Search Results - "Krausova, Barbora"

Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor by Hrcka Krausova, Barbora, Kysilov, Bohdan, Cerny, Jiri, Vyklicky, Vojtech, Smejkalova, Tereza, Ladislav, Marek, Balik, Ales, Korinek, Miloslav, Chodounska, Hana, Kudova, Eva, Vyklicky, Ladislav

“…-methyl-D-aspartate receptor (NMDAR) hypofunction has been implicated in several neurodevelopmental disorders. NMDAR function can be augmented by positive…”
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Pregnane‐based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss‐of‐function disease‐associated GRIN mutations by Kysilov, Bohdan, Hrcka Krausova, Barbora, Vyklicky, Vojtech, Smejkalova, Tereza, Korinek, Miloslav, Horak, Martin, Chodounska, Hana, Kudova, Eva, Cerny, Jiri, Vyklicky, Ladislav

“…Background and Purpose N‐methyl‐D‐aspartate receptors (NMDARs) play a critical role in synaptic plasticity, and mutations in human genes encoding NMDAR…”
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Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids by Kysilov, Bohdan, Kuchtiak, Viktor, Hrcka Krausova, Barbora, Balik, Ales, Korinek, Miloslav, Fili, Klevinda, Dobrovolski, Mark, Abramova, Vera, Chodounska, Hana, Kudova, Eva, Bozikova, Paulina, Cerny, Jiri, Smejkalova, Tereza, Vyklicky, Ladislav

“…N -methyl- d -aspartate receptors (NMDARs) play a critical role in normal brain function, and variants in genes encoding NMDAR subunits have been described in…”
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Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms by Smejkalova, Tereza, Korinek, Miloslav, Krusek, Jan, Hrcka Krausova, Barbora, Candelas Serra, Miriam, Hajdukovic, Dragana, Kudova, Eva, Chodounska, Hana, Vyklicky, Ladislav

“…Background and Purpose Neurosteroids influence neuronal function and have multiple promising clinical applications. Direct modulation of postsynaptic…”
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Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors by Skrenkova, Kristyna, Hemelikova, Katarina, Kolcheva, Marharyta, Kortus, Stepan, Kaniakova, Martina, Krausova, Barbora, Horak, Martin

“…N -methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an essential role in mediating excitatory neurotransmission in the…”
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Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity by Hubalkova, Pavla, Ladislav, Marek, Vyklicky, Vojtech, Smejkalova, Tereza, Hrcka Krausova, Barbora, Kysilov, Bohdan, Krusek, Jan, Naimová, Zaneta, Korinek, Miloslav, Chodounska, Hana, Kudova, Eva, Cerny, Jiri, Vyklicky, Jr, Ladislav

“…NMDARs are ligand-gated ion channels that cause an influx of Na and Ca into postsynaptic neurons. The resulting intracellular Ca transient triggers synaptic…”
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Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes by Kortus, Stepan, Rehakova, Kristyna, Klima, Martin, Kolcheva, Marharyta, Ladislav, Marek, Langore, Emily, Barackova, Petra, Netolicky, Jakub, Misiachna, Anna, Hemelikova, Katarina, Humpolickova, Jana, Chalupska, Dominika, Silhan, Jan, Kaniakova, Martina, Hrcka Krausova, Barbora, Boura, Evzen, Zapotocky, Martin, Horak, Martin

“…NMDA receptors (NMDARs) are ionotropic glutamate receptors that play a key role in excitatory neurotransmission. The number and subtype of surface NMDARs are…”
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5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia by Munawar Cheema, Marie, Macakova Kotrbova, Zuzana, Hrcka Krausova, Barbora, Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Kratochvil, Miroslav, Vondrasek, Jiri, Sedlak, David, Balastik, Martin, Kudova, Eva

“…Endogenous neurosteroids (NS) and their synthetic analogs, neuroactive steroids (NAS), are potentially useful drug-like compounds affecting the pathophysiology…”
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Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant by Candelas Serra, Miriam, Kuchtiak, Viktor, Kubik-Zahorodna, Agnieszka, Kysilov, Bohdan, Fili, Klevinda, Hrcka Krausova, Barbora, Abramova, Vera, Dobrovolski, Mark, Harant, Karel, Bozikova, Paulina, Cerny, Jiri, Prochazka, Jan, Kasparek, Petr, Sedlacek, Radislav, Balik, Ales, Smejkalova, Tereza, Vyklicky, Ladislav

“…-Methyl-d-aspartate receptors (NMDARs), encoded by genes, are ionotropic glutamate receptors playing a critical role in synaptic transmission, plasticity, and…”
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Cholesterol modulates open probability and desensitization of NMDA receptors by Korinek, Miloslav, Vyklicky, Vojtech, Borovska, Jirina, Lichnerova, Katarina, Kaniakova, Martina, Krausova, Barbora, Krusek, Jan, Balik, Ales, Smejkalova, Tereza, Horak, Martin, Vyklicky, Ladislav

“…Key points NMDA receptors (NMDARs) are tetrameric cation channels permeable to calcium; they mediate excitatory synaptic transmission in the CNS and their…”
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The pathogenic S688Y mutation in the ligand-binding domain of the GluN1 subunit regulates the properties of NMDA receptors by Skrenkova, Kristyna, Song, Jae-man, Kortus, Stepan, Kolcheva, Marharyta, Netolicky, Jakub, Hemelikova, Katarina, Kaniakova, Martina, Krausova, Barbora Hrcka, Kucera, Tomas, Korabecny, Jan, Suh, Young Ho, Horak, Martin

“…Although numerous pathogenic mutations have been identified in various subunits of N -methyl-D-aspartate receptors (NMDARs), ionotropic glutamate receptors…”
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Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology by Korinek, M, Candelas Serra, M, Abdel Rahman, Fes, Dobrovolski, M, Kuchtiak, V, Abramova, V, Fili, K, Tomovic, E, Hrcka Krausova, B, Krusek, J, Cerny, J, Vyklicky, L, Balik, A, Smejkalova, T

“…N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors critical for synaptic transmission and plasticity, and for the…”
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Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia by Holubova, Kristina, Chvojkova, Marketa, Hrcka Krausova, Barbora, Vyklicky, Vojtech, Kudova, Eva, Chodounska, Hana, Vyklicky, Ladislav, Vales, Karel

“…Evidence from clinical and preclinical studies implicates dysfunction of -methyl- -aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We…”
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Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior by Abramova, Vera, Leal Alvarado, Vanessa, Hill, Martin, Smejkalova, Tereza, Maly, Michal, Vales, Karel, Dittert, Ivan, Bozikova, Paulina, Kysilov, Bohdan, Hrcka Krausova, Barbora, Vyklicky, Vojtech, Balik, Ales, Fili, Klevinda, Korinek, Miloslav, Chodounska, Hana, Kudova, Eva, Ciz, David, Martinovic, Jan, Cerny, Jiri, Bartunek, Petr, Vyklicky, Ladislav

“…Multiple molecular targets have been identified to mediate membrane-delimited and nongenomic effects of natural and synthetic steroids, but the influence of…”
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Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit by Vyklicky, Vojtech, Krausova, Barbora, Cerny, Jiri, Ladislav, Marek, Smejkalova, Tereza, Kysilov, Bohdan, Korinek, Miloslav, Danacikova, Sarka, Horak, Martin, Chodounska, Hana, Kudova, Eva, Vyklicky, Ladislav

“…N-methyl-D-aspartate receptors (NMDARs), glutamate-gated ion channels, mediate signaling at the majority of excitatory synapses in the nervous system. Recent…”
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Study protocol for a cross-sectional online survey investigating patient preferences and experiences of waiting for elective cardiac surgery by Russo, Manuela, Watson, Kathryn, Richards, Katie, Olive, Rachel Rowan, Krausova, Barbora, Kumar, Rashmi, Burridge, Joanna, Goulding, Lucy, Chua, Kia-Chong, Hardy, David, Vassilios, Avlonitis, Kamran, Baig, Bhudia, Sunil, Alia, Noorani, Habib, Khan, Sevdalis, Nick, Petrou, Mario

“…IntroductionBeing on a waiting list for elective (planned) cardiac surgery can be physically and psychologically challenging for patients. Research suggests…”
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Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-d-aspartate Receptors by Kaniakova, Martina, Krausova, Barbora, Vyklicky, Vojtech, Korinek, Miloslav, Lichnerova, Katarina, Vyklicky, Ladislav, Horak, Martin

“…Background: The precise number of NMDA receptors is critical for excitatory neurotransmission. Results: Key amino acid residues within membrane domains…”
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Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N -Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif by Adla, Santosh Kumar, Slavikova, Barbora, Chodounska, Hana, Vyklicky, Vojtech, Ladislav, Marek, Hubalkova, Pavla, Krausova, Barbora, Smejkalova, Tereza, Nekardova, Michaela, Smidkova, Marketa, Monincova, Lenka, Soucek, Radko, Vyklicky, Ladislav, Kudova, Eva

“…Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of -methyl-D-aspartate receptors…”
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Implementation evaluation of staff support and wellbeing programmes at an academic health science centre during COVID-19: study protocol by Krausova, Barbora, Gnanapragasam, Sam Nishanth, Demetriou, Len, Beck, Alison, Pires-Yfantouda, Renata, Docherty, Mary Jane, Sevdalis, Nick

“…Evidence from previous pandemics as well as early evidence from COVID-19 suggests risk of adverse mental health and wellbeing outcomes for healthcare workers…”
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Neuroactive steroids with perfluorobenzoyl group by Černý, Ivan, Buděšínský, Miloš, Pouzar, Vladimír, Vyklický, Vojtěch, Krausová, Barbora, Vyklický, Ladislav

“…► New type of neuroactive steroids for photoaffinity labeling were designed. ► Steroid perfluorobenzoates and perfluorobenzamides were synthesized. ►…”
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