Search Results - "Krantz, Bryan"

Anthrax Toxin: Model System for Studying Protein Translocation by Krantz, Bryan A.

“…[Display omitted] •Anthrax toxin translocates cytotoxic enzyme factors across membranes into host cells.•Protective antigen moiety forms a large oligomeric…”
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Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis by Jorgensen, Ine, Zhang, Yue, Krantz, Bryan A, Miao, Edward A

“…Inflammasomes activate caspase-1 in response to cytosolic contamination or perturbation. This inflammatory caspase triggers the opening of the GSDMD pore in…”
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Peptide- and proton-driven allosteric clamps catalyze anthrax toxin translocation across membranes by Das, Debasis, Krantz, Bryan A.

“…Anthrax toxin is an intracellularly acting toxin in which sufficient information is available regarding the structure of its transmembrane channel, allowing…”
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Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin by Abrami, Laurence, Brandi, Lucia, Moayeri, Mahtab, Brown, Michael J., Krantz, Bryan A., Leppla, Stephen H., van der Goot, F. Gisou

“…Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly…”
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Rapid induction of inflammatory lipid mediators by the inflammasome in vivo by von Moltke, Jakob, Trinidad, Norver J., Moayeri, Mahtab, Kintzer, Alexander F., Wang, Samantha B., van Rooijen, Nico, Brown, Charles R., Krantz, Bryan A., Leppla, Stephen H., Gronert, Karsten, Vance, Russell E.

“…Induction of an eicosanoid storm is shown to be an unexpected consequence of inflammasome activation in peritoneal macrophages, leading to vascular leakage and…”
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REPLY TO YAMINI AND NESTOROVICH: Alternate clamped states of the anthrax toxin protective antigen channel by Krantz, Bryan A.

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Secondary Structure Preferences of the Anthrax Toxin Protective Antigen Translocase by Das, Debasis, Krantz, Bryan A.

“…In order for many proteins to move across hydrophobic membrane bilayers, they must be unfolded and translocated by a membrane-embedded channel. These…”
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Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen by Biondi, Elisa, Lane, Joshua D, Das, Debasis, Dasgupta, Saurja, Piccirilli, Joseph A, Hoshika, Shuichi, Bradley, Kevin M, Krantz, Bryan A, Benner, Steven A

“…Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment…”
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Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors by Krantz, Bryan A

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Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors by Hardenbrook, Nathan J., Liu, Shiheng, Zhou, Kang, Ghosal, Koyel, Zhou, Z. Hong, Krantz, Bryan A.

“…Following assembly, the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) or edema…”
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Atomic Structures of Anthrax Prechannel Bound with Full-Length Lethal and Edema Factors by Zhou, Kang, Liu, Shiheng, Hardenbrook, Nathan J., Cui, Yanxiang, Krantz, Bryan A., Zhou, Z. Hong

“…Pathogenesis of anthrax disease involves two cytotoxic enzymes—edema factor (EF) and lethal factor (LF)—which are individually recruited by the protective…”
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The unfolding story of anthrax toxin translocation by Thoren, Katie L., Krantz, Bryan A.

“…Summary The essential cellular functions of secretion and protein degradation require a molecular machine to unfold and translocate proteins either across a…”
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Ratcheting up protein translocation with anthrax toxin by Feld, Geoffrey K., Brown, Michael J., Krantz, Bryan A.

“…Energy‐consuming nanomachines catalyze the directed movement of biopolymers in the cell. They are found both dissolved in the aqueous cytosol as well as…”
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The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes by Kintzer, Alexander F., Thoren, Katie L., Sterling, Harry J., Dong, Ken C., Feld, Geoffrey K., Tang, Iok I., Zhang, Teri T., Williams, Evan R., Berger, James M., Krantz, Bryan A.

“…The assembly of bacterial toxins and virulence factors is critical to their function, but the regulation of assembly during infection has not been studied. We…”
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Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers by Tang, Iok I, Thoren, Katie L, Feld, Geoffrey K, Greenberg, Shoshana G, Krantz, Bryan A, Williams, Evan R, Sterling, Harry J, Kintzer, Alexander F

“…The anthrax lethal toxin protein transporter consists of protective antigen (PA) and lethal factor (LF), with LF unfolding for translocation into the host…”
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Protein Translocation through the Anthrax Toxin Transmembrane Pore is Driven by a Proton Gradient by Krantz, Bryan A., Finkelstein, Alan, Collier, R. John

“…Protective antigen (PA) from anthrax toxin assembles into a homoheptamer on cell surfaces and forms complexes with the enzymatic components: lethal factor (LF)…”
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Role of the α Clamp in the Protein Translocation Mechanism of Anthrax Toxin by Brown, Michael J., Thoren, Katie L., Krantz, Bryan A.

“…Membrane-embedded molecular machines are utilized to move water-soluble proteins across these barriers. Anthrax toxin forms one such machine through the…”
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Peptide Probes Reveal a Hydrophobic Steric Ratchet in the Anthrax Toxin Protective Antigen Translocase by Colby, Jennifer M., Krantz, Bryan A.

“…Anthrax toxin is a tripartite virulence factor produced by Bacillus anthracis during infection. Under acidic endosomal pH conditions, the toxin's protective…”
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Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel by Ghosal, Koyel, Colby, Jennifer M., Das, Debasis, Joy, Stephen T., Arora, Paramjit S., Krantz, Bryan A.

“…Anthrax toxin is an intracellularly acting toxin where sufficient detail is known about the structure of its channel, allowing for molecular investigations of…”
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Supercharging Protein Complexes from Aqueous Solution Disrupts their Native Conformations by Sterling, Harry J., Kintzer, Alexander F., Feld, Geoffrey K., Cassou, Catherine A., Krantz, Bryan A., Williams, Evan R.

“…The effects of aqueous solution supercharging on the solution- and gas-phase structures of two protein complexes were investigated using traveling-wave ion…”
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