Search Results - "Krause, B.R"

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action by Haubenwallner, S, Essenburg, A.D., Barnett, B.C., Pape, M.E., DeMattos, R.B., Krause, B.R., Minton, L.L., Auerbach, B.J., Newton, R.S., Leff, T

“…For the last 30 years fibrates have been widely prescribed to treat human dyslipidemia. However, the primary mechanism by which they lower plasma lipid levels…”
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Opposite effects of bezafibrate and gemfibrozil in both normal and hypertriglyceridemic rats by Krause, B.R., Barnett, B.C., Essenburg, A.D., Kieft, K.A., Auerbach, B.J., Bousley, R., Stanfield, R., Newton, R.S., Bisgaier, C.L.

“…Chow and sucrose-fed rats were used as animal models to study the dose-responses of bezafibrate and gemfibrozil in normolipidemic and hypertriglyceridemic…”
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ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization by Cases, S. (University of California, San Francisco, CA.), Novak, S, Zheng, Y.W, Myers, H.M, Lear, S.R, Sande, E, Welch, C.B, Lusis, A.J, Spencer, T.A, Krause, B.R

“…The synthesis of cholesterol esters by acyl-CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) is an important component of cellular cholesterol homeostasis…”
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Atherosclerotic lesion development in hypercholesterolemic Japanese quail following probucol treatment: a biochemical and morphologic evaluation by Bocan, T M, Mazur, M J, Mueller, S B, Charlton, G, Kieft, K A, Krause, B R

“…Probucol, a cholesterol-lowering agent which possesses antioxidant properties, was evaluated in hypercholesterolemic Japanese quail in order to assess the…”
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Avasimibe inhibition of aortic acyl-coenzyme A: Cholesterol acyl transferase detected in vivo with pyrenenonanoic acid in LDL-receptor (−/−) mice by Homan, R., Anderson, M.K., Bousley, R., Brammer, D., Krause, B.R.

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Treatment of endogenous hypercholesterolemic rabbits with CI-1027, a novel lipid regulator, results in significantly increased HDL-C and decreased LDL-C by Auerbach, B.J, Dash, D, Bousley, D, Davila-Delgado, E, Essenburg, A, Krause, B.R

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Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolase by Krause, B.R, Sliskovic, D.R, Anderson, M, Homan, R

“…WAY‐121,898 is an inhibitor of pancreatic cholesteryl ester hydrolase (pCEH). After confirming its in vitro potency and relative lack of a major effect on…”
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CI-1027 reduces elevated Lp(a) concentrations in cynomolgus monkeys and Lp(a) transgenic mice by Auerbach, B.J., Bousley, R., Dash, D., Bisgaier, C.L., Essenburg, A.D., McGuire, E., Manca, D., Radulovic, L., Gibson, D., Krause, B.R., Keiser, J.A.

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Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates by Lee, H.T, Roark, W.H, Picard, J.A, Sliskovic, D.R, Roth, B.D, Stanfield, R.L, Hamelehle, K.L, Bousley, R.F, Krause, B.R

“…Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships…”
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Adipose tissue and cholesterol metabolism by Krause, B.R, Hartman, A.D

“…Adipose tissue in man is a major site for cholesterol storage. In obesity over half of total body cholesterol may reside within this tissue; however,…”
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Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. The synthesis and biological activity of a series of malonester amides by Sliskovic, D.R., Picard, J.A., Roark, W.H., Essenburg, A.D., Krause, B.R., Minton, L.L., Reindel, J.F., Stanfield, R.L.

“…The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s, was shown to be a…”
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Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents 14. synthesis and structure-activity relationships of a novel series of sulfonamide tetrazoles by Lee, H.T., Sliskovic, D.R., Stanfield, R.L., Hamelehle, K.L., Bousley, R.F., Krause, B.R.

“…The syntheses and biological activities of a series of novel sulfonamide tetrazole derivatives are reported. The ability of these compounds to inhibit ACAT is…”
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Lipoproteins and apolipoproteins in peripheral lymph of normal and cholesterol-fed dogs by Sloop, C H, Dory, L, Krause, B R, Castle, C, Roheim, P S

“…Prenodal peripheral lymph was used as a model of interstitial fluid to obtain information on the composition of lipoproteins and apolipoproteins which are in…”
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A single high-cholesterol, high-fat meal preferentially increases low molecular weight apolipoprotein B concentration in rat plasma by DeLamatre, J.G, Krause, B.R, Wong, L, Hoffmeier, C.A, Roheim, P.S

“…Rats were fed either rat chow (control), chow + 20% olive oil (olive oil), or chow + 20% olive oil + 2% cholesterol (olive oil/cholesterol) as a single meal to…”
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Adipocyte cholesterol storage: effect of starvation by Krause, B R, Balzer, M, Hartman, A D

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