Search Results - "Kratochvil, Michael J."

Dynamic light scattering microrheology for soft and living materials by Cai, Pamela C, Krajina, Brad A, Kratochvil, Michael J, Zou, Lei, Zhu, Audrey, Burgener, Elizabeth B, Bollyky, Paul L, Milla, Carlos E, Webber, Matthew J, Spakowitz, Andrew J, Heilshorn, Sarah C

“…We present a method for using dynamic light scattering in the single-scattering limit to measure the viscoelastic moduli of soft materials. This microrheology…”
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Evidence of a preferred kinetic pathway in the carnitine acetyltransferase reaction by Kratochvil, Michael J., Balerud, Nick K., Schindler, Samantha J., Moxley, Michael A.

“…Mammalian carnitine acetyltransferase (CrAT) is a mitochondrial enzyme that catalyzes the reversible transfer of an acetyl group from acetyl-CoA to carnitine…”
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Review: Bioengineering strategies to probe T cell mechanobiology by de la Zerda, Adi, Kratochvil, Michael J., Suhar, Nicholas A., Heilshorn, Sarah C.

“…T cells play a major role in adaptive immune response, and T cell dysfunction can lead to the progression of several diseases that are often associated with…”
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Filamentous Bacteriophages and the Competitive Interaction between Pseudomonas aeruginosa Strains under Antibiotic Treatment: a Modeling Study by Pourtois, Julie D, Kratochvil, Michael J, Chen, Qingquan, Haddock, Naomi L, Burgener, Elizabeth B, De Leo, Giulio A, Bollyky, Paul L

“…Pseudomonas aeruginosa ( ) is a major bacterial pathogen responsible for chronic lung infections in cystic fibrosis patients. Recent work has implicated Pf…”
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Engineered materials for organoid systems by Kratochvil, Michael J., Seymour, Alexis J., Li, Thomas L., Paşca, Sergiu P., Kuo, Calvin J., Heilshorn, Sarah C.

“…Organoids are 3D cell culture systems that mimic some of the structural and functional characteristics of an organ. Organoid cultures provide the opportunity…”
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Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice by Shamskhou, Elya A., Kratochvil, Michael J., Orcholski, Mark E., Nagy, Nadine, Kaber, Gernot, Steen, Emily, Balaji, Swathi, Yuan, Ke, Keswani, Sundeep, Danielson, Ben, Gao, Max, Medina, Carlos, Nathan, Abinaya, Chakraborty, Ananya, Bollyky, Paul L., De Jesus Perez, Vinicio A.

“…Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive lung disorder with limited therapeutic options. While interleukin-10 (IL-10) is a potent…”
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Superhydrophobic Polymer Multilayers that Promote the Extended, Long-Term Release of Embedded Water-Soluble Agents by Manna, Uttam, Kratochvil, Michael J., Lynn, David M.

“…Polymer multilayers that exhibit surface and bulk superhydrophobicity are demonstrated to promote long‐term release of water‐soluble agents (for ca.1 year)…”
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Designer, injectable gels to prevent transplanted Schwann cell loss during spinal cord injury therapy by Marquardt, Laura M, Doulames, Vanessa M, Wang, Alice T, Dubbin, Karen, Suhar, Riley A, Kratochvil, Michael J, Medress, Zachary A, Plant, Giles W, Heilshorn, Sarah C

“…Transplantation of patient-derived Schwann cells is a promising regenerative medicine therapy for spinal cord injuries; however, therapeutic efficacy is…”
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Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice by Nagy, Nadine, Kaber, Gernot, Kratochvil, Michael J., Kuipers, Hedwich F., Ruppert, Shannon M., Yadava, Koshika, Yang, Jason, Heilshorn, Sarah C., Long, S. Alice, Pugliese, Alberto, Bollyky, Paul L.

“…Aims/hypothesis IL-2 injections are a promising therapy for autoimmune type 1 diabetes but the short half-life of this cytokine in vivo limits effective tissue…”
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Hyaluronan content governs tissue stiffness in pancreatic islet inflammation by Nagy, Nadine, de la Zerda, Adi, Kaber, Gernot, Johnson, Pamela Y., Hu, Kenneth H., Kratochvil, Michael J., Yadava, Koshika, Zhao, Wenting, Cui, Yi, Navarro, Guadalupe, Annes, Justin P., Wight, Thomas N., Heilshorn, Sarah C., Bollyky, Paul L., Butte, Manish J.

“…We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in governing the mechanical properties of inflamed tissues. We recently…”
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Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells by Kratochvil, Michael J, Welsh, Michael A, Manna, Uttam, Ortiz, Benjamín J, Blackwell, Helen E, Lynn, David M

“…Surfaces that can both prevent bacterial biofouling and inhibit the expression of virulence phenotypes in surrounding planktonic bacteria are of interest in a…”
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Amine-Reactive Azlactone-Containing Nanofibers for the Immobilization and Patterning of New Functionality on Nanofiber-Based Scaffolds by Kratochvil, Michael J, Carter, Matthew C. D, Lynn, David M

“…We report the design of amine-reactive polymer nanofibers and nonwoven reactive nanofiber mats fabricated by the electrospinning of azlactone-functionalized…”
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Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control by Kratochvil, Michael J, Yang, Tian, Blackwell, Helen E, Lynn, David M

“…We report the fabrication and biological evaluation of nonwoven polymer nanofiber coatings that inhibit quorum sensing (QS) and virulence in the human pathogen…”
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Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus by Kratochvil, Michael J, Tal-Gan, Yftah, Yang, Tian, Blackwell, Helen E, Lynn, David M

“…Materials and coatings that inhibit bacterial colonization are of interest in a broad range of biomedical, environmental, and industrial applications. In view…”
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The lysogenic filamentous Pseudomonas bacteriophage phage Pf slows mucociliary transport by Burgener, Elizabeth B, Cai, Pamela C, Kratochvil, Michael J, Rojas-Hernandez, Laura S, Joo, Nam Soo, Gupta, Aditi, Secor, Patrick R, Heilshorn, Sarah C, Spakowitz, Andrew J, Wine, Jeffrey J, Bollyky, Paul L, Milla, Carlos E

“…is a major pulmonary pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF). The and lysogenic bacteriophage, Pf phage, is abundant…”
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Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding by Chen, Qingquan, Cai, Pam, Chang, Tony Hong Wei, Burgener, Elizabeth, Kratochvil, Michael J, Gupta, Aditi, Hargill, Aviv, Secor, Patrick R, Nielsen, Josefine Eilsø, Barron, Annelise E, Milla, Carlos, Heilshorn, Sarah C, Spakowitz, Andy, Bollyky, Paul L

“…Despite great progress in the field, chronic ( ) infections remain a major cause of mortality in patients with cystic fibrosis (pwCF), necessitating treatment…”
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Good species behaving badly: Non-monophyly of black fly sibling species in the Simulium arcticum complex (Diptera: Simuliidae) by Conflitti, Ida M., Kratochvil, Michael J., Spironello, Michael, Shields, Gerald F., Currie, Douglas C.

“…Mitochondrial based phylogenetic reconstructions often show deviations from species-level monophyly. We used the Simulium arcticum species complex (Diptera:…”
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Rapid assessment of changes in phage bioactivity using dynamic light scattering by Dharmaraj, Tejas, Kratochvil, Michael J, Pourtois, Julie D, Chen, Qingquan, Hajfathalian, Maryam, Hargil, Aviv, Lin, Yung-Hao, Evans, Zoe, Oromí-Bosch, Agnès, Berry, Joel D, McBride, Robert, Haddock, Naomi L, Holman, Derek R, van Belleghem, Jonas D, Chang, Tony H, Barr, Jeremy J, Lavigne, Rob, Heilshorn, Sarah C, Blankenberg, Francis G, Bollyky, Paul L

“…Extensive efforts are underway to develop bacteriophages as therapies against antibiotic-resistant bacteria. However, these efforts are confounded by the…”
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Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus by Broderick, Adam H., Stacy, Danielle M., Tal-Gan, Yftah, Kratochvil, Michael J., Blackwell, Helen E., Lynn, David M.

“…Staphylococcus aureus is a major human pathogen responsible for a variety of life‐threatening infections. The pathogenicity of this organism is attributed to…”
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Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections by Kratochvil, Michael J, Kaber, Gernot, Demirdjian, Sally, Cai, Pamela C, Burgener, Elizabeth B, Nagy, Nadine, Barlow, Graham L, Popescu, Medeea, Nicolls, Mark R, Ozawa, Michael G, Regula, Donald P, Pacheco-Navarro, Ana E, Yang, Samuel, de Jesus Perez, Vinicio A, Karmouty-Quintana, Harry, Peters, Andrew M, Zhao, Bihong, Buja, Maximilian L, Johnson, Pamela Y, Vernon, Robert B, Wight, Thomas N, Milla, Carlos E, Rogers, Angela J, Spakowitz, Andrew J, Heilshorn, Sarah C, Bollyky, Paul L

“…Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly…”
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