Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling

[Display omitted] •Previously unknown growth phenomenon identified during fine grinding of API.•Particle growth depends on process parameters of the mill.•Grinding media material and size influence physical stability of the product. The production of nanosuspensions has proved to be an effective met...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of pharmaceutics and biopharmaceutics Vol. 92; pp. 171 - 179
Main Authors:	Bitterlich, A., Laabs, C., Krautstrunk, I., Dengler, M., Juhnke, M., Grandeury, A., Bunjes, H., Kwade, A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-05-2015
Subjects:	Chemistry, Pharmaceutical - methods Crystallization Drug Compounding - methods Drug Stability Excipients - chemistry Fine grinding Formulation Media mill Morphology Nanoparticles Nanosuspension Naproxen - administration & dosage Naproxen - chemistry Particle Size Particle technology Poorly water soluble drug Screening Solubility Stabilization Suspensions Nanoparticles Screening Fine grinding Stabilization Morphology Formulation Particle technology Nanosuspension Poorly water soluble drug Media mill
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •Previously unknown growth phenomenon identified during fine grinding of API.•Particle growth depends on process parameters of the mill.•Grinding media material and size influence physical stability of the product. The production of nanosuspensions has proved to be an effective method for overcoming bioavailability challenges of poorly water soluble drugs. Wet milling in stirred media mills and planetary ball mills has become an established top-down-method for producing such drug nanosuspensions. The quality of the resulting nanosuspension is determined by the stability against agglomeration on the one hand, and the process parameters of the mill on the other hand. In order to understand the occurring dependencies, a detailed screening study, not only on adequate stabilizers, but also on their optimum concentration was carried out for the active pharmaceutical ingredient (API) naproxen in a planetary ball mill. The type and concentration of the stabilizer had a pronounced influence on the minimum particle size obtained. With the best formulation the influence of the relevant process parameters on product quality was investigated to determine the grinding limit of naproxen. Besides the well known phenomenon of particle agglomeration, actual naproxen crystal growth and morphology alterations occurred during the process which has not been observed before. It was shown that, by adjusting the process parameters, those effects could be reduced or eliminated. Thus, besides real grinding and agglomeration a process parameter dependent ripening of the naproxen particles was identified to be a concurrent effect during the naproxen fine grinding process.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0939-6411 1873-3441
DOI:	10.1016/j.ejpb.2015.02.031