Search Results - "Krause, Guenter"

Cell line‐based assessment of BTK inhibitors by Krause, Günter, Hassenrück, Floyd, Hallek, Michael

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Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib by Krause, Günter, Hassenrück, Floyd, Hallek, Michael

“…On the occasion of its recent approval for relapsed follicular lymphoma, we review the design and development of the pan-class I PI3K inhibitor copanlisib as a…”
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Comparison of the in vitro effects of the anti‐CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells by Patz, Michaela, Isaeva, Polina, Forcob, Nche, Müller, Bianka, Frenzel, Lukas P., Wendtner, Clemens‐Martin, Klein, Christian, Umana, Pablo, Hallek, Michael, Krause, Günter

“…Summary The effects of two CD20 antibodies, namely rituximab, the current standard for treatment of chronic lymphocytic leukaemia (CLL) in combination with…”
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Relevant Cytokines in the B Cell Lymphoma Micro-Environment by Krause, Günter, Hassenrück, Floyd, Hallek, Michael

“…Cytokines are soluble protein factors with importance in intercellular communication and, as such, play pivotal roles in the pathogenesis of B cell…”
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Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor by Reinart, Nina, Nguyen, Phuong-Hien, Boucas, Jorge, Rosen, Natascha, Kvasnicka, Hans-Michael, Heukamp, Lukas, Rudolph, Cornelia, Ristovska, Vangica, Velmans, Tanja, Mueller, Carolin, Reiners, Katrin S., von Strandmann, Elke Pogge, Krause, Günter, Montesinos-Rongen, Manuel, Schlegelberger, Brigitte, Herling, Marco, Hallek, Michael, Fingerle-Rowson, Günter

“…Survival of chronic lymphocytic leukemia (CLL) cells depends on stimuli provided by a suitable microenvironment. The factors and mechanisms providing this…”
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Efficacy of phosphatidylinositol‐3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells by Göckeritz, Elisa, Kerwien, Susan, Baumann, Michael, Wigger, Marion, Vondey, Verena, Neumann, Lars, Landwehr, Thomas, Wendtner, Clemens M., Klein, Christian, Liu, Ningshu, Hallek, Michael, Frenzel, Lukas P., Krause, Günter

“…Pharmacological inhibition of phosphatiylinositide‐3‐kinase (PI3K)‐mediated signaling holds great promise for treating chronic lymphocytic leukemia (CLL)…”
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Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro‐environmental dialogue by Göckeritz, Elisa, Vondey, Verena, Guastafierro, Anna, Pizevska, Maja, Hassenrück, Floyd, Neumann, Lars, Hallek, Michael, Krause, Günter

“…Summary To elucidate their mechanism of action, inhibitors of Bruton tyrosine kinase (BTK) and resistant BTK mutants were employed to dissect target‐dependent…”
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miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia by Pallasch, Christian Philipp, Patz, Michaela, Park, Yoon Jung, Hagist, Susanne, Eggle, Daniela, Claus, Rainer, Debey-Pascher, Svenja, Schulz, Alexandra, Frenzel, Lukas P., Claasen, Julia, Kutsch, Nadine, Krause, Günter, Mayr, Christine, Rosenwald, Andreas, Plass, Christoph, Schultze, Joachim L., Hallek, Michael, Wendtner, Clemens-Martin

“…MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia…”
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Sensitive Detection of the Natural Killer Cell-Mediated Cytotoxicity of Anti-CD20 Antibodies and Its Impairment by B-Cell Receptor Pathway Inhibitors by Krause, Günter, Hallek, M., Herter, Sylvia, Neumann, Lars, Vondey, Verena, Midda, Safi Hasan, Göckeritz, Elisa, Knödgen, Eva, Hassenrück, Floyd, Klein, Christian

“…The antibody-dependent cell-mediated cytotoxicity (ADCC) of the anti-CD20 monoclonal antibodies (mAbs) rituximab and obinutuzumab against the cell line Raji…”
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Cytotoxicity of the CD37 antibody BI 836826 against chronic lymphocytic leukaemia cells in combination with chemotherapeutic agents or PI3K inhibitors by Krause, Günter, Baki, Imaan, Kerwien, Susan, Knödgen, Eva, Neumann, Lars, Göckeritz, Elisa, Landwehr, Thomas, Heider, Karl‐Heinz, Hallek, Michael

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Total Synthesis of Indole-Derived Allocolchicine Analogues Exhibiting Strong Apoptosis-Inducing Activity by Sitnikov, Nikolay, Velder, Janna, Abodo, Liliane, Cuvelier, Nicole, Neudörfl, Jörg, Prokop, Aram, Krause, Günter, Fedorov, Aleksey Y., Schmalz, Hans-Günther

“…A series of novel pyrrolo‐allocolchicine derivatives (containing a 1‐methyl‐1H‐indol‐5‐yl moiety replacing ring C) was synthesized. The tetracyclic ring system…”
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Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ by Hassenrück, Floyd, Farina-Morillas, Maria, Neumann, Lars, Landini, Francesco, Blakemore, Stuart James, Rabipour, Mina, Alvarez-Idaboy, Juan Raul, Pallasch, Christian P., Hallek, Michael, Rebollido-Rios, Rocio, Krause, Günter

“…Targeting the PI3K isoform p110δ against B cell malignancies is at the mainstay of PI3K inhibitor (PI3Ki) development. Therefore, we generated isogenic cell…”
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On the assessment of dasatinib-induced autophagy in CLL by Krause, Günter, Hallek, Michael

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Comparison of the effects of two kinase inhibitors, sorafenib and dasatinib, on chronic lymphocytic leukemia cells by Kuckertz, Mirjam, Patz, Michaela, Veldurthy, Aditya, Gehrke, Iris, Claasen, Julia, Frenzel, Lukas P, Wendtner, Clemens-Martin, Hallek, Michael, Krause, Günter

“…With sorafenib displaying the highest affinities for Flt3, VEGFR (vascular endothelial growth factor receptor) and Raf and dasatinib for Abl and Src kinases,…”
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Macrophage Migration Inhibitory Factor (MIF) Promotes the Development of Murine Chronic Lymphocytic Leukemia (CLL) by Reinart, Nina, Ciesla, Malgorzata, Rudolph, Cornelia, Stein, Astrid, Krause, Guenter, Schlegelberger, Brigitte, Hallek, Michael, Fingerle-Rowson, Guenter

“…Introduction: Tumor formation results from a complex interplay between genetic/epigenetic alterations, cell cycle dysregulation and promotion by the tumor…”
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Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner by Mitina, Olga, Warmuth, Markus, Krause, Günter, Hallek, Michael, Obermeier, Axel

“…The receptor tyrosine kinase (RTK) Flt3 is expressed in early hematopoietic progenitor cells and stimulates their growth. Due to frequent mutations in the Flt3…”
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An Acidic Peptide Inhibits the Interleukin-6-Induced Activities of the Src Family Kinases Hck, Lyn and Fyn in Myeloma Cells by Hausherr, Amparo, Tavares, Rosario, Hallek, Michael, Krause, Guenter F.

“…Background: Src Family Kinases (SFKs) play pivotal roles in normal B-cell development and in B-cell neoplasias. Our aim is to elucidate the roles of SFKs in…”
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Role of p21(WAF1/CIP1) as an attenuator of both proliferative and drug-induced apoptotic signals in BCR-ABL-transformed hematopoietic cells by Forster, Karin, Obermeier, Axel, Mitina, Olga, Simon, Nicola, Warmuth, Markus, Krause, Günter, Hallek, Michael

“…The constitutive tyrosine kinase activity of the BCR-ABL fusion protein plays a crucial role in the pathogenesis of chronic myeloid leukemia and promotes…”
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CILANSETRON IMPROVES HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH DIARRHEA PREDOMINANCE (IBS-D): 849 by Olden, Kevin W., Drossman, Douglas A., Carter, Frederick, Caras, Steven, Krause, Guenter, Steinborn, Claus

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CILANSETRON IN IRRITABLE BOWEL SYNDROME WITH DIARRHEA PREDOMINANCE (IBS-D): EFFICACY AND SAFETY IN A 3 MONTH US STUDY by Miner, Philip, Stanton, David B., Carter, Fred, Caras, Steven, Krause, Guenter, Steinborn, Claus

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