Search Results - "Kranz, Mathias"

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors by Gnad, Thorsten, Scheibler, Saskia, von Kügelgen, Ivar, Scheele, Camilla, Kilić, Ana, Glöde, Anja, Hoffmann, Linda S., Reverte-Salisa, Laia, Horn, Philipp, Mutlu, Samet, El-Tayeb, Ali, Kranz, Mathias, Deuther-Conrad, Winnie, Brust, Peter, Lidell, Martin E., Betz, Matthias J., Enerbäck, Sven, Schrader, Jürgen, Yegutkin, Gennady G., Müller, Christa E., Pfeifer, Alexander

“…Cold exposure activates brown adipose tissue (BAT) through the sympathetic nervous system, and previous studies have reported inhibitory effects of the…”
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Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity by Gnad, Thorsten, Navarro, Gemma, Lahesmaa, Minna, Reverte-Salisa, Laia, Copperi, Francesca, Cordomi, Arnau, Naumann, Jennifer, Hochhäuser, Aileen, Haufs-Brusberg, Saskia, Wenzel, Daniela, Suhr, Frank, Jespersen, Naja Zenius, Scheele, Camilla, Tsvilovskyy, Volodymyr, Brinkmann, Christian, Rittweger, Joern, Dani, Christian, Kranz, Mathias, Deuther-Conrad, Winnie, Eltzschig, Holger K., Niemi, Tarja, Taittonen, Markku, Brust, Peter, Nuutila, Pirjo, Pardo, Leonardo, Fleischmann, Bernd K., Blüher, Matthias, Franco, Rafael, Bloch, Wilhelm, Virtanen, Kirsi A., Pfeifer, Alexander

“…The combination of aging populations with the obesity pandemic results in an alarming rise in non-communicable diseases. Here, we show that the enigmatic…”
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Weakly supervised semantic segmentation for MRI: exploring the advantages and disadvantages of class activation maps for biological image segmentation with soft boundaries by Syed, Shaheen, Anderssen, Kathryn E., Stormo, Svein Kristian, Kranz, Mathias

“…Fully supervised semantic segmentation models require pixel-level annotations that are costly to obtain. As a remedy, weakly supervised semantic segmentation…”
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The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines by von Hofsten, Susannah, Paulsen, Marianne Hagensen, Magnussen, Synnøve Norvoll, Ausbacher, Dominik, Kranz, Mathias, Bayer, Annette, Strøm, Morten B., Berge, Gerd

“…Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce…”
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Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor by Moldovan, Rareş-Petru, Teodoro, Rodrigo, Gao, Yongjun, Deuther-Conrad, Winnie, Kranz, Mathias, Wang, Yuchuan, Kuwabara, Hiroto, Nakano, Masayoshi, Valentine, Heather, Fischer, Steffen, Pomper, Martin G, Wong, Dean F, Dannals, Robert F, Brust, Peter, Horti, Andrew G

“…Cannabinoid receptors type 2 (CB2) represent a target with increasing importance for neuroimaging due to its upregulation under various pathological…”
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PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy by Schröder, Susann, Lai, Thu Hang, Toussaint, Magali, Kranz, Mathias, Chovsepian, Alexandra, Shang, Qi, Dukić-Stefanović, Sladjana, Deuther-Conrad, Winnie, Teodoro, Rodrigo, Wenzel, Barbara, Moldovan, Rareş-Petru, Pan-Montojo, Francisco, Brust, Peter

“…The adenosine A2A receptor (A2AR) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased…”
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4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment by Sellæg, Kjersti, Schwienbacher, Ruth, Kranz, Mathias, Aamodt, Anna Engan, Wirsing, Anna M, Berge, Gerd, Hadler-Olsen, Elin, Magnussen, Synnøve Norvoll

“…Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph…”
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Synthesis and Biological Evaluation of a Novel 18F-Labeled Radiotracer for PET Imaging of the Adenosine A2A Receptor by Lai, Thu Hang, Toussaint, Magali, Teodoro, Rodrigo, Dukić-Stefanović, Sladjana, Kranz, Mathias, Deuther-Conrad, Winnie, Moldovan, Rareş-Petru, Brust, Peter

“…The adenosine A2A receptor (A2AR) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive…”
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Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using ( S )-(-)-[ 18 F]Fluspidine in Glioblastoma by Toussaint, Magali, Deuther-Conrad, Winnie, Kranz, Mathias, Fischer, Steffen, Ludwig, Friedrich-Alexander, Juratli, Tareq A, Patt, Marianne, Wünsch, Bernhard, Schackert, Gabriele, Sabri, Osama, Brust, Peter

“…Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to…”
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Development of 18F-Labeled Radiotracers for PET Imaging of the Adenosine A2A Receptor: Synthesis, Radiolabeling and Preliminary Biological Evaluation by Lai, Thu Hang, Schröder, Susann, Toussaint, Magali, Dukić-Stefanović, Sladjana, Kranz, Mathias, Ludwig, Friedrich-Alexander, Fischer, Steffen, Steinbach, Jörg, Deuther-Conrad, Winnie, Brust, Peter, Moldovan, Rareş-Petru

“…The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission…”
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Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography by Ritawidya, Rien, Wenzel, Barbara, Teodoro, Rodrigo, Toussaint, Magali, Kranz, Mathias, Deuther-Conrad, Winnie, Dukic-Stefanovic, Sladjana, Ludwig, Friedrich-Alexander, Scheunemann, Matthias, Brust, Peter

“…A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A PDE2A) via positron emission tomography (PET) would be helpful for research on…”
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Preclinical Evaluation of [18F]FACH in Healthy Mice and Piglets: An 18F-Labeled Ligand for Imaging of Monocarboxylate Transporters with PET by Gündel, Daniel, Sadeghzadeh, Masoud, Deuther-Conrad, Winnie, Wenzel, Barbara, Cumming, Paul, Toussaint, Magali, Ludwig, Friedrich-Alexander, Moldovan, Rareş-Petru, Kranz, Mathias, Teodoro, Rodrigo, Sattler, Bernhard, Sabri, Osama, Brust, Peter

“…The expression of monocarboxylate transporters (MCTs) is linked to pathophysiological changes in diseases, including cancer, such that MCTs could potentially…”
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Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [(18)F]Fluspidine-A New Tracer in Clinical Translation for Imaging of σ₁ Receptors by Kranz, Mathias, Sattler, Bernhard, Wüst, Nathanael, Deuther-Conrad, Winnie, Patt, Marianne, Meyer, Philipp M, Fischer, Steffen, Donat, Cornelius K, Wünsch, Bernhard, Hesse, Swen, Steinbach, Jörg, Brust, Peter, Sabri, Osama

“…The enantiomers of [(18)F]fluspidine, recently developed for imaging of σ₁ receptors, possess distinct pharmacokinetics facilitating their use in different…”
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Gender differences in cerebral metabolism for color processing in mice: A PET/MRI Study by Njemanze, Philip C, Kranz, Mathias, Amend, Mario, Hauser, Jens, Wehrl, Hans, Brust, Peter

“…Color processing is a central component of mammalian vision. Gender-related differences of color processing revealed by non-invasive functional transcranial…”
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Characterization of vasskveite (water halibut) syndrome for automated detection by Ortega, Samuel, Ofstad, Ragni, Syed, Shaheen, Kranz, Mathias, Heia, Karsten, Anderssen, Kathryn E.

“…•Spectroscopy and histology was used to evaluate vasskveite syndrome.•Hyperspectral imaging evaluated fat and water content in healthy and afflicted…”
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Preclinical Incorporation Dosimetry of [18F]FACH—A Novel 18F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET by Sattler, Bernhard, Kranz, Mathias, Wenzel, Barbara, Jain, Nalin T., Moldovan, Rareş-Petru, Toussaint, Magali, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Teodoro, Rodrigo, Sattler, Tatjana, Sadeghzadeh, Masoud, Sabri, Osama, Brust, Peter

“…Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition…”
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Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma by Suwattananuruk, Piyapan, Yaset, Sukanya, Chotipanich, Chanisa, Moldes-Anaya, Angel, Sundset, Rune, Berzaghi, Rodrigo, Figenschau, Stine, Claes, Sandra, Schols, Dominique, Rojsitthisak, Pornchai, Kranz, Mathias, Vajragupta, Opa

“…Background This study aimed to develop a novel positron emission tomography (PET) tracer, [ 68 Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the…”
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Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels by Weiner, Juliane, Roth, Lisa, Kranz, Mathias, Brust, Peter, Boelen, Anita, Klöting, Nora, Heiker, John T., Blüher, Matthias, Tönjes, Anke, Pfluger, Paul T., Stumvoll, Michael, Mittag, Jens, Krause, Kerstin

“…Thyroid hormones (TH) are essential for the homeostatic control of energy metabolism and the regulation of body temperature. The hypothalamic–pituitary–thyroid…”
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Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease by Schaffernicht, Gabriela, Shang, Qi, Stievenard, Alicia, Bötzel, Kai, Dening, Yanina, Kempe, Romy, Toussaint, Magali, Gündel, Daniel, Kranz, Mathias, Reichmann, Heinz, Vanbesien-Mailliot, Christel, Brust, Peter, Dieterich, Marianne, Funk, Richard H W, Ravens, Ursula, Pan-Montojo, Francisco

“…Parkinson's disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear…”
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Bridging from Brain to Tumor Imaging: (S)-(-)- and (R)-(+)-[ 18 F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice by Kranz, Mathias, Bergmann, Ralf, Kniess, Torsten, Belter, Birgit, Neuber, Christin, Cai, Zhengxin, Deng, Gang, Fischer, Steffen, Zhou, Jiangbing, Huang, Yiyun, Brust, Peter, Deuther-Conrad, Winnie, Pietzsch, Jens

“…Sigma-1 receptors (Sig1R) are highly expressed in various human cancer cells and hence imaging of this target with positron emission tomography (PET) can…”
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