Search Results - "Krenn, Peter"

Targeting cancer hallmark vulnerabilities in hematologic malignancies by interfering with Hedgehog/GLI signaling by Krenn, Peter W, Aberger, Fritz

“…Understanding the genetic alterations, disrupted signaling pathways, and hijacked mechanisms in oncogene-transformed hematologic cells is critical for the…”
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The cytokine network in acute myeloid leukemia by Luciano, Michela, Krenn, Peter W, Horejs-Hoeck, Jutta

“…Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone marrow, characterized by clonal expansion of myeloid stem and…”
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Neutrophils direct preexisting matrix to initiate repair in damaged tissues by Fischer, Adrian, Wannemacher, Juliane, Christ, Simon, Koopmans, Tim, Kadri, Safwen, Zhao, Jiakuan, Gouda, Mahesh, Ye, Haifeng, Mück-Häusl, Martin, Krenn, Peter W., Machens, Hans-Günther, Fässler, Reinhard, Neumann, Philipp-Alexander, Hauck, Stefanie M., Rinkevich, Yuval

“…Internal organs heal injuries with new connective tissue, but the cellular and molecular events of this process remain obscure. By tagging extracellular matrix…”
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Moment-based inference predicts bimodality in transient gene expression by Zechner, Christoph, Ruess, Jakob, Krenn, Peter, Pelet, Serge, Peter, Matthias, Lygeros, John, Koeppl, Heinz

“…Recent computational studies indicate that the molecular noise of a cellular process may be a rich source of information about process dynamics and parameters…”
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Hedgehog/GLI signaling in hematopoietic development and acute myeloid leukemia-From bench to bedside by Tesanovic, Suzana, Krenn, Peter W, Aberger, Fritz

“…While the underlying genetic alterations and biology of acute myeloid leukemia (AML), an aggressive hematologic malignancy characterized by clonal expansion of…”
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ICAP‐1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice by Sevilla‐Movilla, Silvia, Fuentes, Patricia, Rodríguez‐García, Yaiza, Arellano‐Sánchez, Nohemi, Krenn, Peter W., Val, Soledad Isern, Montero‐Herradón, Sara, García‐Ceca, Javier, Burdiel‐Herencia, Valeria, Gardeta, Sofía R., Aguilera‐Montilla, Noemí, Barrio‐Alonso, Celia, Crainiciuc, Georgiana, Bouvard, Daniel, García‐Pardo, Angeles, Zapata, Agustin G., Hidalgo, Andrés, Fässler, Reinhard, Carrasco, Yolanda R., Toribio, Maria L., Teixidó, Joaquin

“…ICAP‐1 regulates β1‐integrin activation and cell adhesion. Here, we used ICAP‐1‐null mice to study ICAP‐1 potential involvement during immune cell development…”
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Nonadiabatic dynamics of two strongly coupled nanomechanical resonator modes by Faust, Thomas, Rieger, Johannes, Seitner, Maximilian J, Krenn, Peter, Kotthaus, Jörg P, Weig, Eva M

“…The Landau-Zener transition is a fundamental concept for dynamical quantum systems and has been studied in numerous fields of physics. Here, we present a…”
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Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells by Hofbauer, Sebastian W., Krenn, Peter W., Ganghammer, Sylvia, Asslaber, Daniela, Pichler, Ulrike, Oberascher, Karin, Henschler, Reinhard, Wallner, Michael, Kerschbaum, Hubert, Greil, Richard, Hartmann, Tanja N.

“…Signals from the tumor microenvironment promote the migration, survival, and proliferation of chronic lymphocytic leukemia (CLL) cells. Rho GTPases control…”
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Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells from protective bone marrow niches by Krenn, Peter William, Koschmieder, Steffen, Fässler, Reinhard

“…Kindlin-3 (K3)–mediated integrin adhesion controls homing and bone marrow (BM) retention of normal hematopoietic cells. However, the role of K3 in leukemic…”
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Kindlin‐3 maintains marginal zone B cells but confines follicular B cell activation and differentiation by Härzschel, Andrea, Li, Lixia, Krenn, Peter W., Szenes‐Nagy, Eva, Andrieux, Geoffroy, Bayer, Elisabeth, Pfeifer, Dietmar, Polcik, Laura, Denk, Ursula, Höpner, Jan P., Karabatak, Elif, Danner, Danielle‐Justine, Tangermann, Simone, Kenner, Lukas, Jumaa, Hassan, Greil, Richard, Börries, Melanie, Ruppert, Raphael, Maity, Palash C., Hartmann, Tanja Nicole

“…Integrin‐mediated interactions between hematopoietic cells and their microenvironment are important for the development and function of immune cells. Here, the…”
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The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1 by Margraf, Andreas, Germena, Giulia, Drexler, Hannes C.A., Rossaint, Jan, Ludwig, Nadine, Prystaj, Barbara, Mersmann, Sina, Thomas, Katharina, Block, Helena, Gottschlich, Wiebke, Liu, Chang, Krenn, Peter W., Haller, Hermann, Heitplatz, Barbara, Meyer zu Brickwedde, Marika, Moser, Markus, Vestweber, Dietmar, Zarbock, Alexander

“…Neutrophil adhesion and extravasation into tissue at sites of injury or infection depend on binding of the integrin lymphocyte function–associated antigen 1…”
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Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis by Luciano, Michela, Sieberer, Helene, Krenn, Peter W, Dang, Hieu-Hoa, Vetter, Julia, Neuper, Theresa, Amend, Diana, Blöchl, Constantin, Weichenberger, Christian X, Eglseer, Anna, Unger, Michael S, Andosch, Ancuela, Steiner, Philip, Neureiter, Daniel, Bauer, Renate, Hummer, Laura, Tesanovic, Suzana, Binder, Stephanie, Elmer, Dominik P, Strandt, Helen, Schaller, Susanne, Strunk, Dirk, Pleyer, Lisa, Greil, Richard, Winkler, Stephan, Hartmann, Tanja N, Schmidt-Arras, Dirk, Huber, Christian G, Aberger, Fritz, Horejs-Hoeck, Jutta

“…Acute myeloid leukemia (AML) is characterized by the abnormal proliferation of myeloid precursor cells and presents significant challenges in treatment due to…”
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Integrins, anchors and signal transducers of hematopoietic stem cells during development and in adulthood by Krenn, Peter W, Montanez, Eloi, Costell, Mercedes, Fässler, Reinhard

“…Hematopoietic stem cells (HSCs), the apex of the hierarchically organized blood cell production system, are generated in the yolk sac, aorta-gonad-mesonephros…”
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ADP-heptose attenuates Helicobacter pylori -induced dendritic cell activation by Neuper, Theresa, Frauenlob, Tobias, Dang, Hieu-Hoa, Krenn, Peter W, Posselt, Gernot, Regl, Christof, Fortelny, Nikolaus, Schäpertöns, Veronika, Unger, Michael S, Üblagger, Gunda, Neureiter, Daniel, Mühlbacher, Iris, Weitzendorfer, Michael, Singhartinger, Franz, Emmanuel, Klaus, Huber, Christian G, Wessler, Silja, Aberger, Fritz, Horejs-Hoeck, Jutta

“…Sophisticated immune evasion strategies enable to colonize the gastric mucosa of approximately half of the world's population. Persistent infection and the…”
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CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation‐dependent and ‐independent mechanisms by Hutterer, Evelyn, Asslaber, Daniela, Caldana, Chiara, Krenn, Peter W., Zucchetto, Antonella, Gattei, Valter, Greil, Richard, Hartmann, Tanja N.

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Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors by Ganghammer, Sylvia, Gutjahr, Julia, Hutterer, Evelyn, Krenn, Peter W, Pucher, Susanne, Zelle-Rieser, Claudia, Jöhrer, Karin, Wijtmans, Maikel, Leurs, Rob, Smit, Martine J, Gattei, Valter, Greil, Richard, Hartmann, Tanja N

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Taxation and agency conflicts between firm owners and managers: a review by Bauer, Thomas, Kourouxous, Thomas, Krenn, Peter

“…When analyzing the influence of taxation on agency conflicts between firm owners and managers, one can draw on theoretical principal-agent literature from…”
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The Class IIA Histone Deacetylase (HDAC) Inhibitor TMP269 Downregulates Ribosomal Proteins and Has Anti-Proliferative and Pro-Apoptotic Effects on AML Cells by Urwanisch, Laura, Unger, Michael Stefan, Sieberer, Helene, Dang, Hieu-Hoa, Neuper, Theresa, Regl, Christof, Vetter, Julia, Schaller, Susanne, Winkler, Stephan M, Kerschbamer, Emanuela, Weichenberger, Christian X, Krenn, Peter W, Luciano, Michela, Pleyer, Lisa, Greil, Richard, Huber, Christian G, Aberger, Fritz, Horejs-Hoeck, Jutta

“…Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by altered myeloid progenitor cell proliferation and differentiation. As in many other…”
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BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia by Haerzschel, Andrea, Catusse, Julie, Hutterer, Evelyn, Paunovic, Manuela, Zirlik, Katja, Eibel, Hermann, Krenn, Peter W., Hartmann, Tanja N., Burger, Meike

“…Dysregulation of B cell receptor (BCR) signalling is a hallmark of chronic lymphocytic leukaemia (CLL) pathology, and targeting BCR pathway kinases has brought…”
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The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells by Hofbauer, Sebastian W., Krenn, Peter W., Piñόn Hofbauer, Josefina, Pucher, Susanne, Asslaber, Daniela, Egle, Alexander, Hartmann, Tanja N., Greil, Richard

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