Search Results - "Krejsa, Cecile M"

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress by Krejsa, Cecile M., Franklin, Christopher C., White, Collin C., Ledbetter, Jeffrey A., Schieven, Gary L., Kavanagh, Terrance J.

“…Glutamate cysteine ligase (GCL) catalyzes the rate-limiting step in the formation of the cellular antioxidant glutathione (GSH). The GCL holoenzyme consists of…”
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Fluorescence-based microtiter plate assay for glutamate–cysteine ligase activity by White, Collin C, Viernes, Hannah, Krejsa, Cecile M, Botta, Dianne, Kavanagh, Terrance J

“…Glutamate–cysteine ligase (GCL; also known as γ-glutamylcysteine synthetase) is the rate-limiting enzyme in glutathione (GSH) synthesis. Traditional assays for…”
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Interleukin-21 enhances rituximab activity in a cynomolgus monkey model of B cell depletion and in mouse B cell lymphoma models by Krejsa, Cecile M, Holly, Rick D, Heipel, Mark, Bannink, Ken M, Johnson, Rebecca, Roque, Richard, Heffernan, Jane, Hill, Julie, Chin, Lay, Wagener, Felecia, Shiota, Faith, Henderson, Katherine, Sivakumar, Pallavur V, Ren, Hong-Ping, Barahmand-Pour, Fariba, Foster, Don, Clegg, Chris, Kindsvogel, Wayne, Ponce, Rafael, Hughes, Steven D, Waggie, Kim

“…Rituximab, a monoclonal antibody targeting CD20 on B cells, is currently used to treat many subtypes of B cell lymphomas. However, treatment is not curative…”
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Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib by Qin, Jim S., Johnstone, Timothy G., Baturevych, Alex, Hause, Ronald J., Ragan, Seamus P., Clouser, Christopher R., Jones, Jon C., Ponce, Rafael, Krejsa, Cecile M., Salmon, Ruth A., Ports, Michael O.

“…Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for patients with CD19+ B-cell malignancies. Combination strategies that improve CAR…”
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Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices by Pepin, Xavier J.H., Moir, Andrea J., Mann, James C., Sanderson, Natalie J., Barker, Richard, Meehan, Elizabeth, Plumb, Allan P., Bailey, George R., Murphy, Dean S., Krejsa, Cecile M., Andrew, Marilee A., Ingallinera, Timothy G., Slatter, J. Greg

“…[Display omitted] Acalabrutinib (Calquence®) 100 mg (bid) has received accelerated approval by FDA for the treatment of adult patients with mantle cell…”
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Caspase-3-Dependent Cleavage of the Glutamate- l-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death by Franklin, Christopher C., Krejsa, Cecile M., Pierce, Robert H., White, Collin C., Fausto, Nelson, Kavanagh, Terrance J.

“…Apoptotic cell death is usually accompanied by activation of a family of cysteine proteases termed caspases. Caspases mediate the selective proteolysis of…”
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B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin by Dillon, Stacey R, Harder, Brandon, Lewis, Kenneth B, Moore, Margaret D, Liu, Hong, Bukowski, Thomas R, Hamacher, Nels B, Lantry, Megan M, Maurer, Mark, Krejsa, Cecile M, Ellsworth, Jeff L, Pederson, Susan, Elkon, Keith B, Wener, Mark H, Dall'Era, Maria, Gross, Jane A

“…B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell…”
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Induction of glutamate-cysteine ligase (γ-glutamylcysteine synthetase) in the brains of adult female mice subchronically exposed to methylmercury by Thompson, Sally A, White, Collin C, Krejsa, Cecile M, Diaz, Dolores, Woods, James S, Eaton, David L, Kavanagh, Terrance J

“…Methylmercury (MeHg) is widely known for its potent neurotoxic properties. One proposed mechanism of action of MeHg relates to its high affinity for sulfhydryl…”
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Tissue specific changes in the expression of glutamate–cysteine ligase mRNAs in mice exposed to methylmercury by Dı́az, Dolores, Krejsa, Cecile M., White, Collin C., Keener, Cassie L., Farin, Federico M., Kavanagh, Terrance J.

“…Glutamate–cysteine ligase (GLCL), the rate-limiting enzyme in glutathione (GSH) synthesis is composed of two subunits, a catalytic (GLCLc) and a regulatory…”
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Effect of methylmercury on glutamate-cysteine ligase expression in the placenta and yolk sac during mouse development by Dı́az, Dolores, Krejsa, Cecile M., White, Collin C., Charleston, Jay S., Kavanagh, Terrance J.

“…The placenta and the yolk sac play critical roles in fetal development, including protection from oxidative stress through the presence of detoxifying enzymes…”
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An inter-laboratory retrospective analysis of immunotoxicological endpoints in non-human primates: flow cytometry immunophenotyping by Krejsa, Cecile M, Neradilek, Moni Blazej, Polissar, Nayak L, Cox, Nick, Clark, Darcey, Cowan, Laine, Bussiere, Jeanine, Lebrec, Herve

“…Non-human primates may be the only relevant species for pharmacology or toxicology studies of certain biologics, due to lack of activity in other species. Flow…”
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244 Anti-Interleukin (IL)-21 Monoclonal Antibody Reduces Disease Severity and Inflammatory Cytokines in Murine Colitis by Lewis, Katherine E, Bilsborough, Janine, Maurer, Mark F, Bontadelli, Kristen, Waggie, Kim, Krejsa, Cecile M, Dillon, Stacey R

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Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis by Botta, Dianne, Franklin, Christopher C., White, Collin C., Krejsa, Cecile M., Dabrowski, Michael J., Pierce, Robert H., Fausto, Nelson, Kavanagh, Terrance J.

“…Glutathione (GSH) is important in free radical scavenging, maintaining cellular redox status, and regulating cell survival in response to a wide variety of…”
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Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells by Järvinen, K, Pietarinen-Runtti, P, Linnainmaa, K, Raivio, K O, Krejsa, C M, Kavanagh, T, Kinnula, V L

“…The development of drug resistance of tumors is multifactorial and still poorly understood. Some cytotoxic drugs generate free radicals, and, therefore,…”
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Expression of glutamate-cysteine ligase during mouse development by Díaz, Dolores, Krejsa, Cecile M., Kavanagh, Terrance J.

“…The tripeptide glutathione (GSH), which plays a crucial role in protecting cells against oxidative stress, is synthesized in a two‐step process. The…”
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Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development by THOMPSON, Sally A, WHITE, Collin C, KREJSA, Cecile M, EATON, David L, KAVANAGH, Terrance J

“…The antioxidant tripeptide glutathione has been proposed to be important in defense against oxidative stress and heavy metal toxicity. We evaluated alterations…”
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Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury by Dı́az, Dolores, Krejsa, Cecile M., Kavanagh, Terrance J.

“…Methylmercury (MeHg) is a toxicant that targets the kidney among other tissues. MeHg accumulates in the kidney, where it indirectly produces oxidative stress…”
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CYP3A-Mediated Drug Interaction Profile of Bruton Tyrosine Kinase Inhibitor, Acalabrutinib by Izumi, Raquel, Pearson, Paul G., Hamdy, Ahmed, Rodriquez, Sara, Yang, Yolanda Y.L., Ulrich, Roger G., Podoll, Terry, Andrew, Marilee, Krejsa, Cecile M., Ingallinera, Tim, Slatter, J. Greg

“…▪ Background: Acalabrutinib (ACP-196) is a highly selective, potent, covalent inhibitor of Bruton tyrosine kinase (BTK), in development for the treatment of…”
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Predicting ADME properties and side effects: the BioPrint approach by Krejsa, Cecile M, Horvath, Dragos, Rogalski, Sherri L, Penzotti, Julie E, Mao, Boryeu, Barbosa, Frédérique, Migeon, Jacques C

“…Computational methods are increasingly used to streamline and enhance the lead discovery and optimization process. However, accurate prediction of absorption,…”
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Combined Inhibition of mTOR and BTK Signaling Is Required for Optimal Long Term Growth Inhibition in DLBCL Models by Brugger, Wolfram, Hattersley, Maureen, Bussey, Alexandra, Reimer, Corinne, Tron, Adriana E., Staniszewska, Anna, Delpuech, Oona, Carnevalli, Larissa, Krejsa, Cecile M., Mayo, Michele, Neveras, Lynne, San Martin, Maryann, Rideout, Abla, Proia, Theresa, Willis, Brandon, Pease, J. Elizabeth, Hamdy, Ahmed, Cosulich, Sabina C.

“…Introduction: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulator of cell signalling, growth, metabolism…”
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