Search Results - "Kraus, Johann M"

Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish by Reichwald, Kathrin, Petzold, Andreas, Koch, Philipp, Downie, Bryan R., Hartmann, Nils, Pietsch, Stefan, Baumgart, Mario, Chalopin, Domitille, Felder, Marius, Bens, Martin, Sahm, Arne, Szafranski, Karol, Taudien, Stefan, Groth, Marco, Arisi, Ivan, Weise, Anja, Bhatt, Samarth S., Sharma, Virag, Kraus, Johann M., Schmid, Florian, Priebe, Steffen, Liehr, Thomas, Görlach, Matthias, Than, Manuel E., Hiller, Michael, Kestler, Hans A., Volff, Jean-Nicolas, Schartl, Manfred, Cellerino, Alessandro, Englert, Christoph, Platzer, Matthias

“…The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast…”
Get full text

The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination by Mühlenbruch, Lena, Abou-Kors, Tsima, Dubbelaar, Marissa L., Bichmann, Leon, Kohlbacher, Oliver, Bens, Martin, Thomas, Jaya, Ezić, Jasmin, Kraus, Johann M., Kestler, Hans A., von Witzleben, Adrian, Mytilineos, Joannis, Fürst, Daniel, Engelhardt, Daphne, Doescher, Johannes, Greve, Jens, Schuler, Patrick J., Theodoraki, Marie-Nicole, Brunner, Cornelia, Hoffmann, Thomas K., Rammensee, Hans-Georg, Walz, Juliane S., Laban, Simon

“…Background The immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and efficacy of…”
Get full text

Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer-Results of the prospective multicenter PERMAD trial by Seufferlein, Thomas, Lausser, Ludwig, Stein, Alexander, Arnold, Dirk, Prager, Gerald, Kasper-Virchow, Stefan, Niedermeier, Michael, Müller, Lothar, Kubicka, Stefan, König, Alexander, Büchner-Steudel, Petra, Wille, Kai, Berger, Andreas W, Kestler, Angelika M R, Kraus, Johann M, Werle, Silke D, Perkhofer, Lukas, Ettrich, Thomas J, Kestler, Hans A

“…Anti-vascular endothelial growth factor (VEGF) monoclonal antibodies (mAbs) are widely used for tumor treatment, including metastatic colorectal cancer (mCRC)…”
Get full text

Digitalization of adverse event management in oncology to improve treatment outcome—A prospective study protocol by Kestler, Angelika M. R, Kühlwein, Silke D, Kraus, Johann M, Schwab, Julian D, Szekely, Robin, Thiam, Patrick, Hühne, Rolf, Jahn, Niels, Fürstberger, Axel, Ikonomi, Nensi, Balig, Julien, Schuler, Rainer, Kuhn, Peter, Steger, Florian, Seufferlein, Thomas, Kestler, Hans A

“…The occurrence of adverse events frequently accompanies tumor treatments. Side effects should be detected and treated as soon as possible to maintain the best…”
Get full text

Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens by Abou Kors, Tsima, Meier, Matthias, Mühlenbruch, Lena, Betzler, Annika C, Oliveri, Franziska, Bens, Martin, Thomas, Jaya, Kraus, Johann M, Doescher, Johannes, von Witzleben, Adrian, Hofmann, Linda, Ezic, Jasmin, Huber, Diana, Benckendorff, Julian, Barth, Thomas F E, Greve, Jens, Schuler, Patrick J, Brunner, Cornelia, Blackburn, Jonathan M, Hoffmann, Thomas K, Ottensmeier, Christian, Kestler, Hans A, Rammensee, Hans-Georg, Walz, Juliane S, Laban, Simon

“…The human leukocyte antigen complex (HLA) is essential for inducing specific immune responses to cancer by presenting tumor-associated peptides (TAP) to T…”
Get full text

YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion by Tharehalli, Umesh, Svinarenko, Michael, Kraus, Johann M, Kühlwein, Silke D, Szekely, Robin, Kiesle, Ute, Scheffold, Annika, Barth, Thomas F E, Kleger, Alexander, Schirmbeck, Reinhold, Kestler, Hans A, Seufferlein, Thomas, Oswald, Franz, Katz, Sarah-Fee, Lechel, André

“…Liver cholestasis is a chronic liver disease and a major health problem worldwide. Cholestasis is characterised by a decrease in bile flow due to impaired…”
Get full text

Predicting Variabilities in Cardiac Gene Expression with a Boolean Network Incorporating Uncertainty by Grieb, Melanie, Burkovski, Andre, Sträng, J Eric, Kraus, Johann M, Groß, Alexander, Palm, Günther, Kühl, Michael, Kestler, Hans A

“…Gene interactions in cells can be represented by gene regulatory networks. A Boolean network models gene interactions according to rules where gene expression…”
Get full text

Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma by Barth, Thomas F. E., Kraus, Johann M., Lausser, Ludwig, Flossbach, Lucia, Schulte, Lukas, Holzmann, Karlheinz, Kestler, Hans A., Möller, Peter

“…Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared…”
Get full text

Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers by Huber, Lisa T, Kraus, Johann M, Ezić, Jasmin, Wanli, Amin, Groth, Marco, Laban, Simon, Hoffmann, Thomas K, Wollenberg, Barbara, Kestler, Hans A, Brunner, Cornelia

“…Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named…”
Get full text

TraqBio - Flexible Progress Tracking for Core Unit Projects by Völkel, Gunnar, Wiese, Sebastian, Holzmann, Karlheinz, Kraus, Johann M, Schneider, Fabian, Görlach, Matthias, Kestler, Hans A

“…Core service units have become an organisational hallmark in many research institutions world wide. Such service cores provide complex state-of-the-art…”
Get full text

VennMaster: area-proportional Euler diagrams for functional GO analysis of microarrays by Kestler, Hans A, Müller, André, Kraus, Johann M, Buchholz, Malte, Gress, Thomas M, Liu, Hongfang, Kane, David W, Zeeberg, Barry R, Weinstein, John N

“…Microarray experiments generate vast amounts of data. The functional context of differentially expressed genes can be assessed by querying the Gene Ontology…”
Get full text

Identification of dynamic driver sets controlling phenotypical landscapes by Werle, Silke D., Ikonomi, Nensi, Schwab, Julian D., Kraus, Johann M., Weidner, Felix M., Rudolph, K. Lenhard, Pfister, Astrid S., Schuler, Rainer, Kühl, Michael, Kestler, Hans A.

“…[Display omitted] Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes highly demanding because cellular decisions…”
Get full text

A highly efficient multi-core algorithm for clustering extremely large datasets by Kraus, Johann M, Kestler, Hans A

“…In recent years, the demand for computational power in computational biology has increased due to rapidly growing data sets from microarray and other…”
Get full text

Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice by Armacki, Milena, Polaschek, Sandra, Waldenmaier, Mareike, Morawe, Mareen, Ruhland, Claudia, Schmid, Rebecca, Lechel, André, Tharehalli, Umesh, Steup, Christoph, Bektas, Yasin, Li, Hongxia, Kraus, Johann M., Kestler, Hans A., Kruger, Stephan, Ormanns, Steffen, Walther, Paul, Eiseler, Tim, Seufferlein, Thomas

“…Pancreatic tumor cells release small extracellular vesicles (sEVs, exosomes) that contain lipids and proteins, RNA, and DNA molecules that might promote…”
Get full text

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation by Chen, Zhiyang, Amro, Elias Moris, Becker, Friedrich, Hölzer, Martin, Rasa, Seyed Mohammad Mahdi, Njeru, Sospeter Ngoci, Han, Bing, Di Sanzo, Simone, Chen, Yulin, Tang, Duozhuang, Tao, Si, Haenold, Ronny, Groth, Marco, Romanov, Vasily S, Kirkpatrick, Joanna M, Kraus, Johann M, Kestler, Hans A, Marz, Manja, Ori, Alessandro, Neri, Francesco, Morita, Yohei, Rudolph, K Lenhard

“…Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely…”
Get full text

Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor by Münch, Vera, Trentin, Luca, Herzig, Julia, Demir, Salih, Seyfried, Felix, Kraus, Johann M., Kestler, Hans A., Köhler, Rolf, Barth, Thomas F.E., te Kronnie, Geertruy, Debatin, Klaus-Michael, Meyer, Lüder H.

“…In acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is a major clinical concern. Despite nondetectable CNS leukemia in many cases,…”
Get full text

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals by Schwörer, Simon, Becker, Friedrich, Feller, Christian, Baig, Ali H., Köber, Ute, Henze, Henriette, Kraus, Johann M., Xin, Beibei, Lechel, André, Lipka, Daniel B., Varghese, Christy S., Schmidt, Manuel, Rohs, Remo, Aebersold, Ruedi, Medina, Kay L., Kestler, Hans A., Neri, Francesco, von Maltzahn, Julia, Tümpel, Stefan, Rudolph, K. Lenhard

“…Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a…”
Get full text

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer by Gout, Johann, Perkhofer, Lukas, Morawe, Mareen, Arnold, Frank, Ihle, Michaela, Biber, Stephanie, Lange, Sebastian, Roger, Elodie, Kraus, Johann M, Stifter, Katja, Hahn, Stephan A, Zamperone, Andrea, Engleitner, Thomas, Müller, Martin, Walter, Karolin, Rodriguez-Aznar, Eva, Sainz, Jr, Bruno, Hermann, Patrick C, Hessmann, Elisabeth, Müller, Sebastian, Azoitei, Ninel, Lechel, André, Liebau, Stefan, Wagner, Martin, Simeone, Diane M, Kestler, Hans A, Seufferlein, Thomas, Wiesmüller, Lisa, Rad, Roland, Frappart, Pierre-Olivier, Kleger, Alexander

“…(ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC)…”
Get more information

PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways by Kaistha, Brajesh P, Lorenz, Holger, Schmidt, Harald, Sipos, Bence, Pawlak, Michael, Gierke, Berthold, Kreider, Ramona, Lankat-Buttgereit, Brigitte, Sauer, Melanie, Fiedler, Lisa, Krattenmacher, Anja, Geisel, Bettina, Kraus, Johann M, Frese, Kristopher K, Kelkenberg, Sabine, Giese, Nathalia A, Kestler, Hans A, Gress, Thomas M, Buchholz, Malte

“…Pancreatic ductal adenocarcinoma (PDAC) carries the most dismal prognosis of all solid tumors and is generally strongly resistant to currently available chemo-…”
Get full text

Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) – A single-cell RNA sequencing analysis by von Witzleben, Adrian, Grages, Ayla, Thomas, Jaya, Ezić, Jasmin, Brunner, Cornelia, Schuler, Patrick J., Kraus, Johann M., Kestler, Hans A., Vahl, Julius M., Doescher, Johannes, King, Emma V., Ottensmeier, Christian H., Hoffmann, Thomas K., Laban, Simon

“…•Significant differences in ICM expression on TILs between HPVpos and HPVneg OPSCC.•Different immune-therapeutic strategies may be needed managing HPVpos…”
Get full text