Clinical and immunological characteristics of rubella in western Siberia

Evaluations of immune system of 155 patients with rubella and 90 contacts with patients were examined. Detection of viral genetic material in blood, urine, and nasopharyngeal swabs has been performed using RT-PCR method. Clinical diagnosis has been confirmed by RT-PCR in 114 (73.5%) patients. Change...

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Bibliographic Details
Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 2; p. 44
Main Authors:	Malkova, E M, Petrova, I D, Smerdova, M A, Obert, A S, Pomogaeva, A P, Minakova, Iu V, Iur'ev, S Iu, Krasnov, A V, Khokhlova, Z A, Golubina, E A, Zinov'eva, L I, Krasman, O M, Ustinova, E N, Tiunnikov, G I, Iashina, L N, Netesov, S V, Petrov, V S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-2007
Subjects:	Adolescent Adult Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Affinity Carrier State - diagnosis Carrier State - immunology Child Child, Preschool Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Infant Male Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - analysis Rubella - diagnosis Rubella - immunology Rubella - virology Rubella virus - genetics Rubella virus - immunology Rubella virus - isolation & purification Siberia Siberia
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Summary:	Evaluations of immune system of 155 patients with rubella and 90 contacts with patients were examined. Detection of viral genetic material in blood, urine, and nasopharyngeal swabs has been performed using RT-PCR method. Clinical diagnosis has been confirmed by RT-PCR in 114 (73.5%) patients. Changes of laboratory tests for rubella without clinical signs of the infection were observed in 20% of contacts. Complex ELISA- and PCR-assisted examination of patients can help to determine the stage of disease and characteristics of immune response. For differential diagnostic of rubella and other infectious diseases with exanthema it is rational to perform complex examination of patients using immunologic and molecular biologic methods.
ISSN:	0372-9311