Search Results - "Kreir, Mohamed"

The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics by Sancho-Vaello, Enea, Gil-Carton, David, François, Patrice, Bonetti, Eve-Julie, Kreir, Mohamed, Pothula, Karunakar Reddy, Kleinekathöfer, Ulrich, Zeth, Kornelius

“…The human cathelicidin LL-37 serves a critical role in the innate immune system defending bacterial infections. LL-37 can interact with molecules of the cell…”
Get full text

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain by Moparthi, Lavanya, Survery, Sabeen, Kreir, Mohamed, Simonsen, Charlotte, Kjellbom, Per, Högestätt, Edward D., Johanson, Urban, Zygmunt, Peter M.

“…Significance The ability of an organism to detect and avoid noxious temperatures is crucial for survival. It is, therefore, of great interest that several…”
Get full text

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain by Moparthi, Lavanya, Sinica, Viktor, Moparthi, Vamsi K., Kreir, Mohamed, Vignane, Thibaut, Filipovic, Milos R., Vlachova, Viktorie, Zygmunt, Peter M.

“…TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore…”
Get full text

Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel by Itoh, Hiroaki, Matsuoka, Shigeru, Kreir, Mohamed, Inoue, Masayuki

“…We report herein the design, total synthesis, and functional analysis of a novel artificial ion channel molecule, designated as dansylated polytheonamide mimic…”
Get full text

Identifying Acute Cardiac Hazard in Early Drug Discovery Using a Calcium Transient High-Throughput Assay in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Lu, Hua Rong, Kreir, Mohamed, Karel, Van Ammel, Tekle, Fetene, Geyskens, Danny, Teisman, Ard, Gallacher, David J

“…Early identification of cardiac risk is essential for reducing late-stage attrition in drug development. We adapted the previously published cardiac hazard…”
Get full text

Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery by Kreir, Mohamed, Putri, Dea, Tekle, Fetene, Pibiri, Francesca, d'Ydewalle, Constantin, Van Ammel, Karel, Geys, Helena, Teisman, Ard, Gallacher, David J, Lu, Hua Rong

“…We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based…”
Get full text

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease by Vandermeulen, Lina, Geric, Ivana, Fumagalli, Laura, Kreir, Mohamed, Lu, Ashley, Nonneman, Annelies, Premereur, Jessie, Wolfs, Leen, Policarpo, Rafaela, Fattorelli, Nicola, De Bondt, An, Van Den Wyngaert, Ilse, Asselbergh, Bob, Fiers, Mark, De Strooper, Bart, d'Ydewalle, Constantin, Mancuso, Renzo

“…Microglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes predominately or exclusively…”
Get full text

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins by Shaya, David, Kreir, Mohamed, Robbins, Rebecca A, Wong, Stephanie, Hammon, Justus, Brüggemann, Andrea, Minor, Daniel L. Jr

“…Many voltage-gated ion channel (VGIC) superfamily members contain six-transmembrane segments in which the first four form a voltage-sensing domain (VSD) and…”
Get full text

Membrane assembly of the functional KcsA potassium channel in a vesicle-based eukaryotic cell-free translation system by Dondapati, Srujan Kumar, Kreir, Mohamed, Quast, Robert B., Wüstenhagen, Doreen A, Brüggemann, Andrea, Fertig, Niels, Kubick, Stefan

“…The potassium channel KcsA was heterologously expressed in a eukaryotic cell-free system. Both, the expression yields and functional analysis of the protein…”
Get full text

Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies by Shih, Pei-Yu, Kreir, Mohamed, Kumar, Devesh, Seibt, Frederik, Pestana, Francisco, Schmid, Benjamin, Holst, Bjørn, Clausen, Christian, Steeg, Rachel, Fischer, Benjamin, Pita-Almenar, Juan, Ebneth, Andreas, Cabrera-Socorro, Alfredo

“…Neurogenin 2 encodes a neural-specific transcription factor (NGN2) able to drive neuronal fate on somatic and stem cells. NGN2 is expressed in neural…”
Get full text

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose by Lu, Hua Rong, Damiano, Bruce P, Kreir, Mohamed, Rohrbacher, Jutta, van der Linde, Henk, Saidov, Tamerlan, Teisman, Ard, Gallacher, David J

“…Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide…”
Get full text

SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System by Neyrinck, Katrien, Van Den Daele, Johanna, Vervliet, Tim, De Smedt, Jonathan, Wierda, Keimpe, Nijs, Melissa, Vanbokhoven, Tom, D'hondt, Astrid, Planque, Mélanie, Fendt, Sarah-Maria, Shih, Pei-Yu, Seibt, Frederik, Almenar, Juan Pita, Kreir, Mohamed, Kumar, Devesh, Broccoli, Vania, Bultynck, Geert, Ebneth, Andreas, Cabrera-Socorro, Alfredo, Verfaillie, Catherine

“…Astrocytes, the main supportive cell type of the brain, show functional impairments upon ageing and in a broad spectrum of neurological disorders. Limited…”
Get more information

High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca2+ Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures by Lu, Hua-Rong, Seo, Manabu, Kreir, Mohamed, Tanaka, Tetsuya, Yamoto, Rie, Altrocchi, Cristina, van Ammel, Karel, Tekle, Fetene, Pham, Ly, Yao, Xiang, Teisman, Ard, Gallacher, David J.

“…Drug-induced seizure liability is a significant safety issue and the basis for attrition in drug development. Occurrence in late development results in…”
Get full text

Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes by Kreir, Mohamed, Farre, Cecilia, Beckler, Matthias, George, Michael, Fertig, Niels

“…Solvent-free planar lipid bilayers were formed in an automatic manner by bursting of giant unilamellar vesicles (GUVs) after gentle suction application through…”
Get more information

Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching by Billen, Bert, Brams, Marijke, Debaveye, Sarah, Remeeva, Alina, Alpizar, Yeranddy A., Waelkens, Etienne, Kreir, Mohamed, Brüggemann, Andrea, Talavera, Karel, Nilius, Bernd, Voets, Thomas, Ulens, Chris

“…TRPV3 is a thermosensitive ion channel primarily expressed in epithelial tissues of the skin, nose, and tongue. The channel has been implicated in…”
Get full text

Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology by Farre, Cecilia, Haythornthwaite, Alison, Haarmann, Claudia, Stoelzle, Sonja, Kreir, Mohamed, George, Michael, Brüggemann, Andrea, Fertig, Niels

“…Ion channel dysfunction is known to underlie several acute and chronic disorders and, therefore, ion channels have gained increased interest as drug targets…”
Get more information

The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes by Gaßmann, Oliver, Kreir, Mohamed, Ambrosi, Cinzia, Pranskevich, Jennifer, Oshima, Atsunori, Röling, Christian, Sosinsky, Gina, Fertig, Niels, Steinem, Claudia

“…Connexin26 (Cx26) is a member of the connexin family, the building blocks for gap junction intercellular channels. These dodecameric assemblies are involved in…”
Get full text

The translational discrepancy in the assessment of seizure risk for antidepressants and antipsychotics by Kreir, Mohamed, Teuns, Greet, Lu, Hua Rong, Gallacher, David

Get full text

Role of Kv7.2/Kv7.3 and M 1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons by Kreir, Mohamed, De Bondt, An, Van den Wyngaert, Ilse, Teuns, Greet, Lu, Hua Rong, Gallacher, David J

“…The Kv7 family of voltage-dependent non-inactivating potassium channels is composed of five members, of which four are expressed in the CNS. Kv7.2, 7.3 and 7.5…”
Get full text

Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons by Kreir, Mohamed, De Bondt, An, Van den Wyngaert, Ilse, Teuns, Greet, Lu, Hua Rong, Gallacher, David J.

“…The Kv7 family of voltage-dependent non-inactivating potassium channels is composed of five members, of which four are expressed in the CNS. Kv7.2, 7.3 and 7.5…”
Get full text