Strong Igg Isotypic Antibody Response In Sowdah Type Onchocerciasis

Persons exposed to Onchocerca volvulus express differences in manifestations of onchocerciasis ranging from hyporeactive (generalized) to hyperreactive (sowdah) forms; absence of disease is seen in endemic normal persons. Analysis of the IgG isotypic antibody response to O. volvulus extracts and non...

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Published in:	The Journal of infectious diseases Vol. 170; no. 4; pp. 955 - 961
Main Authors:	Brattig, Norbert W., Krawietz, Iris, Abakar, Adams Z., Erttmann, Klaus D., Kruppa, Thomas F., Massougbodji, Achilles
Format:	Journal Article
Language:	English
Published:	United States The University of Chicago Press 01-10-1994 University of Chicago Press
Subjects:	Antibodies Antibodies, Helminth - blood Antibody Formation Antigen antibody complex Antigens Benin - epidemiology Enzyme-Linked Immunosorbent Assay Eosinophils Humans Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin Isotypes - blood Infections Intestinal volvulus Major Article Onchocerciasis Onchocerciasis - blood Onchocerciasis - epidemiology Onchocerciasis - immunology Parasites Reference Values Skin Benin
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Summary:	Persons exposed to Onchocerca volvulus express differences in manifestations of onchocerciasis ranging from hyporeactive (generalized) to hyperreactive (sowdah) forms; absence of disease is seen in endemic normal persons. Analysis of the IgG isotypic antibody response to O. volvulus extracts and nonparasite ubiquitous antigens in 92 West Africans revealed highest anti-O. volvulus IgG 1 and IgG 2 responses in sowdah, high levels in the generalized form, and low antibody levels in endemic normal persons. Nonexposed persons had no antibodies. A significant IgG3 antibody response was detected only in sowdah, while high IgG4 levels occurred in both polar groups but were absent in both control groups. Isotypic responses to antigens unrelated to O. volvulus were similar in all groups but showed higher IgG 1 and IgG2 levels in sowdah. Sowdah patients had high levels of Ro/SS-A antibodies, circulating immune complexes, and eosinophil cationic protein. These results document a strong B cell response in African sowdah and indicate variations in immune responsiveness.
Bibliography:	Reprints or correspondence: Dr. N. W. Brattig, Dept. ofClinical Chemistry. Bernhard Nocht Institute for Tropical Medicine. Bernhard-Nocht-Str. 74.20359 Hamburg. Germany. istex:90F2D2C14B94290F4931C98360E66B771B93E103 ark:/67375/HXZ-5DJ0ZJN9-6 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/170.4.955