Search Results - "Kretschmer, Simon"

Advances in the Computational Design of Small-Molecule-Controlled Protein-Based Circuits for Synthetic Biology by Kretschmer, Simon, Kortemme, Tanja

“…Synthetic biology approaches living systems with an engineering perspective and promises to deliver solutions to global challenges in healthcare and…”
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Pattern formation on membranes and its role in bacterial cell division by Kretschmer, Simon, Schwille, Petra

“…Bacterial cell division is arguably one of the most central processes in biology. Despite the identification of many important molecular players, surprisingly…”
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Design, Synthesis, and Structure–Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5‑Lipoxygenase by Hiesinger, Kerstin, Kramer, Jan S, Beyer, Sandra, Eckes, Timon, Brunst, Steffen, Flauaus, Cathrin, Wittmann, Sandra K, Weizel, Lilia, Kaiser, Astrid, Kretschmer, Simon B. M, George, Sven, Angioni, Carlo, Heering, Jan, Geisslinger, Gerd, Schubert-Zsilavecz, Manfred, Schmidtko, Achim, Pogoryelov, Denys, Pfeilschifter, Josef, Hofmann, Bettina, Steinhilber, Dieter, Schwalm, Stephanie, Proschak, Ewgenij

“…Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. Merging of 5-lipoxygenase (5-LOX) and soluble…”
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MinE conformational switching confers robustness on self-organized Min protein patterns by Denk, Jonas, Kretschmer, Simon, Halatek, Jacob, Hartl, Caroline, Schwille, Petra, Frey, Erwin

“…Protein patterning is vital for many fundamental cellular processes. This raises two intriguing questions: Can such intrinsically complex processes be reduced…”
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Large-scale modulation of reconstituted Min protein patterns and gradients by defined mutations in MinE's membrane targeting sequence by Kretschmer, Simon, Zieske, Katja, Schwille, Petra

“…The E. coli MinDE oscillator is a paradigm for protein self-organization and gradient formation. Previously, we reconstituted Min protein wave patterns on flat…”
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Synthetic cell division via membrane-transforming molecular assemblies by Kretschmer, Simon, Ganzinger, Kristina A, Franquelim, Henri G, Schwille, Petra

“…Reproduction, i.e. the ability to produce new individuals from a parent organism, is a hallmark of living matter. Even the simplest forms of reproduction…”
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Non‐Equilibrium Large‐Scale Membrane Transformations Driven by MinDE Biochemical Reaction Cycles by Fu, Meifang, Franquelim, Henri G., Kretschmer, Simon, Schwille, Petra

“…The MinDE proteins from E. coli have received great attention as a paradigmatic biological pattern‐forming system. Recently, it has surfaced that these…”
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Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae by Trussart, Marie, Yus, Eva, Martinez, Sira, Baù, Davide, Tahara, Yuhei O., Pengo, Thomas, Widjaja, Michael, Kretschmer, Simon, Swoger, Jim, Djordjevic, Steven, Turnbull, Lynne, Whitchurch, Cynthia, Miyata, Makoto, Marti-Renom, Marc A., Lluch-Senar, Maria, Serrano, Luís

“…DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the…”
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Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism by Rödl, Carmen B., Vogt, Dominik, Kretschmer, Simon B.M., Ihlefeld, Katja, Barzen, Sebastian, Brüggerhoff, Astrid, Achenbach, Janosch, Proschak, Ewgenij, Steinhilber, Dieter, Stark, Holger, Hofmann, Bettina

“…Eicosanoids like leukotrienes and prostaglandins play a considerable role in inflammation. Produced within the arachidonic acid (AA) cascade, these lipid…”
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Optical Control of a Biological Reaction–Diffusion System by Glock, Philipp, Broichhagen, Johannes, Kretschmer, Simon, Blumhardt, Philipp, Mücksch, Jonas, Trauner, Dirk, Schwille, Petra

“…Patterns formed by reaction and diffusion are the foundation for many phenomena in biology. However, the experimental study of reaction–diffusion (R–D) systems…”
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Increasing MinD's Membrane Affinity Yields Standing Wave Oscillations and Functional Gradients on Flat Membranes by Kretschmer, Simon, Heermann, Tamara, Tassinari, Andrea, Glock, Philipp, Schwille, Petra

“…The formation of large-scale patterns through molecular self-organization is a basic principle of life. Accordingly, the engineering of protein patterns and…”
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Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418 by Maucher, Isabelle V., Rühl, Michael, Kretschmer, Simon B.M., Hofmann, Bettina, Kühn, Benjamin, Fettel, Jasmin, Vogel, Anja, Flügel, Karsten T., Manolikakes, Georg, Hellmuth, Nadine, Häfner, Ann-Kathrin, Golghalyani, Vahid, Ball, Ann-Katrin, Piesche, Matthias, Matrone, Carmela, Geisslinger, Gerd, Parnham, Michael J., Karas, Michael, Steinhilber, Dieter, Roos, Jessica, Maier, Thorsten J.

“…[Display omitted] Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting…”
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Stationary Patterns in a Two-Protein Reaction-Diffusion System by Glock, Philipp, Ramm, Beatrice, Heermann, Tamara, Kretschmer, Simon, Schweizer, Jakob, Mücksch, Jonas, Alagöz, Gökberk, Schwille, Petra

“…Patterns formed by reaction-diffusion mechanisms are crucial for the development or sustenance of most organisms in nature. Patterns include dynamic waves, but…”
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Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles by Kretschmer, Simon B.M., Woltersdorf, Stefano, Vogt, Dominik, Lillich, Felix F., Rühl, Michael, Karas, Michael, Maucher, Isabelle V., Roos, Jessica, Häfner, Ann-Kathrin, Kaiser, Astrid, Wurglics, Mario, Schubert-Zsilavecz, Manfred, Angioni, Carlo, Geisslinger, Gerd, Stark, Holger, Steinhilber, Dieter, Hofmann, Bettina

“…[Display omitted] 5-Lipoxygenase (5-LO, EC1.13.11.34) has been implicated in the pathogenesis of inflammatory and immune diseases. Recently, aminothiazole…”
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Development of novel aminothiazole-comprising 5-LO inhibitors by M Kretschmer, Simon B, Woltersdorf, Stefano, Rödl, Carmen B, Vogt, Dominik, Häfner, Ann-Kathrin, Steinhilber, Dieter, Stark, Holger, Hofmann, Bettina

“…Leukotrienes are pivotal lipid mediators in various immune and inflammatory reactions. Herein, 5-LO is a validated target. 2-Aminothiazoles, as a privileged…”
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Toward Spatially Regulated Division of Protocells: Insights into the E. coli Min System from in Vitro Studies by Kretschmer, Simon, Schwille, Petra

“…For reconstruction of controlled cell division in a minimal cell model, or protocell, a positioning mechanism that spatially regulates division is…”
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Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase by Meirer, Karin, Glatzel, Daniel, Kretschmer, Simon, Wittmann, Sandra K, Hartmann, Markus, Blöcher, René, Angioni, Carlo, Geisslinger, Gerd, Steinhilber, Dieter, Hofmann, Bettina, Fürst, Robert, Proschak, Ewgenij

“…The arachidonic acid cascade is a key player in inflammation, and numerous well-established drugs interfere with this pathway. Previous studies have suggested…”
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Exploring the Chemical Space of Multitarget Ligands Using Aligned Self-Organizing Maps by Achenbach, Janosch, Klingler, Franca-Maria, Blöcher, René, Moser, Daniel, Häfner, Ann-Kathrin, Rödl, Carmen B, Kretschmer, Simon, Krüger, Björn, Löhr, Frank, Stark, Holger, Hofmann, Bettina, Steinhilber, Dieter, Proschak, Ewgenij

“…Design of multitarget drugs and polypharmacological compounds has become popular during the past decade. However, the main approach to design such compounds is…”
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Reverse and forward engineering of protein pattern formation by Kretschmer, Simon, Harrington, Leon, Schwille, Petra

“…Living systems employ protein pattern formation to regulate important life processes in space and time. Although pattern-forming protein networks have been…”
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Reverse and forward engineering of protein pattern formation by Kretschmer, Simon, Harrington, Leon, Schwille, Petra

“…Living systems employ protein pattern formation to regulate important life processes in space and time. Although pattern-forming protein networks have been…”
Get full text