Search Results - "Kraner, S D"

Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation by Blalock, E M, Chen, K-C, Stromberg, A J, Norris, C M, Kadish, I, Kraner, S D, Porter, N M, Landfield, P W

“…During normal brain aging, numerous alterations develop in the physiology, biochemistry and structure of neurons and glia. Aging changes occur in most brain…”
Get full text

Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents by Frazier, H. N., Anderson, K. L., Maimaiti, S., Ghoweri, A. O., Kraner, S. D., Popa, G. J., Hampton, K. K., Mendenhall, M. D., Norris, C. M., Craven, R. J., Thibault, O.

“…Memory and cognitive decline are the product of numerous physiological changes within the aging brain. Multiple theories have focused on the oxidative,…”
Get full text

Loss of electrical excitability in an animal model of acute quadriplegic myopathy by Rich, M M, Pinter, M J, Kraner, S D, Barchi, R L

“…In rats treated with high-dose corticosteroids, skeletal muscle that is denervated in vivo (steroid-denervated [S-D]) develops electrical inexcitability…”
Get more information

Silencing the type II sodium channel gene: a model for neural-specific gene regulation by Kraner, S D, Chong, J A, Tsay, H J, Mandel, G

“…Neural-specific expression of a sodium channel mini-gene has been shown to be mediated by a 28 bp silencer element, RE1, located in the 5' flanking region of…”
Get more information

PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types by Mishra, A, Ormerod, A K, Cibull, M L, Spear, B T, Kraner, S D, Kaetzel, D M

“…Development of antineoplastic gene therapies is impaired by a paucity of transcription control elements with efficient, cancer cell-specific activity. We…”
Get full text

Neuron-specific expression of the rat brain type II sodium channel gene is directed by upstream regulatory elements by Maue, R A, Kraner, S D, Goodman, R H, Mandel, G

“…Genetic elements involved in cell-specific expression of the type II sodium channel gene were revealed using transient expression assays. A chimeric reporter…”
Get more information

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons by Chong, Jayhong A, Tapia-Ramirez, José, Kim, Sandra, Toledo-Aral, Juan J, Zheng, Yingcong, Boutros, Michael C, Altshuller, Yelena M, Frohman, Michael A, Kraner, Susan D, Mandel, Gail

“…Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in nonneuronal cells. We have cloned cDNA…”
Get full text

Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes by Kraner, S D, Tanaka, J C, Barchi, R L

“…The voltage-sensitive sodium channel has been purified from rabbit T-tubular membranes and reconstituted into defined phospholipid vesicles. Membranes enriched…”
Get full text

Analysis of Local Structure in the D2/S1–S2 Region of the Rat Skeletal Muscle Type 1 Sodium Channel Using Insertional Mutagenesis by Kraner, Susan D., Filatov, Gregory N., Sun, Weijing, Bannerman, Peter, Lindstrom, Jon, Barchi, Robert L.

“…: A reporter epitope was inserted at 11 positions in a region encompassing proposed transmembrane segments S1 and S2 in the second repeat domain (D2) of the…”
Get full text

Altered Gene Expression in Steroid-Treated Denervated Muscle by Rich, Mark M., Kraner, Susan D., Barchi, Robert L.

“…In rats treated with high-dose corticosteroids, skeletal muscle that is denervated in vivo (steroid-denervated) develops electrical inexcitability similar to…”
Get full text

Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel by Filatov, G N, Nguyen, T P, Kraner, S D, Barchi, R L

“…The D4/S4-5 interhelical region plays a role in sodium channel fast inactivation. Examination of S4-5 primary structure in all domains suggests a possible…”
Get full text

Interaction between the skeletal muscle type 1 Na+ channel promoter E-box and an upstream repressor element. Release of repression by myogenin by Kraner, S D, Rich, M M, Sholl, M A, Zhou, H, Zorc, C S, Kallen, R G, Barchi, R L

“…We have defined how four elements that regulate expression of the rat skeletal muscle type 1 sodium channel (SkM1) gene cooperate to yield specific expression…”
Get full text

Two E-Boxes Are the Focal Point of Muscle-specific Skeletal Muscle Type 1 Na+ Channel Gene Expression by Kraner, Susan D., Rich, Mark M., Kallen, Roland G., Barchi, Robert L.

“…We have characterized a group of cis-regulatory elements that control muscle-specific expression of the rat skeletal muscle type 1 sodium channel (SkM1) gene…”
Get full text

Calcineurin Triggers Reactive/Inflammatory Processes in Astrocytes and Is Upregulated in Aging and Alzheimer's Models by Norris, Christopher M, Kadish, Inga, Blalock, Eric M, Chen, Kuey-Chu, Thibault, Veronique, Porter, Nada M, Landfield, Philip W, Kraner, Susan D

“…Astrocyte reactivity (i.e., activation) and associated neuroinflammation are increasingly thought to contribute to neurodegenerative disease. However, the…”
Get full text

A Selective Role for MRF4 in Innervated Adult Skeletal Muscle: Na sub(v) 1.4 Na super(+) Channel Expression Is Reduced in MRF4-Null Mice by Thompson, AL, Filatov, G, Chen, C, Porter, I, Li, Yingjie, Rich, M M, Kraner, S D

“…The factors that regulate transcription and spatial expression of the adult skeletal muscle Na super(+) channel, Na sub(v) 1.4, are poorly understood. Here we…”
Get full text

Two E-boxes are the focal point of muscle-specific skeletal muscle type 1 Na super(+) channel gene expression by Kraner, S D, Rich, M M, Kallen, R G, Barchi, R L

“…We have characterized a group of cis-regulatory elements that control muscle-specific expression of the rat skeletal muscle type 1 sodium channel (SkM1) gene…”
Get full text

Interaction between the Skeletal Muscle Type 1 Na super(+) Channel Promoter E-box and an Upstream Repressor Element: Release of Repression by Myogenin by Kraner, S D, Rich, M M, Sholl, MA, Zhou, H, Zorc, C S, Kallen, R G, Barchi, R L

“…We have defined how four elements that regulate expression of the rat skeletal muscle type 1 sodium channel (SkM1) gene cooperate to yield specific expression…”
Get full text

Information and communication systems for the assistance of carers based on ACTION by Kraner, D. Emery, S. R. Cvetkovic, P. Procter, C. Smythe, M.

“…Recent advances in telecommunication technologies allow the design of information and communication systems for people who are caring for others in the home as…”
Get full text

A Selective Role for MRF4 in Innervated Adult Skeletal Muscle: Na V 1.4 Na + Channel Expression Is Reduced in MRF4-Null Mice by THOMPSON, AMY L., FILATOV, GREGORY, CHEN, CONNIE, PORTER, ISAAC, LI, YINGJIE, RICH, MARK M., KRANER, SUSAN D.

Get full text