Search Results - "Kranias, G"

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome by Kranias, Evangelia G, Hajjar, Roger J

“…Heart disease remains the leading cause of death and disability in the Western world. Current therapies aim at treating the symptoms rather than the…”
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Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend by Haghighi, Kobra, Bidwell, Philip, Kranias, Evangelia G

“…Abstract Depressed sarcoplasmic reticulum (SR) calcium cycling, reflecting impaired SR Ca-transport and Ca-release, is a key and universal characteristic of…”
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Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2 by Zhang, Xiaowei, Wang, Xiaohong, Zhu, Hongyan, Kranias, Evangelia G, Tang, Yaoliang, Peng, Tianqing, Chang, Jiang, Fan, Guo-Chang

“…Heat shock proteins (Hsps) are well appreciated as intrinsic protectors of cardiomyocytes against numerous stresses. Recent studies have indicated that Hsp20…”
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Phospholamban: a crucial regulator of cardiac contractility by MacLennan, David H, Kranias, Evangelia G

“…Heart failure is a major cause of death and disability. Impairments in blood circulation that accompany heart failure can be traced, in part, to alterations in…”
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Leducq Transatlantic Network of Excellence to Cure Phospholamban-Induced Cardiomyopathy (CURE-PLaN) by Doevendans, Pieter A, Glijnis, Pieter C, Kranias, Evangelia G

“…The deletion of Arginine 14 of the phosholamban gene (PLN p.R14del) is associated with the pathogenesis of an inherited form of cardiomyopathy with prominent…”
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The role of CaMKII regulation of phospholamban activity in heart disease by Mattiazzi, Alicia, Kranias, Evangelia G

“…Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca(2) (+)-ATPase (SERCA2a) activity and…”
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Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis by Vafiadaki, Elizabeth, Haghighi, Kobra, Arvanitis, Demetrios A., Kranias, Evangelia G., Sanoudou, Despina

“…Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility…”
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Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure by Fan, Guo-Chang, Kranias, Evangelia G

“…Abstract Hsp20, referred to as HspB6, is constitutively expressed in various tissues. Specifically, HspB6 is most highly expressed in different types of muscle…”
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HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart by Lam, Chi Keung, Zhao, Wen, Liu, Guan-Sheng, Cai, Wen-Feng, Gardner, George, Adly, George, Kranias, Evangelia G.

“…The major underpinning of massive cell death associated with myocardial infarction involves opening of the mitochondrial permeability transition pore (mPTP),…”
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Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle by Goonasekera, Sanjeewa A, Lam, Chi K, Millay, Douglas P, Sargent, Michelle A, Hajjar, Roger J, Kranias, Evangelia G, Molkentin, Jeffery D

“…Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders characterized by progressive muscle wasting and often premature death. The primary…”
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A novel role for phospholamban in the thalamic reticular nucleus by Klocke, Benjamin, Britzolaki, Aikaterini, Saurine, Joseph, Ott, Hayden, Krone, Kylie, Bahamonde, Kiara, Thelen, Connor, Tzimas, Christos, Sanoudou, Despina, Kranias, Evangelia G., Pitychoutis, Pothitos M.

“…The thalamic reticular nucleus (TRN) is a brain region that influences vital neurobehavioral processes, including executive functioning and the generation of…”
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Myofilament Alterations Associated with Human R14del-Phospholamban Cardiomyopathy by Kumar, Mohit, Haghighi, Kobra, Koch, Sheryl, Rubinstein, Jack, Stillitano, Francesca, Hajjar, Roger J, Kranias, Evangelia G, Sadayappan, Sakthivel

“…Phospholamban ( ) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of…”
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The Cardioprotective PKA-Mediated Hsp20 Phosphorylation Modulates Protein Associations Regulating Cytoskeletal Dynamics by Vafiadaki, Elizabeth, Arvanitis, Demetrios A, Eliopoulos, Aristides G, Kranias, Evangelia G, Sanoudou, Despina

“…The cytoskeleton has a primary role in cardiomyocyte function, including the response to mechanical stimuli and injury. The small heat shock protein 20 (Hsp20)…”
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Hsp20‐Engineered Mesenchymal Stem Cells Are Resistant to Oxidative Stress via Enhanced Activation of Akt and Increased Secretion of Growth Factors by Wang, Xiaohong, Zhao, Tiemin, Huang, Wei, Wang, Tao, Qian, Jiang, Xu, Meifeng, Kranias, Evangelia G., Wang, Yigang, Fan, Guo‐Chang

“…Although heat‐shock preconditioning has been shown to promote cell survival under oxidative stress, the nature of heat‐shock response from different cells is…”
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Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban by Schmitt, Joachim P., Kamisago, Mitsuhiro, Asahi, Michio, Li, Guo Hua, Ahmad, Ferhaan, Mende, Ulrike, Kranias, Evangelia G., MacLennan, David H., Seidman, J. G., Seidman, Christine E.

“…Molecular etiologies of heart failure, an emerging cardiovascular epidemic affecting 4.7 million Americans and costing 17.8 billion health-care dollars…”
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Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy by Onusko, Evan, McDermott, Michael R, Robbins, Nathan, Liu, Guansheng, Kranias, Evangelia G, Rubinstein, Jack, Koch, Sheryl E

“…Probenecid has been used for decades in the treatment of gout but recently has also been found to improve outcomes in patients with heart failure via…”
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Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology by Nicolaou, Persoulla, Hajjar, Roger J, Kranias, Evangelia G

“…Abstract The type 1 protein phosphatase (PP1) is a critical negative regulator of Ca2+ cycling and contractility in the cardiomyocyte. In particular, it…”
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CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury by Vila-Petroff, Martin, Salas, Margarita A, Said, Matilde, Valverde, Carlos A, Sapia, Luciana, Portiansky, Enrique, Hajjar, Roger J, Kranias, Evangelia G, Mundiña-Weilenmann, Cecilia, Mattiazzi, Alicia

“…Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the regulation of cardiac excitation-contraction coupling (ECC) as well as in…”
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Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia by Pollak, Adam J., Haghighi, Kobra, Kunduri, Swati, Arvanitis, Demetrios A., Bidwell, Philip A., Liu, Guan-Sheng, Singh, Vivek P., Gonzalez, David J., Sanoudou, Despina, Wiley, Sandra E., Dixon, Jack E., Kranias, Evangelia G.

“…Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially…”
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A Mutation in the Human Phospholamban Gene, Deleting Arginine 14, Results in Lethal, Hereditary Cardiomyopathy by Haghighi, Kobra, Kolokathis, Fotis, Gramolini, Anthony O., Waggoner, Jason R., Pater, Luke, Lynch, Roy A., Fan, Guo-Chang, Tsiapras, Dimitris, Parekh, Rohan R., Dorn, Gerald W., MacLennan, David H., Kremastinos, Dimitrios Th, Kranias, Evangelia G.

“…The sarcoplasmic reticulum Ca²⁺-cycling proteins are key regulators of cardiac contractility, and alterations in sarcoplasmic reticulum Ca²⁺-cycling properties…”
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