Search Results - "Krauß, Sybille"

The dynamic world of RNA: beyond translation to subcellular localization and function by Reisbitzer, Annika, Krauß, Sybille

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Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model by Reichenbach, Nicole, Delekate, Andrea, Plescher, Monika, Schmitt, Franziska, Krauss, Sybille, Blank, Nelli, Halle, Annett, Petzold, Gabor C

“…Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood. We…”
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Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease by Schilling, Judith, Broemer, Meike, Atanassov, Ilian, Duernberger, Yvonne, Vorberg, Ina, Dieterich, Christoph, Dagane, Alina, Dittmar, Gunnar, Wanker, Erich, van Roon-Mom, Willeke, Winter, Jennifer, Krauß, Sybille

“…Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin (HTT) gene, translating into an elongated polyglutamine stretch. In addition to…”
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Low Molecular Weight Inhibitors Targeting the RNA-Binding Protein HuR by Joseph, Benjamin Philipp, Weber, Verena, Knüpfer, Lisa, Giorgetti, Alejandro, Alfonso-Prieto, Mercedes, Krauß, Sybille, Carloni, Paolo, Rossetti, Giulia

“…The RNA-binding protein human antigen R (HuR) regulates stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs. This protein has been…”
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Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex by Schweiger, Susann, Matthes, Frank, Posey, Karen, Kickstein, Eva, Weber, Stephanie, Hettich, Moritz M., Pfurtscheller, Sandra, Ehninger, Dan, Schneider, Rainer, Krauß, Sybille

“…The formation of paired helical filaments (PHF), which are composed of hyperphosphorylated Tau protein dissociating from microtubules, is one of the…”
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Role and Perspective of Molecular Simulation-Based Investigation of RNA–Ligand Interaction: From Small Molecules and Peptides to Photoswitchable RNA Binding by Berdnikova, Daria V., Carloni, Paolo, Krauß, Sybille, Rossetti, Giulia

“…Aberrant RNA–protein complexes are formed in a variety of diseases. Identifying the ligands that interfere with their formation is a valuable therapeutic…”
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MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression by Unterbruner, Kristoffer, Matthes, Frank, Schilling, Judith, Nalavade, Rohit, Weber, Stephanie, Winter, Jennifer, Krauß, Sybille

“…The MID1 ubiquitin ligase activates mTOR signaling and regulates mRNA translation. Misregulation of MID1 expression is associated with various diseases…”
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Huntingtin and Its Role in Mechanisms of RNA-Mediated Toxicity by Heinz, Annika, Nabariya, Deepti Kailash, Krauss, Sybille

“…Huntington's disease (HD) is caused by a CAG-repeat expansion mutation in the Huntingtin (HTT) gene. It is characterized by progressive psychiatric and…”
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Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling by Kickstein, Eva, Krauss, Sybille, Thornhill, Paul, Rutschow, Désirée, Zeller, Raphael, Sharkey, John, Williamson, Ritchie, Fuchs, Melanie, Köhler, Andrea, Glossmann, Hartmut, Schneider, Rainer, Sutherland, Calum, Schweiger, Susann, Südhof, Thomas C.

“…Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer's disease (AD) and related…”
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The MID1 Protein: A Promising Therapeutic Target in Huntington’s Disease by Heinz, Annika, Schilling, Judith, van Roon-Mom, Willeke, Krauß, Sybille

“…Huntington’s disease (HD) is caused by an expansion mutation of a CAG repeat in exon 1 of the huntingtin ( HTT ) gene, that encodes an expanded polyglutamine…”
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Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease by Arnoux, Isabelle, Willam, Michael, Griesche, Nadine, Krummeich, Jennifer, Watari, Hirofumi, Offermann, Nina, Weber, Stephanie, Narayan Dey, Partha, Chen, Changwei, Monteiro, Olivia, Buettner, Sven, Meyer, Katharina, Bano, Daniele, Radyushkin, Konstantin, Langston, Rosamund, Lambert, Jeremy J, Wanker, Erich, Methner, Axel, Krauss, Sybille, Schweiger, Susann, Stroh, Albrecht

“…Catching primal functional changes in early, 'very far from disease onset' (VFDO) stages of Huntington's disease is likely to be the key to a successful…”
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Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3 by Evert, Bernd O, Nalavade, Rohit, Jungverdorben, Johannes, Matthes, Frank, Weber, Stephanie, Rajput, Ashish, Bonn, Stefan, Brüstle, Oliver, Peitz, Michael, Krauß, Sybille

“…Molecular chaperones are important regulators of protein folding and proteasomal removal of misfolded proteins. In spinocerebellar ataxia type 3 (SCA3), the…”
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Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties by Nabariya, Deepti Kailash, Heinz, Annika, Derksen, Sabrina, Krauß, Sybille

“…RNA is a vital biomolecule, the function of which is tightly spatiotemporally regulated. RNA organelles are biological structures that either membrane-less or…”
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Editorial: In celebration of women in science: RNA networks and biology by Piccinini, Anna M, Krauß, Sybille

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Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex by Krauß, Sybille, Griesche, Nadine, Jastrzebska, Ewa, Chen, Changwei, Rutschow, Désiree, Achmüller, Clemens, Dorn, Stephanie, Boesch, Sylvia M., Lalowski, Maciej, Wanker, Erich, Schneider, Rainer, Schweiger, Susann

“…Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington’s disease. Here we show that expanded CAG repeats…”
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The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex by Hettich, Moritz M, Matthes, Frank, Ryan, Devon P, Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauβ, Sybille, Ehninger, Dan

“…Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are…”
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A validated antibody panel for the characterization of tau post-translational modifications by Ercan, Ebru, Eid, Sameh, Weber, Christian, Kowalski, Alexandra, Bichmann, Maria, Behrendt, Annika, Matthes, Frank, Krauss, Sybille, Reinhardt, Peter, Fulle, Simone, Ehrnhoefer, Dagmar E

“…Tau is a microtubule-binding protein, which is subject to various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation,…”
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The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu by Schweiger, Susann, Dorn, Stephanie, Fuchs, Melanie, Köhler, Andrea, Matthes, Frank, Müller, Eva-Christina, Wanker, Erich, Schneider, Rainer, Krauß, Sybille

“…SHH (Sonic Hedgehog)-GLI signaling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend…”
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Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3 by Krauss, Sybille, Foerster, John, Schneider, Rainer, Schweiger, Susann

“…Gain-of-function alterations to the sonic hedgehog (SHH) signaling cascade have been found in a wide range of tumors. Three SHH effectors, GLI1, GLI2, and…”
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Control of mTORC1 signaling by the Opitz syndrome protein MID1 by Liu, Enbo, Knutzen, Christine A, Krauss, Sybille, Schweiger, Susann, Chiang, Gary G

“…Mutations in the MID1 gene are causally linked to X-linked Opitz BBB/G syndrome (OS), a congenital disorder that primarily affects the formation of diverse…”
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