SepsEast Registry indicates high mortality associated with COVID-19 caused acute respiratory failure in Central-Eastern European intensive care units

The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the...

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Published in:	Scientific reports Vol. 12; no. 1; p. 14906
Main Authors:	Benes, Jan, Jankowski, Miłosz, Szułdrzynski, Konstanty, Zahorec, Roman, Lainscak, Mitja, Ruszkai, Zoltán, Podbregar, Matej, Zatloukal, Jan, Kletecka, Jakub, Kusza, Krzysztof, Szrama, Jakub, Ramic, Estera, Galkova, Katarina, Krbila, Stefan, Valky, Josef, Ivanic, Jaka, Kurnik, Marko, Mikó, Angéla, Kiss, Tamás, Hetényi, Barbara, Hegyi, Peter, Sustic, Alan, Molnar, Zsolt
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-09-2022 Nature Publishing Group Nature Portfolio
Subjects:	692/308 692/308/409 Adult Body mass index Comorbidity Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - therapy Hospitals Humanities and Social Sciences Humans Intensive care Intensive Care Units Male Mechanical ventilation Mortality multidisciplinary Oxygen Oxygenation Pandemics Patients Registries Respiration, Artificial Respiratory Distress Syndrome Respiratory failure Respiratory Insufficiency - epidemiology Respiratory Insufficiency - therapy Retrospective Studies SARS-CoV-2 Science Science (multidisciplinary) Sepsis Sepsis - epidemiology Ventilation
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Summary:	The coronavirus disease (COVID-19) pandemic caused unprecedented research activity all around the world but publications from Central-Eastern European countries remain scarce. Therefore, our aim was to characterise the features of the pandemic in the intensive care units (ICUs) among members of the SepsEast (Central-Eastern European Sepsis Forum) initiative. We conducted a retrospective, international, multicentre study between March 2020 and February 2021. All adult patients admitted to the ICU with pneumonia caused by COVID-19 were enrolled. Data on baseline and treatment characteristics, organ support and mortality were collected. Eleven centres from six countries provided data from 2139 patients. Patient characteristics were: median 68, [IQR 60–75] years of age; males: 67%; body mass index: 30.1 [27.0–34.7]; and 88% comorbidities. Overall mortality was 55%, which increased from 2020 to 2021 (p = 0.004). The major causes of death were respiratory (37%), cardiovascular (26%) and sepsis with multiorgan failure (21%). 1061 patients received invasive mechanical ventilation (mortality: 66%) without extracorporeal membrane oxygenation (n = 54). The rest of the patients received non-invasive ventilation (n = 129), high flow nasal oxygen (n = 317), conventional oxygen therapy (n = 122), as the highest level of ventilatory support, with mortality of 50%, 39% and 22%, respectively. This is the largest COVID-19 dataset from Central-Eastern European ICUs to date. The high mortality observed especially in those receiving invasive mechanical ventilation renders the need of establishing national–international ICU registries and audits in the region that could provide high quality, transparent data, not only during the pandemic, but also on a regular basis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-022-18991-2