Search Results - "Kremers, M."

Implementation of a care-pathway at the emergency department for older people presenting with nonspecific complaints; a protocol for a multicenter parallel cohort study by van der Velde, M. G. A. M, Jansen, M. A. C, de Jongh, M. A. C, Kremers, M. N. T, Haak, H. R

“…Background Older adults frequently attend the Emergency Department (ED) with poorly defined symptoms, often called nonspecific complaints (NSC). NSC such as…”
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Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease by Kremers, B. M. M., Posma, J. N., Heitmeier, S., Glunz, J., ten Cate, H., Pallares Robles, A., Daemen, J. H. C., ten Cate-Hoek, A. J., Mees, B. M. E., Spronk, H. M. H.

“…Peripheral artery disease (PAD) patients have an increased cardiovascular risk despite pharmacological treatment strategies. Biomarker research improving risk…”
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Towards standardization of thrombin generation assays: Inventory of thrombin generation methods based on results of an International Society of Thrombosis and Haemostasis Scientific Standardization Committee survey by de Laat‐Kremers, Romy M. W., Ninivaggi, Marisa, Devreese, Katrien M. J., de Laat, Bas

“…Background Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than the routinely used clotting time‐based…”
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Risk factors for hospitalisation in community-dwelling pre-frail and frail older people: results of a longitudinal study by van der Velde, M G A M, Op Het Veld, L P M, van Rossum, E, Jansen, M A C, Haak, H R, Kremers, M N T

“…Older adults account for a large proportion of hospital admissions. In this study we aim to bridge a gap between medical and psychosocial factors in predicting…”
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Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection by Huang, Shengshi, van der Heijden, Wouter, Reuling, Isaie J, Wan, Jun, Yan, Qiuting, de Laat - Kremers, Romy M. W, Van der Ven, Andre J, de Groot, Philip G, McCall, Matthew, Sauerwein, Robert W, Bousema, Teun, Roest, Mark, Ninivaggi, Marisa, de Mast, Quirijn, de Laat, Bas

“…Decreased platelet count is an early phenomenon in asexual Plasmodium falciparum parasitemia, but its association with acute or long-term functional changes in…”
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Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis by Kremers, Romy M W, Kleinegris, Marie-Claire, Ninivaggi, Marisa, de Laat, Bas, Ten Cate, Hugo, Koek, Ger H, Wagenvoord, Rob J, Hemker, H Coenraad

“…Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or…”
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Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study by Kremers, B M M, Daemen, J H C, Ten Cate, H, Spronk, H M H, Mees, B M E, Ten Cate-Hoek, A J

“…Patients with peripheral artery disease (PAD) are treated with preventive strategies to improve the cardiovascular risk. The incidence of cardiovascular events…”
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Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation by de Laat-Kremers, Romy M. W., Ninivaggi, Marisa, van Moort, Iris, de Maat, Moniek, de Laat, Bas

“…Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make…”
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Deciphering the coagulation profile through the dynamics of thrombin activity by de Laat-Kremers, Romy M. W., Yan, Qiuting, Ninivaggi, Marisa, de Maat, Moniek, de Laat, Bas

“…Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic…”
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The psychosocial adaptability of independently living older adults to COVID‐19 related social isolation in the Netherlands: A qualitative study by Kremers, Evi M., Janssen, Jeroen H. M., Nieuwboer, Minke S., Olde Rikkert, Marcel G. M., Peeters, G. M. E. E. (Geeske)

“…Since coronavirus disease 2019 (COVID‐19) entered the Netherlands, the older adults (aged 70 or above) were recommended to isolate themselves, resulting in…”
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Organisation of internal medicine in acute care in the Netherlands: a detailed overview by Kremers, M N T, Wachelder, J J H, Nanayakkara, P W B, Haak On Behalf Of The Orca Onderzoeks Consortium Acute Geneeskunde Acute Medicine Research Consortium, H R

“…BACKGROUNDOrganisation of the emergency department (ED) is gaining attention due to an increased demand on emergency services, leading to crowding and…”
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ST Genesia reference values of 117 healthy donors measured with STG‐BleedScreen, STG‐DrugScreen and STG‐ThromboScreen reagents by Ninivaggi, Marisa, de Laat‐Kremers, Romy M.W., Carlo, Audrey, de Laat, Bas

“…The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout…”
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The effect of fibrin(ogen) on thrombin generation and decay by Kremers, R M W, Wagenvoord, R J, Hemker, H C

“…Defibrination causes a ~30% decrease of thrombin generation (TG) which can be restored by adding native fibrinogen in its original concentration (3 mg/ml). The…”
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Haemostatic differences between SARS-CoV-2 PCR-positive and negative patients at the time of hospital admission by de Laat, B, Traets, M J M, De Laat-Kremers, R W M, Verweij, S P, Ninivaggi, M, Jong, E, Huskens, D, Blok, B A, Remme, G C P, Miszta, A, Nijhuis, R H T, Herder, G J M, Fijnheer, R, Roest, M, Fiolet, A T L, Remijn, J A

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with thrombosis. We conducted a…”
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Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups by Kremers, Romy M W, Mohamed, Abdulrahman B O, Pelkmans, Leonie, Hindawi, Salwa, Hemker, H Coenraad, de Laat, H Bas, Huskens, Dana, Al Dieri, Raed

“…Individuals with blood group O have a higher bleeding risk than non-O blood groups. This could be explained by the lower levels of FVIII and von Willebrand…”
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Correlations between peripheral blood Coxiella burnetii DNA load, interleukin-6 levels, and C-reactive protein levels in patients with acute Q fever by Kremers, M N T, Janssen, R, Wielders, C C H, Kampschreur, L M, Schneeberger, P M, Netten, P M, de Klerk, A, Hodemaekers, H M, Hermans, M H A, Notermans, D W, Wever, P C

“…From 2007 to 2010, the Netherlands experienced the largest reported Q fever outbreak, with >4,000 notified cases. We showed previously that C-reactive protein…”
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Searching for a Common Thrombo-Inflammatory Basis in Patients With Deep Vein Thrombosis or Peripheral Artery Disease by Kremers, Bram M M, Birocchi, Simone, van Oerle, Rene, Zeerleder, Sacha, Spronk, Henri M H, Mees, Barend M E, Luken, Brenda M, Ten Cate, Hugo, Ten Cate-Hoek, Arina J

“…Inflammation and hypercoagulability play a pivotal role in venous thromboembolism and atherothrombosis. Since venous thrombosis increases the risk of…”
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Reference values for thrombin dynamics in platelet rich plasma by Yan, Qiuting, Ninivaggi, Marisa, de Laat, Bas, de Laat-Kremers, Romy M. W.

“…Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be…”
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Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin by Kremers, Romy M.W., Zuily, Stéphane, Kelchtermans, Hilde, Peters, Tessa C., Bloemen, Saartje, Regnault, Véronique, Hemker, H. Coenraad, de Groot, Philip G., Wahl, Denis, de Laat, Bas

“…Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia…”
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Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? by Gonzalez, A, Maradit Kremers, H, Crowson, C S, Ballman, K V, Roger, V L, Jacobsen, S J, O'Fallon, W M, Gabriel, S E

“…To compare the frequency of traditional cardiovascular (CV) risk factors in rheumatoid arthritis (RA) compared to non-RA subjects, and examine their impact on…”
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