality. Treatment is limited to supportive care, highlighting the need to investigate…”
Get full text

8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers by Polotskaia, Alla, Hoffman, Sandy, Krett, Nancy L, Shanmugam, Mala, Rosen, Steven T, Bargonetti, Jill

“…8-Amino-adenosine (8-NH(2)-Ado) is a ribose sugar nucleoside analogue that reduces cellular ATP levels and inhibits mRNA synthesis. Estrogen receptor-negative…”
Get full text

Inhibition of Glycogen Synthase Kinase-3 Increases the Cytotoxicity of Enzastaurin by Rovedo, Mark A., Krett, Nancy L., Rosen, Steven T.

“…Cutaneous T-cell lymphomas (CTCL) represent a spectrum of several distinct non-Hodgkin's lymphomas that are characterized by an invasion of the skin by…”
Get full text

Lipid Encapsulation of Arsenic Trioxide Attenuates Cytotoxicity and Allows for Controlled Anticancer Drug Release by Chen, Haimei, MacDonald, Robert C, Li, Shuyou, Krett, Nancy L, Rosen, Steven T, O'Halloran, Thomas V

“…Arsenic trioxide (ATO, As2O3) is emerging as a front line agent for treatment of acute promyelocytic leukemia with giving a complete remission rate of 83−95%…”
Get full text

The Selective Protein Kinase C β Inhibitor Enzastaurin Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines through the AKT Pathway by Querfeld, Christiane, Rizvi, Mujahid A., Kuzel, Timothy M., Guitart, Joan, Rademaker, Alfred, Sabharwal, Simran S., Krett, Nancy L., Rosen, Steven T.

“…Enzastaurin displays pro-apoptotic properties against a spectrum of malignancies and is currently being investigated in clinical trials. We have investigated…”
Get full text

Inhibition of ATP synthase by chlorinated adenosine analogue by Chen, Lisa S., Nowak, Billie J., Ayres, Mary L., Krett, Nancy L., Rosen, Steven T., Zhang, Shuxing, Gandhi, Varsha

“…Phosphorylated metabolites of 8-chloroadenosine (8-Cl-Ado). Phosphorylation of 8-Cl-ADP by ATP synthase to form 8-Cl-ATP and subsequent inhibition of ATP…”
Get full text

Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines by Rizvi, Mujahid A., Ghias, Kulsoom, Davies, Katharine M., Ma, Chunguang, Weinberg, Frank, Munshi, Hidayatullah G., Krett, Nancy L., Rosen, Steven T.

“…Enzastaurin (LY317615), an acyclic bisindolylmaleimide, is an oral inhibitor of the protein kinase Cβ isozyme. The objective of this study was to assess the…”
Get full text