Search Results - "Krause, Jens C."

A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates by Krammer, Florian, Margine, Irina, Tan, Gene S, Pica, Natalie, Krause, Jens C, Palese, Peter

“…Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such,…”
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Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus by Xu, Rui, Ekiert, Damian C, Krause, Jens C, Hai, Rong, Crowe, James E. Jr, Wilson, Ian A

“…The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows…”
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A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin by Xu, Rui, Krause, Jens C, McBride, Ryan, Paulson, James C, Crowe, James E, Wilson, Ian A

“…Influenza virus hemagglutinin (HA) binds to sialic acid receptors on the host cell, but receptor analogs have failed as viral-entry inhibitors. Now crystal…”
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A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin by KRAUSE, Jens C, TSIBANE, Tshidi, TUMPEY, Terrence M, HUFFMAN, Chelsey J, BASLER, Christopher F, CROWE, James E

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Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses by Pica, Natalie, Hai, Rong, Krammer, Florian, Wang, Taia T., Maamary, Jad, Eggink, Dirk, Tan, Gene S., Krause, Jens C., Moran, Thomas, Stein, Cheryl R., Banach, David, Wrammert, Jens, Belshe, Robert B., García-Sastre, Adolfo, Palese, Peter

“…After the emergence of pandemic influenza viruses in 1957, 1968, and 2009, existing seasonal viruses were observed to be replaced in the human population by…”
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Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site by Hong, Minsun, Lee, Peter S, Hoffman, Ryan M B, Zhu, Xueyong, Krause, Jens C, Laursen, Nick S, Yoon, Sung-Il, Song, Langzhou, Tussey, Lynda, Crowe, Jr, James E, Ward, Andrew B, Wilson, Ian A

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Specificity for human hemoglobin enhances Staphylococcus aureus infection by Pishchany, Gleb, McCoy, Amanda L, Torres, Victor J, Krause, Jens C, Crowe, Jr, James E, Fabry, Mary E, Skaar, Eric P

“…Iron is required for bacterial proliferation, and Staphylococcus aureus steals this metal from host hemoglobin during invasive infections. This process…”
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Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses by Tsibane, Tshidi, Ekiert, Damian C, Krause, Jens C, Martinez, Osvaldo, Crowe, Jr, James E, Wilson, Ian A, Basler, Christopher F

“…Most monoclonal antibodies (mAbs) to the influenza A virus hemagglutinin (HA) head domain exhibit very limited breadth of inhibitory activity due to antigenic…”
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Recombinant IgA Is Sufficient To Prevent Influenza Virus Transmission in Guinea Pigs by Seibert, Christopher W, Rahmat, Saad, Krause, Jens C, Eggink, Dirk, Albrecht, Randy A, Goff, Peter H, Krammer, Florian, Duty, J Andrew, Bouvier, Nicole M, García-Sastre, Adolfo, Palese, Peter

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Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence by Krause, Jens C, Tsibane, Tshidi, Tumpey, Terrence M, Huffman, Chelsey J, Briney, Bryan S, Smith, Scott A, Basler, Christopher F, Crowe, Jr, James E

“…We generated from a single blood sample five independent human mAbs that recognized the Sa antigenic site on the head of influenza hemagglutinin and exhibited…”
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Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses by KRAUSE, Jens C, TUMPEY, Terrence M, HUFFMAN, Chelsey J, MCGRAW, Patricia A, PEARCE, Melissa B, TSIBANE, Tshidi, RONG HAI, BASLER, Christopher F, CROWE, James E

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Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses by Krause, Jens C, Tsibane, Tshidi, Tumpey, Terrence M, Huffman, Chelsey J, Albrecht, Randy, Blum, David L, Ramos, Irene, Fernandez-Sesma, Ana, Edwards, Kathryn M, García-Sastre, Adolfo, Basler, Christopher F, Crowe, Jr, James E

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Very Late-Onset Group B Streptococcus Meningitis, Sepsis, and Systemic Shigellosis due to Interleukin-1 Receptor-Associated Kinase-4 Deficiency by Krause, Jens C., Ghandil, Pegah, Chrabieh, Maya, Casanova, Jean-Laurent, Picard, Capucine, Puel, Anne, Creech, C. Buddy

“…We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells…”
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An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody by Krause, Jens C, Ekiert, Damian C, Tumpey, Terrence M, Smith, Patricia B, Wilson, Ian A, Crowe, Jr, James E

“…The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here, we demonstrate that a naturally occurring…”
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Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A Hemagglutinin Globular Head by Krause, Jens C, Crowe, Jr, James E

“…The globular head of the trimeric influenza hemagglutinin (HA) contains the receptor-binding domain (RBD) and is the target of potently neutralizing human…”
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Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes by Melendi, Guillermina A, Polack, Fernando P, Monsalvo, Ana Clara, Batalle, Juan P, Lopez, M Florencia, Krause, Jens C, Klemenc, Jennifer, Hernandez, Johanna Zea, Maskin, Bernardo, Bugna, Jimena, Rubinstein, Carlos, Aguilar, Leandro, Dalurzo, Liliana, Libster, Romina, Savy, Vilma, Baumeister, Elsa, Aguilar, Liliana, Cabral, Graciela, Font, Julia, Solari, Liliana, Weller, Kevin P, Johnson, Joyce, Echavarria, Marcela, Edwards, Kathryn M, Chappell, James D, Crowe, James E, Williams, John V

“…Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe…”
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Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency by Picard, Capucine, von Bernuth, Horst, Ghandil, Pegah, Chrabieh, Maya, Levy, Ofer, Arkwright, Peter D., McDonald, Douglas, Geha, Raif S., Takada, Hidetoshi, Krause, Jens C., Creech, C. Buddy, Ku, Cheng-Lung, Ehl, Stephan, Maródi, László, Al-Muhsen, Saleh, Al-Hajjar, Sami, Al-Ghonaium, Abdulaziz, Day-Good, Noorbibi K., Holland, Steven M., Gallin, John I., Chapel, Helen, Speert, David P., Rodriguez-Gallego, Carlos, Colino, Elena, Garty, Ben-Zion, Roifman, Chaim, Hara, Toshiro, Yoshikawa, Hideto, Nonoyama, Shigeaki, Domachowske, Joseph, Issekutz, Andrew C., Tang, Mimi, Smart, Joanne, Zitnik, Simona Eva, Hoarau, Cyrille, Kumararatne, Dinakantha S., Thrasher, Adrian J., Davies, E. Graham, Bethune, Claire, Sirvent, Nicolas, de Ricaud, Dominique, Camcioglu, Yildiz, Vasconcelos, Júlia, Guedes, Margarida, Vitor, Artur Bonito, Rodrigo, Carlos, Almazán, Francisco, Méndez, Maria, Aróstegui, Juan Ignacio, Alsina, Laia, Fortuny, Claudia, Reichenbach, Janine, Verbsky, James W., Bossuyt, Xavier, Doffinger, Rainer, Abel, Laurent, Puel, Anne, Casanova, Jean-Laurent

“…Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)-…”
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Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site by Wen, Xiaolin, Krause, Jens C, Leser, George P, Cox, Reagan G, Lamb, Robert A, Williams, John V, Crowe, James E, Jardetzky, Theodore S

“…The crystal structure of the fusion protein from human metapneumovirus in complex with a potently neutralizing antibody reveals a novel antigenic site, which…”
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Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses by Thornburg, Natalie J, Nannemann, David P, Blum, David L, Belser, Jessica A, Tumpey, Terrence M, Deshpande, Shyam, Fritz, Gloria A, Sapparapu, Gopal, Krause, Jens C, Lee, Jeong Hyun, Ward, Andrew B, Lee, David E, Li, Sheng, Winarski, Katie L, Spiller, Benjamin W, Meiler, Jens, Crowe, Jr, James E

“…Recent studies described the experimental adaptation of influenza H5 HAs that confers respiratory droplet transmission (rdt) to influenza virus in ferrets…”
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Metabolic abnormalities in human immunodeficiency virus-infected children: two-year follow-up by Krause, Jens C, Toye, Mary P, Fisher, Donna J, Stechenberg, Barbara W, Reiter, Edward O, Allen, Holley F

“…HIV-associated lipodystrophy (LD) manifests with fat maldistribution, dyslipidemia, and insulin resistance in some HIV-infected children on antiretroviral…”
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