Radiation dose–response curves: cell repair mechanisms vs. ion track overlapping

Radiation dose–response curves: cell repair mechanisms vs. ion track overlapping

Chromosome aberrations in human lymphocytes exposed to different doses of particle radiation: 150 MeV and spread out Bragg peak proton beams, 22 MeV/u boron beam and 199 V/u carbon beam were studied. For comparison, an experiment with 60 Co γ -rays was also performed. We investigated distributions o...

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Bibliographic Details
Published in:The European physical journal. D, Atomic, molecular, and optical physics Vol. 71; no. 12; pp. 1 - 8
Main Authors: Kowalska, Agata, Czerski, Konrad, Nasonova, Elena, Kutsalo, Polina, Krasavin, Eugen
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2017
Springer Nature B.V
Subjects:
Aberration
Applications of Nonlinear Dynamics and Chaos Theory
Atomic
Biological effects
Boron
Bragg curve
Curvature
Lymphocytes
Molecular
Optical and Plasma Physics
Particle beams
Physical Chemistry
Physics
Physics and Astronomy
Proton beams
Quantum Information Technology
Quantum Physics
Radiation dosage
Regular Article
Repair
Spectroscopy/Spectrometry
Spintronics
Topical Issue: Dynamics of Systems at the Nanoscale
Online Access:Get full text
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Summary:Chromosome aberrations in human lymphocytes exposed to different doses of particle radiation: 150 MeV and spread out Bragg peak proton beams, 22 MeV/u boron beam and 199 V/u carbon beam were studied. For comparison, an experiment with 60 Co γ -rays was also performed. We investigated distributions of aberration frequency and the shape of dose–response curves for the total aberration yield as well as for exchange and non-exchange aberrations, separately. Applying the linear-quadratic model, we could derive a relation between the fitted parameters and the ion track radius which could explain experimentally observed curvature of the dose–response curves. The results compared with physical expectations clearly show that the biological effects of cell repair are much more important than the ion track overlapping. Graphical abstract
ISSN:1434-6060
1434-6079
DOI:10.1140/epjd/e2017-80013-2