Search Results - "Kreppel, F"

Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity by Krutzke, L., Prill, J.M., Engler, T., Schmidt, C.Q., Xu, Z., Byrnes, A.P., Simmet, T., Kreppel, F.

“…The biodistribution of adenovirus type 5 (Ad5) vector particles is heavily influenced by interaction of the particles with plasma proteins, including…”
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An ex vivo loop system models the toxicity and efficacy of PEGylated and unmodified adenovirus serotype 5 in whole human blood by Danielsson, A, Elgue, G, Nilsson, B M, Nilsson, B, Lambris, J D, Tötterman, T H, Kochanek, S, Kreppel, F, Essand, M

“…Polyethylene glycol coating (PEGylation) of adenovirus serotype 5 (Ad5) has been shown to effectively reduce immunogenicity and increase circulation time of…”
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399 HEPATIC ACTIVATION OF IKK/NF-KB SIGNALING INDUCES LIVER FIBROSIS VIA MACROPHAGE-MEDIATED CHRONIC INFLAMMATION by Sunami, Y, Leitháuser, F, Gul, S, Fiedler, K, Güldiken, N, Espenlaub, S, Holzmann, K.-H, Sindrilaru, A, Lüdde, T, Baumann, B, Wissel, S, Kreppel, F, Schneider, M, Scharffetter-Kochanek, K, Kochanek, S, Strnad, P, Wirth, T

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The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo by Kügler, S, Straten, G, Kreppel, F, Isenmann, S, Liston, P, Bähr, M

“…The inhibition of neuronal apoptosis in acute traumatic and ischemic injuries as well as in long term neurodegenerative disorders like spinal muscular atrophy…”
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Interleukin-12 inhibits liver-specific drug-inducible systems in vivo by Reboredo, M, Zabala, M, Mauleon, I, De Las Rivas, J, Kreppel, F, Kochanek, S, Prieto, J, Hernandez-Alcoceba, R, Kramer, M G

“…Drug-inducible systems allow modulation of the duration and intensity of cytokine expression in liver immuno-based gene therapy protocols. However, the…”
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Foamy virus-adenovirus hybrid vectors by PICARD-MAUREAU, M, KREPPEL, F, LINDEMANN, D, JURETZEK, T, HERCHENRÖDER, O, RETHWILM, A, KOCHANEK, S, HEINKELEIN, M

“…To confer adenovirus vectors (AdV), the feature of integration into the host cell genome hybrid vectors were characterized in vitro, which express vectors…”
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SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation by Asher, Gad, Gatfield, David, Stratmann, Markus, Reinke, Hans, Dibner, Charna, Kreppel, Florian, Mostoslavsky, Raul, Alt, Frederick W., Schibler, Ueli

“…The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus of the brain that synchronizes countless subsidiary…”
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Intracerebral transplantation and successful integration of astrocytes following genetic modification with a high-capacity adenoviral vector by Arnhold, S, Kreppel, F, Kandirali, S, Lenartz, D, Klinz, F J, Sturm, V, Kochanek, S, Andressen, C, Addicks, K

“…To investigate the ability of genetically modified astrocytes to integrate into adult rat brain, two spontaneously immortalized cell lines and the allogenic…”
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Combined Genetic and Chemical Capsid Modifications Enable Flexible and Efficient De- and Retargeting of Adenovirus Vectors by Kreppel, Florian, Gackowski, Judith, Schmidt, Erika, Kochanek, Stefan

“…Numerous attempts to target viral gene therapy vectors to specific cells have met with limited success. Here we describe a novel virus vector-targeting…”
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Long-Term Transgene Expression in Proliferating Cells Mediated by Episomally Maintained High-Capacity Adenovirus Vectors by KREPPEL, Florian, KOCHANEK, Stefan

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocvte clocks by Saini, C, Liani, A, Curie, T, Gos, P, Kreppel, F, Emmenegger, Y, Bonacina, L, Wolf, J-P, Poget, Y-A, Franken, P, Schibler, U

“…The mammalian circadian timing system consists of a master pacemaker in the suprachiasmatic nucleus (SCN) in the hypothalamus, which is thought to set the…”
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Capsomer-specific fluorescent labeling of adenoviral vector particles allows for detailed analysis of intracellular particle trafficking and the performance of bioresponsive bonds for vector capsid modifications by Espenlaub, Sigrid, Corjon, Stéphanie, Engler, Tatjana, Fella, Carolin, Ogris, Manfred, Wagner, Ernst, Kochanek, Stefan, Kreppel, Florian

“…Adenoviral (Ad) vectors are widely used for gene therapy approaches. Because of the high abundance of the natural adenoviral receptors…”
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Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways by Dinser, R, Zaucke, F, Kreppel, F, Hultenby, K, Kochanek, S, Paulsson, M, Maurer, P

“…Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into…”
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A DNA-based method to assay total and infectious particle contents and helper virus contamination in high-capacity adenoviral vector preparations by Kreppel, Florian, Biermann, Volker, Kochanek, Stefan, Schiedner, Gudrun

“…High-capacity adenoviral (HC-Ad) vectors are devoid of all viral genes. Therefore, these vectors feature reduced toxicity, immunogenicity, and increased…”
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Autologous Transplantation of Genetically Modified Iris Pigment Epithelial Cells: A Promising Concept for the Treatment of Age-Related Macular Degeneration and Other Disorders of the Eye by Semkova, Irina, Kreppel, Florian, Welsandt, Gerhard, Luther, Thomas, Kozlowski, Jolanta, Janicki, Hanna, Kochanek, Stefan, Schraermeyer, Ulrich

“…Age-related macular degeneration (ARMD) is the leading cause for visual impairment and blindness in the elder population. Laser photocoagulation, photodynamic…”
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Long-Term Transgene Expression in the RPE after Gene Transfer with a High-Capacity Adenoviral Vector by Kreppel, Florian, Luther, Thomas T, Semkova, Irina, Schraermeyer, Ulrich, Kochanek, Stefan

“…To analyze duration of gene expression in the retinal pigment epithelium (RPE) in immunocompetent animals after gene transfer with a high-capacity adenoviral…”
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Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes by Dinser, R, Kreppel, F, Zaucke, F, Blank, C, Paulsson, M, Kochanek, S, Maurer, P

“…Different gene transfer approaches to achieve long-term transgene expression in cultured primary bovine chondrocytes were compared using enhanced green…”
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Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways by Dinser, Robert, Zaucke, Frank, Kreppel, Florian, Hultenby, Kjell, Kochanek, Stefan, Paulsson, Mats, Maurer, Patrik

“…Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into…”
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Local High-Capacity Adenovirus-Mediated mCTLA4Ig and mCD40Ig Expression Prolongs Recombinant Gene Expression in Skeletal Muscle by Jiang, Zhi-Long, Reay, Daniel, Kreppel, Florian, Gambotto, Andrea, Feingold, Eleanor, Kochanek, Stefan, McCarthy, Susan A., Clemens, Paula R.

“…Multiple forms of muscular dystrophy are due to the absence of cytoskeletal muscle proteins that normally protect the integrity of muscle cells. The lack of…”
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Peter Baumgart (Hrsg.): Bildungspolitik in Preussen zur Zeit des Kaiserreichs (Book Review) by Kreppel, F

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