Search Results - "Kratchmarov, Radomir"

TCF1 expression marks self-renewing human CD8+ T cells by Kratchmarov, Radomir, Magun, Arthur M., Reiner, Steven L.

“…Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced murine CD8+ T cells that retain potential for lymphoid…”
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Cytoplasmic Form of Carlr lncRNA Facilitates Inflammatory Gene Expression upon NF-κB Activation by Castellanos-Rubio, Ainara, Kratchmarov, Radomir, Sebastian, Maialen, Garcia-Etxebarria, Koldo, Garcia, Liher, Irastorza, Iñaki, Ghosh, Sankar

“…Long noncoding RNAs (lncRNAs) have emerged as critical regulators of inflammation. To further understand the interaction between inflammatory signaling…”
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CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions by Nish, Simone A, Zens, Kyra D, Kratchmarov, Radomir, Lin, Wen-Hsuan W, Adams, William C, Chen, Yen-Hua, Yen, Bonnie, Rothman, Nyanza J, Bhandoola, Avinash, Xue, Hai-Hui, Farber, Donna L, Reiner, Steven L

“…Upon infection, an activated CD4 T cell produces terminally differentiated effector cells and renews itself for continued defense. In this study, we show that…”
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Glycoproteins gE and gI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons by Kratchmarov, Radomir, Kramer, Tal, Greco, Todd M, Taylor, Matthew P, Ch'ng, Toh Hean, Cristea, Ileana M, Enquist, Lynn W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CD8+ T Lymphocyte Self-Renewal during Effector Cell Determination by Lin, Wen-Hsuan W., Nish, Simone A., Yen, Bonnie, Chen, Yen-Hua, Adams, William C., Kratchmarov, Radomir, Rothman, Nyanza J., Bhandoola, Avinash, Xue, Hai-Hui, Reiner, Steven L.

“…Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew, often repeatedly. We now show that silencing expression of the…”
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Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal by Adams, William C., Chen, Yen-Hua, Kratchmarov, Radomir, Yen, Bonnie, Nish, Simone A., Lin, Wen-Hsuan W., Rothman, Nyanza J., Luchsinger, Larry L., Klein, Ulf, Busslinger, Meinrad, Rathmell, Jeffrey C., Snoeck, Hans-Willem, Reiner, Steven L.

“…Regeneration requires related cells to diverge in fate. We show that activated lymphocytes yield sibling cells with unequal elimination of aged mitochondria…”
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Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation by Lin, Wen-Hsuan W., Adams, William C., Nish, Simone A., Chen, Yen-Hua, Yen, Bonnie, Rothman, Nyanza J., Kratchmarov, Radomir, Okada, Takaharu, Klein, Ulf, Reiner, Steven L.

“…Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of…”
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Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway by Chen, Yen-Hua, Kratchmarov, Radomir, Lin, Wen-Hsuan W., Rothman, Nyanza J., Yen, Bonnie, Adams, William C., Nish, Simone A., Rathmell, Jeffrey C., Reiner, Steven L.

“…Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes…”
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Role of Us9 phosphorylation in axonal sorting and anterograde transport of pseudorabies virus by Kratchmarov, Radomir, Taylor, Matthew P, Enquist, Lynn W

“…Alphaherpes viruses, such as pseudorabies virus (PRV), undergo anterograde transport in neuronal axons to facilitate anterograde spread within hosts. Axonal…”
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Identification of a human multipotent TH2 progenitor

“…In this study, we use a transcriptomic approach as a starting point to explore the heterogeneity of human GATA3 -expressing lymphocytes across different…”
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A long noncoding RNA associated with susceptibility to celiac disease by Castellanos-Rubio, Ainara, Fernandez-Jimenez, Nora, Kratchmarov, Radomir, Luo, Xiaobing, Bhagat, Govind, Green, Peter H. R., Schneider, Robert, Kiledjian, Megerditch, Bilbao, Jose Ramon, Ghosh, Sankar

“…Recent studies have implicated long noncoding RNAs (IncRNAs) as regulators of many important biological processes. Here we report on the identification and…”
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Promoting TCF1+ T-cell self-renewal to improve PD-1 blockade by Wang, Peter H., Washburn, Robert, Maniar, Rohan, Mu, Michael, Ringham, Olivia, Kratchmarov, Radomir, Henick, Brian S., Reiner, Steven L.

“…Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable anti-tumor responses. Self-renewing (TCF1 + ) 3 CD8…”
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Cutting Edge: Promoting T Cell Factor 1 + T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade by Wang, Peter H, Washburn, Robert, Maniar, Rohan, Mu, Michael, Ringham, Olivia, Kratchmarov, Radomir, Henick, Brian S, Reiner, Steven L

“…Immune checkpoint blockade is limited by resistance to treatment, with many patients not achieving durable antitumor responses. Self-renewing (T cell factor 1…”
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Metabolic control of cell fate bifurcations in a hematopoietic progenitor population by Kratchmarov, Radomir, Viragova, Sara, Kim, Min Jung, Rothman, Nyanza J, Liu, Kang, Reizis, Boris, Reiner, Steven L

“…Growth signals drive hematopoietic progenitor cells to proliferate and branch into divergent cell fates, but how unequal outcomes arise from a common…”
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TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases by Kratchmarov, Radomir, Djeddi, Sarah, Dunlap, Garrett, He, Wenqin, Jia, Xiaojiong, Burk, Caitlin M., Ryan, Tessa, McGill, Alanna, Allegretti, Jessica R., Kataru, Raghu P., Mehrara, Babak J., Taylor, Erin M., Agarwal, Shailesh, Bhattacharyya, Neil, Bergmark, Regan W., Maxfield, Alice Z., Lee, Stella, Roditi, Rachel, Dwyer, Daniel F., Boyce, Joshua A., Buchheit, Kathleen M., Laidlaw, Tanya M., Shreffler, Wayne G., Rao, Deepak A., Gutierrez-Arcelus, Maria, Brennan, Patrick J.

“…Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion, limiting adaptive immunity. In contrast, aberrant, sustained T cell…”
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Metabolism Regulates Cell Fate in Lymphocytes and Progenitor Cells by Kratchmarov, Radomir

“…Self-renewal mediates homeostasis across mammalian organ systems as the cellular components of mature tissues are continually replaced in the face of wear and…”
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Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy by Maniar, Rohan, Wang, Peter H, Washburn, Robert S, Kratchmarov, Radomir, Coley, Shana M, Saqi, Anjali, Pan, Samuel S, Hu, Jianhua, Shu, Catherine A, Rizvi, Naiyer A, Henick, Brian S, Reiner, Steven L

“…Treatment with immune checkpoint blockade (ICB) often fails to elicit durable antitumor immunity. Recent studies suggest that ICB does not restore potency to…”
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Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities by Kumar, Brahma V, Kratchmarov, Radomir, Miron, Michelle, Carpenter, Dustin J, Senda, Takashi, Lerner, Harvey, Friedman, Amy, Reiner, Steven L, Farber, Donna L

“…Tissue-resident memory T cells (TRMs) accelerate pathogen clearance through rapid and enhanced functional responses in situ. TRMs are prevalent in diverse…”
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Irreversible effector CD8+ T cell differentiation is linked to asymmetric, intra-divisional TCF1 silencing by Lin, Wen-Hsuan Wendy, Yen, Bonnie, Nish, Simone A, Kratchmarov, Radomir, Bhandoola, Avinash, Xue, Hai-Hui (Howard), Reiner, Steven L

“…Abstract During specific immune responses, naive T cells give rise to terminally differentiated effector T cells and pluripotent, self-renewing central memory…”
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Mast cells control lung type 2 inflammation via prostaglandin E 2 -driven soluble ST2 by Alhallak, Kinan, Nagai, Jun, Zaleski, Kendall, Marshall, Sofia, Salloum, Tamara, Derakhshan, Tahereh, Hayashi, Hiroaki, Feng, Chunli, Kratchmarov, Radomir, Lai, Juying, Kuchibhotla, Virinchi, Nishida, Airi, Balestrieri, Barbara, Laidlaw, Tanya, Dwyer, Daniel F, Boyce, Joshua A

“…Severe asthma and sinus disease are consequences of type 2 inflammation (T2I), mediated by interleukin (IL)-33 signaling through its membrane-bound receptor,…”
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