Search Results - "Krens, Lisanne L"

Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review by Baas, Jara M., Krens, Lisanne L., Guchelaar, Henk‐Jan, Morreau, Hans, Gelderblom, Hans

“…Background. Currently, only Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutational status is used as a decisional marker for epidermal growth factor…”
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Statin use is not associated with improved progression free survival in cetuximab treated KRAS mutant metastatic colorectal cancer patients: results from the CAIRO2 study by Krens, Lisanne L, Simkens, Lieke H J, Baas, Jara M, Koomen, Els R, Gelderblom, Hans, Punt, Cornelis J A, Guchelaar, Henk-Jan

“…Statins may inhibit the expression of the mutant KRAS phenotype by preventing the prenylation and thus the activation of the KRAS protein. This study was aimed…”
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Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients by Baas, Jara M, Krens, Lisanne L, Bos, Monique M, Portielje, Johanneke E.A, Batman, Erdogan, van Wezel, Tom, Morreau, Hans, Guchelaar, Henk-Jan, Gelderblom, Hans

“…Panitumumab has proven efficacy in patients with metastatic or locally advanced colorectal cancer patients, provided that they have no activating KRAS mutation…”
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Therapeutic modulation of k-ras signaling in colorectal cancer by Krens, Lisanne L., Baas, Jara M., Gelderblom, Hans, Guchelaar, Henk-Jan

“…KRAS has an important role in colorectal carcinogenesis and mutant KRAS leads to a permanently activated k-ras protein. To exert its biological activity, k-ras…”
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Assessment of Contraceptive Counseling and Contraceptive Use in Women After Bariatric Surgery by Damhof, Michiel A., Pierik, Esther, Krens, Lisanne L., Vermeer, Marloes, van Det, Marc J., van Roon, Eric N.

“…Background Reproductive-aged women are, according to American and European guidelines, recommended to avoid pregnancy for 12–24 months after bariatric surgery…”
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