Search Results - "Kreitman, R"

Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study by Subbiah, V., Kreitman, R.J., Wainberg, Z.A., Cho, J.Y., Schellens, J.H.M., Soria, J.C., Wen, P.Y., Zielinski, C.C., Cabanillas, M.E., Boran, A., Ilankumaran, P., Burgess, P., Romero Salas, T., Keam, B.

“…Combined therapy with dabrafenib plus trametinib was approved in several countries for treatment of BRAF V600E-mutant anaplastic thyroid cancer (ATC) based on…”
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Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins by Antignani, A, Segal, D, Simon, N, Kreitman, R J, Huang, D, FitzGerald, D J

“…Protein synthesis is crucial for regulating cell homeostasis and, when unrestricted, it can lead to tumorigenesis. Immunotoxins derived from Pseudomonas…”
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Unexpected hepatitis B virus transmission after liver transplant from nucleic acid testing‐ and serology‐negative liver donors who are hepatitis C viremic by Kreitman, Kyle R., Kothadia, Jiten P., Nair, Satheesh P., Maliakkal, Benedict J.

“…The opioid epidemic has led to increased availability of organs for liver transplantation. The success of direct‐acting antiviral therapy for hepatitis C (HCV)…”
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Updated efficacy and safety data of dabrafenib (D) and trametinib (T) in patients (pts) with BRAF V600E–mutated anaplastic thyroid cancer (ATC) by Keam, B., Kreitman, R.J., Wainberg, Z.A., Cabanillas, M.E., Cho, D.C., Italiano, A., Stein, A., Cho, J.Y., Schellens, J.H.M., Wen, P.Y., Zielinski, C.C., Boran, A.D., Mookerjee, B., Burgess, P., Rangwala, F., Subbiah, V.

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Phase I Trial of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) in Patients With Hematologic Malignancies by KREITMAN, R. J, WILSON, W. H, WHITE, J. D, STETLER-STEVENSON, M, JAFFE, E. S, GIARDINA, S, WALDMANN, T. A, PASTAN, I

“…To evaluate the toxicity, pharmacokinetics, immunogenicity, and antitumor activity of anti-Tac(Fv)-PE38 (LMB-2), an anti-CD25 recombinant immunotoxin that…”
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Intratumoral Administration of Recombinant Circularly Permuted Interleukin-4-Pseudomonas Exotoxin in Patients with High-Grade Glioma by RAND, R. W, KREITMAN, R. J, PATRONAS, N, VARRICCHIO, F, PASTAN, I, PURI, R. K

“…Human glioblastoma but not normal brain cells express numerous receptors for the cytokine interleukin (IL)-4. To target these receptors, we have investigated…”
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Elevation of soluble CD307 (IRTA2 FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma by ISE, T, NAGATA, S, KYLE, R. A, JELINEK, D. F, PASTAN, I, KREITMAN, R. J, WILSON, W. H, WAYNE, A. S, STETLER-STEVENSON, M, BISHOP, M. R, SCHEINBERG, D. A, RASSENTI, L, KIPPS, T. J

“…CD307 is a differentiation antigen expressed in B-lineage cells. One soluble and two membrane-bound forms have been predicted and an enzyme-linked…”
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Targeted Toxins by FRANKEL, A. E, KREITMAN, R. J, SAUSVILLE, E. A

“…Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells…”
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Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function by Kaneko, Satoshi, Hikida, Takatoshi, Watanabe, Dai, Ichinose, Hiroshi, Nagatsu, Toshiharu, Kreitman, Robert J., Pastan, Ira, Nakanishi, Shigetada

“…The physiological role of striatal cholinergic interneurons was investigated with immunotoxin-mediated cell targeting (IMCT). Unilateral cholinergic cell…”
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S3316 Vaccinations in the VA - A Quality Improvement Project to Improve Vaccination Rates in Patients With Inflammatory Bowel Disease on Immunomodulating Agents at a Mid-South VA Hospital by Cheng, Tony, Kreitman, Kyle R., Baidoo, Leonard, Waters, Bradford

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S2337 The Devil Is in the Details: Uncommon Cause of Upper GI Bleed by Cheng, Tony, Kreitman, Kyle R., Aleem, Abdul, Kothadia, Jiten

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Responses in Refractory Hairy Cell Leukemia to a Recombinant Immunotoxin by Kreitman, Robert J., Wilson, Wyndham H., Robbins, David, Margulies, Inger, Stetler-Stevenson, Maryalice, Waldmann, Thomas A., Pastan, Ira

“…We report major responses in 4 of 4 patients with hairy cell leukemia (HCL) who have recently been treated on a phase I trial with the recombinant immunotoxin…”
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Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor by Kreitman, R J, Pastan, I

“…It was previously shown that amino acids 609-613 (REDLK) at the C-terminus of Pseudomonas exotoxin (PE) are necessary for cytotoxicity, presumably by directing…”
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Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia by Kreitman, Robert J, Wilson, Wyndham H, Bergeron, Karen, Raggio, Miranda, Stetler-Stevenson, Maryalice, FitzGerald, David J, Pastan, Ira

“…A genetically engineered molecule to treat resistant hairy-cell leukemia. About 2 percent of cases of leukemia are of the hairy-cell type. 1 , 2 Prominent…”
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Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias by FRANKEL, A. E, MCCUBREY, J. A, KREITMAN, R. J, HOGGE, D. E, MILLER, M. S, DELATTE, S, RAMAGE, J, KISER, M, KUCERA, G. L, ALEXANDER, R. L, BERAN, M, TAGGE, E. P

“…Leukemic blasts from patients with acute phase chronic myeloid leukemic and refractory acute myeloid leukemia are highly resistant to a number of cytotoxic…”
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Toxin-labeled monoclonal antibodies by Kreitman, R J

“…To arm monoclonal antibodies (MAbs) with the power to kill malignant cells, they have been connected to toxins to create chimeric proteins called immunotoxins…”
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Immunotoxins in cancer therapy by Kreitman, Robert J

“…Immunotoxins are composed of a protein toxin connected to a binding ligand such as an antibody or growth factor. These molecules bind to surface antigens…”
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Accumulation of a recombinant immunotoxin in a tumor in vivo : Fewer than 1000 molecules per cell are sufficient for complete responses by KREITMAN, R. J, PASTAN, I

“…Recombinant immunotoxins have been shown to cure human tumor xenografts in mice, but their biodistribution to both tumors and normal organs has not been…”
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Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies by Keppler‐Hafkemeyer, Andrea, Kreitman, Robert J., Pastan, Ira

“…The recombinant immunotoxins anti‐Tac(Fv)‐PE38 (LMB‐2), targeting the interleukin‐2 receptor α subunit (IL‐2Rα, Tac or CD25), and RFB4(dsFv)‐PE38 (BL22),…”
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Cytotoxic Activity of Disulfide-stabilized Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) toward Fresh Malignant Cells from Patients with B-Cell Leukemias by KREITMAN, R. J, MARGULIES, I, STETLER-STEVENSON, M, WANG, Q.-C, FITZGERALD, D. J. P, PASTAN, I

“…Chemical conjugates of anti-CD22 monoclonal antibodies and toxins have been used to treat CD22+ hematological malignancies. A new anti-CD22 recombinant…”
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