Search Results - "Krejci, Lumir"

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection by Zadorozhny, Karina, Sannino, Vincenzo, Beláň, Ondrej, Mlčoušková, Jarmila, Špírek, Mário, Costanzo, Vincenzo, Krejčí, Lumír

“…Fanconi anemia (FA) is a genetic disorder characterized by a defect in DNA interstrand crosslink (ICL) repair, chromosomal instability, and a predisposition to…”
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SAMHD1 acts at stalled replication forks to prevent interferon induction by Coquel, Flavie, Silva, Maria-Joao, Técher, Hervé, Zadorozhny, Karina, Sharma, Sushma, Nieminuszczy, Jadwiga, Mettling, Clément, Dardillac, Elodie, Barthe, Antoine, Schmitz, Anne-Lyne, Promonet, Alexy, Cribier, Alexandra, Sarrazin, Amélie, Niedzwiedz, Wojciech, Lopez, Bernard, Costanzo, Vincenzo, Krejci, Lumir, Chabes, Andrei, Benkirane, Monsef, Lin, Yea-Lih, Pasero, Philippe

“…SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections. Mutations in SAMHD1 are implicated in cancer development and in a…”
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Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function by Špírek, Mário, Taylor, Martin R. G., Belan, Ondrej, Boulton, Simon J., Krejci, Lumir

“…The RAD51 recombinase assembles as helical nucleoprotein filaments on single-stranded DNA (ssDNA) and mediates invasion and strand exchange with homologous…”
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Strand invasion by HLTF as a mechanism for template switch in fork rescue by Burkovics, Peter, Sebesta, Marek, Balogh, David, Haracska, Lajos, Krejci, Lumir

“…Stalling of replication forks at unrepaired DNA lesions can result in discontinuities opposite the damage in the newly synthesized DNA strand. Translesion…”
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Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination by Taylor, Martin R.G., Špírek, Mário, Chaurasiya, Kathy R., Ward, Jordan D., Carzaniga, Raffaella, Yu, Xiong, Egelman, Edward H., Collinson, Lucy M., Rueda, David, Krejci, Lumir, Boulton, Simon J.

“…Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes…”
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Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability by Booth, James Alexander, Špírek, Mário, Lobie, Tekle Airgecho, Skarstad, Kirsten, Krejci, Lumir, Bjørås, Magnar

“…Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that…”
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MUS81 cleaves TOP1-derived lesions and other DNA-protein cross-links by Marini, Victoria, Nikulenkov, Fedor, Samadder, Pounami, Juul, Sissel, Knudsen, Birgitta R, Krejci, Lumir

“…DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance,…”
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Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase by Papageorgiou, Anna C., Pospisilova, Michaela, Cibulka, Jakub, Ashraf, Raghib, Waudby, Christopher A., Kadeřávek, Pavel, Maroz, Volha, Kubicek, Karel, Prokop, Zbynek, Krejci, Lumir, Tripsianes, Konstantinos

“…Biomolecular polyelectrolyte complexes can be formed between oppositely charged intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic…”
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Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication by Urulangodi, Madhusoodanan, Sebesta, Marek, Menolfi, Demis, Szakal, Barnabas, Sollier, Julie, Sisakova, Alexandra, Krejci, Lumir, Branzei, Dana

“…Accurate completion of replication relies on the ability of cells to activate error-free recombination-mediated DNA damage bypass at sites of perturbed…”
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Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation by Kolesar, Peter, Sarangi, Prabha, Altmannova, Veronika, Zhao, Xiaolan, Krejci, Lumir

“…The Srs2 DNA helicase of Saccharomyces cerevisiae affects recombination in multiple ways. Srs2 not only inhibits recombination at stalled replication forks but…”
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Role of PCNA and RFC in promoting Mus81-complex activity by Sisakova, Alexandra, Altmannova, Veronika, Sebesta, Marek, Krejci, Lumir

“…Proper DNA replication is essential for faithful transmission of the genome. However, replication stress has serious impact on the integrity of the cell,…”
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Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities by Sebesta, Marek, Burkovics, Peter, Haracska, Lajos, Krejci, Lumir

“…The error-free repair of double-strand DNA breaks by homologous recombination (HR) ensures genomic stability using undamaged homologous sequence to copy…”
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Mitochondrial dysfunction in DDR-related cancer predisposition syndromes by Lyakhovich, Alex, Graifer, Dmitry, Stefanovie, Barbora, Krejci, Lumir

“…Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological…”
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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe by Drápela, Stanislav, Khirsariya, Prashant, Weerden, Wytske M., Fedr, Radek, Suchánková, Tereza, Búzová, Diana, Červený, Jan, Hampl, Aleš, Puhr, Martin, Watson, William R., Culig, Zoran, Krejčí, Lumír, Paruch, Kamil, Souček, Karel

“…As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic…”
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Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination by Prakash, Rohit, Satory, Dominik, Dray, Eloïse, Papusha, Almas, Scheller, Jürgen, Kramer, Wilfried, Krejci, Lumir, Klein, Hannah, Haber, James E, Sung, Patrick, Ira, Grzegorz

“…Eukaryotes possess mechanisms to limit crossing over during homologous recombination, thus avoiding possible chromosomal rearrangements. We show here that…”
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Rad51 Recombinase and Recombination Mediators by Sung, Patrick, Krejci, Lumir, Van Komen, Stephen, Sehorn, Michael G.

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The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis by Burkovics, Peter, Dome, Lili, Juhasz, Szilvia, Altmannova, Veronika, Sebesta, Marek, Pacesa, Martin, Fugger, Kasper, Sorensen, Claus Storgaard, Lee, Marietta Y W T, Haracska, Lajos, Krejci, Lumir

“…Successful and accurate completion of the replication of damage-containing DNA requires mainly recombination and RAD18-dependent DNA damage tolerance pathways…”
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MEK and TGF-beta Inhibition Promotes Reprogramming without the Use of Transcription Factor by Vrbsky, Jan, Tereh, Tamas, Kyrylenko, Sergiy, Dvorak, Petr, Krejci, Lumir

“…The possibility of replacing the originally discovered and widely used DNA reprogramming transcription factors is stimulating enormous effort to identify more…”
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Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans by Sebesta, Marek, Burkovics, Peter, Juhasz, Szilvia, Zhang, Sufang, Szabo, Judit E., Lee, Marietta Y.W.T., Haracska, Lajos, Krejci, Lumir

“…Homologous recombination (HR) is essential for maintaining genomic integrity, which is challenged by a wide variety of potentially lethal DNA lesions…”
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Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association by Sarangi, Prabha, Bartosova, Zdenka, Altmannova, Veronika, Holland, Cory, Chavdarova, Melita, Lee, Sang Eun, Krejci, Lumir, Zhao, Xiaolan

“…The Saccharomyces cerevisiae Rad1-Rad10 complex is a conserved, structure-specific endonuclease important for repairing multiple types of DNA lesions. Upon…”
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