Search Results - "Krapf, Irina P."

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies by Bowers, Peter M, Horlick, Robert A, Neben, Tamlyn Y, Toobian, Rachelle M, Tomlinson, Geoffrey L, Dalton, Jennifer L, Jones, Heather A, Chen, Andy, Altobell, Laurence III, Zhang, Xue, Macomber, John L, Krapf, Irina P, Wu, Betty F, McConnell, Audrey, Chau, Betty, Holland, Trevin, Berkebile, Ashley D, Neben, Steven S, Boyle, William J, King, David J

“…A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling…”
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Mammalian cell display for the discovery and optimization of antibody therapeutics by Bowers, Peter M., Horlick, Robert A., Kehry, Marilyn R., Neben, Tamlyn Y., Tomlinson, Geoffery L., Altobell, Larry, Zhang, Xue, Macomber, John L., Krapf, Irina P., Wu, Betty F., McConnell, Audrey D., Chau, Betty, Berkebile, Ashley D., Hare, Eric, Verdino, Petra, King, David J.

“…Recent advances are described for the isolation and affinity maturation of antibodies that couple in vitro somatic hypermutation (SHM) with mammalian cell…”
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Simultaneous Surface Display and Secretion of Proteins from Mammalian Cells Facilitate Efficient in Vitro Selection and Maturation of Antibodies by Horlick, Robert A., Macomber, John L., Bowers, Peter M., Neben, Tamlyn Y., Tomlinson, Geoffery L., Krapf, Irina P., Dalton, Jennifer L., Verdino, Petra, King, David J.

“…A mammalian expression system has been developed that permits simultaneous cell surface display and secretion of the same protein through alternate splicing of…”
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An integrated approach to extreme thermostabilization and affinity maturation of an antibody by McConnell, Audrey D., Spasojevich, Vladimir, Macomber, John L., Krapf, Irina P., Chen, Andy, Sheffer, Joseph C., Berkebile, Ashley, Horlick, Robert A., Neben, Steven, King, David J., Bowers, Peter M.

“…Antibodies are important tools for a broad range of applications due to their high specificity and ability to recognize virtually any target molecule. However,…”
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