Search Results - "Kramm, Christof M"

Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand? by El-Khouly, Fatma E., Veldhuijzen van Zanten, Sophie E. M., Santa-Maria Lopez, Vicente, Hendrikse, N. Harry, Kaspers, Gertjan J. L., Loizos, G., Sumerauer, David, Nysom, Karsten, Pruunsild, Kaie, Pentikainen, Virve, Thorarinsdottir, Halldora K., Rutkauskiene, Giedre, Calvagna, Victor, Drogosiewicz, Monika, Dragomir, Monica, Deak, Ladislav, Kitanovski, Lidija, von Bueren, Andre O., Kebudi, Rejin, Slavc, Irene, Jacobs, Sandra, Jadrijevic-Cvrlje, Filip, Entz-Werle, Natacha, Grill, Jacques, Kattamis, Antonis, Hauser, Peter, Pears, Jane, Biassoni, Veronica, Massimino, Maura, Lopez Aguilar, Enrique, Torsvik, Ingrid K., Joao Gil-da-Costa, Maria, Kumirova, Ella, Cruz-Martinez, Ofelia, Holm, Stefan, Bailey, Simon, Hayden, Tim, Thomale, Ulrich W., Janssens, Geert O. R., Kramm, Christof M., van Vuurden, Dannis G.

“…Introduction Diffuse intrinsic pontine glioma (DIPG) is a rare clinically, neuro-radiologically, and molecularly defined malignancy of the brainstem with a…”
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Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location by Castel, David, Philippe, Cathy, Kergrohen, Thomas, Sill, Martin, Merlevede, Jane, Barret, Emilie, Puget, Stéphanie, Sainte-Rose, Christian, Kramm, Christof M, Jones, Chris, Varlet, Pascale, Pfister, Stefan M, Grill, Jacques, Jones, David T W, Debily, Marie-Anne

“…Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and…”
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Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol by Wiek, Constanze, Schmidt, Eva M, Roellecke, Katharina, Freund, Marcel, Nakano, Mariko, Kelly, Edward J, Kaisers, Wolfgang, Yarov-Yarovoy, Vladimir, Kramm, Christof M, Rettie, Allan E, Hanenberg, Helmut

“…Mammalian CYP4B1 enzymes are cytochrome P450 mono-oxygenases that are responsible for the bioactivation of several exogenous pro-toxins including 4-ipomeanol…”
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Decreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments by Mieczkowska, Iga K., Pantelaiou-Prokaki, Garyfallia, Prokakis, Evangelos, Schmidt, Geske E., Müller-Kirschbaum, Lukas C., Werner, Marcel, Sen, Madhobi, Velychko, Taras, Jannasch, Katharina, Dullin, Christian, Napp, Joanna, Pantel, Klaus, Wikman, Harriet, Wiese, Maria, Kramm, Christof M., Alves, Frauke, Wegwitz, Florian

“…Breast cancer (BC) is the most common cancer occurring in women but also rarely develops in men. Recent advances in early diagnosis and development of targeted…”
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Intensive chemotherapy improves survival in pediatric high‐grade glioma after gross total resection: results of the HIT‐GBM‐C protocol by Wolff, Johannes E.A., Driever, Pablo Hernaiz, Erdlenbruch, Bernhard, Kortmann, Rolf D., Rutkowski, Stefan, Pietsch, Torsten, Parker, Crystal, Metz, Monica Warmuth, Gnekow, Astrid, Kramm, Christof M.

“…BACKGROUND: The authors hypothesized that intensified chemotherapy in protocol HIT‐GBM‐C would increase survival of pediatric patients with high‐grade glioma…”
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A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)” by von Bueren, André O., Karremann, Michael, Gielen, Gerrit H., Benesch, Martin, Fouladi, Maryam, van Vuurden, Dannis G., van Zanten, Sophie E. M. Veldhuijzen, Hoffman, Lindsey M., Kramm, Christof M.

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Neurological Symptom Improvement After Re-Irradiation in Patients With Diffuse Intrinsic Pontine Glioma: A Retrospective Analysis of the SIOP-E-HGG/DIPG Project by Chavaz, Lara, Janssens, Geert O, Bolle, Stephanie, Mandeville, Henry, Ramos-Albiac, Monica, Van Beek, Karen, Benghiat, Helen, Hoeben, Bianca, Morales La Madrid, Andres, Seidel, Clemens, Kortmann, Rolf-Dieter, Hargrave, Darren, Gandola, Lorenza, Pecori, Emilia, van Vuurden, Dannis G, Biassoni, Veronica, Massimino, Maura, Kramm, Christof M, von Bueren, Andre O

“…The aim of this study is to investigate the spectrum of neurological triad improvement in patients with diffuse intrinsic pontine glioma (DIPG) treated by…”
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Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity by Gielen, Gerrit H., Gessi, Marco, Buttarelli, Francesca R., Baldi, Caterina, Hammes, Jennifer, zur Muehlen, Anja, Doerner, Evelyn, Denkhaus, Dorota, Warmuth-Metz, Monika, Giangaspero, Felice, Lauriola, Libero, von Bueren, André O., Kramm, Christof M., Waha, Andreas, Pietsch, Torsten

“…Pediatric high‐grade gliomas are considered to be different when compared to adult high‐grade gliomas in their pathogenesis and biological behavior. Recently,…”
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Desmoplastic small round cell tumors: Multimodality treatment and new risk factors by Scheer, Monika, Vokuhl, Christian, Blank, Bernd, Hallmen, Erika, von Kalle, Thekla, Münter, Marc, Wessalowski, Rüdiger, Hartwig, Maite, Sparber‐Sauer, Monika, Schlegel, Paul‐Gerhardt, Kramm, Christof M., Kontny, Udo, Spriewald, Bernd, Kegel, Thomas, Bauer, Sebastian, Kazanowska, Bernarda, Niggli, Felix, Ladenstein, Ruth, Ljungman, Gustaf, Jahnukainen, Kirsi, Fuchs, Jörg, Bielack, Stefan S., Klingebiel, Thomas, Koscielniak, Ewa

“…Background To evaluate optimal therapy and potential risk factors. Methods Data of DSRCT patients <40 years treated in prospective CWS trials 1997‐2015 were…”
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Boswellic acid formulations are not suitable for treatment of pediatric high-grade glioma due to tumor promoting potential by Wiese, Maria, Pohlmeier, Bente, Kubiak, Klaudia, El-Khouly, Fatma E, Sitte, Maren, Carcaboso, Angel M, Baugh, Joshua N, Perwein, Thomas, Nussbaumer, Gunther, Karremann, Michael, Gielen, Gerrit H, Salinas, Gabriela, Kramm, Christof M

“…Background and aim: Pediatric high-grade gliomas (pedHGG) comprise a very poor prognosis. Thus, parents of affected children are increasingly resorting to…”
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A Pyrosequencing-Based Assay for the Rapid Detection of IDH1 Mutations in Clinical Samples by Setty, Prashanth, Hammes, Jennifer, Rothämel, Thomas, Vladimirova, Valentina, Kramm, Christof M, Pietsch, Torsten, Waha, Andreas

“…Mutations of both the IDH1 and IDH2 (isocitratedehydrogenase enzyme 1 and 2) genes have recently been described in cases of human glioma. Since IDH1 mutations…”
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Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM by Peterziel, Heike, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F., Herter, Sonja, Fiesel, Petra, Berker, Yannick, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C., Reuss, David, Turunen, Laura, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U., Gojo, Johannes, Hutter, Caroline, Øra, Ingrid, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert, Nathrath, Michaela, Sparber-Sauer, Monika, Sehested, Astrid, Kramm, Christof M., Dirksen, Uta, Kallioniemi, Olli, Pfister, Stefan M., van Tilburg, Cornelis M., Jones, David T. W., Saarela, Jani, Pietiäinen, Vilja, Jäger, Natalie, Schlesner, Matthias, Kopp-Schneider, Annette, Oppermann, Sina, Milde, Till, Witt, Olaf, Oehme, Ina

“…The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a…”
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Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution by Schmidt, Eva M, Wiek, Constanze, Parkinson, Oliver T, Roellecke, Katharina, Freund, Marcel, Gombert, Michael, Lottmann, Nadine, Steward, Charles A, Kramm, Christof M, Yarov-Yarovoy, Vladimir, Rettie, Allan E, Hanenberg, Helmut

“…CYP4B1 belongs to the cytochrome P450 family 4, one of the oldest P450 families whose members have been highly conserved throughout evolution. The CYP4…”
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Lenalidomide in an in vitro Dendritic Cell Model for Malignant Gliomas by Kühnöl, Caspar D, Staege, Martin S, Kramm, Christof M

“…Malignant gliomas are tumors with a very unfavorable prognosis. They are characterized by rapid proliferation and invasion in the surrounding healthy tissue…”
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Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells by Kewitz, Stefanie, Stiefel, Martina, Kramm, Christof M, Staege, Martin S

“…Abstract We analyzed the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter and mRNA expression in HL cells and assessed the…”
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H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers by Korshunov, Andrey, Schrimpf, Daniel, Ryzhova, Marina, Sturm, Dominik, Chavez, Lukas, Hovestadt, Volker, Sharma, Tanvi, Habel, Antje, Burford, Anna, Jones, Chris, Zheludkova, Olga, Kumirova, Ella, Kramm, Christof M., Golanov, Andrey, Capper, David, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.

“…Pediatric glioblastoma (pedGBM) is an extremely aggressive pediatric brain tumor, accounting for ~6% of all central nervous system neoplasms in children…”
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Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location by Karremann, Michael, Gielen, Gerrit H, Hoffmann, Marion, Wiese, Maria, Colditz, Niclas, Warmuth-Metz, Monika, Bison, Brigitte, Claviez, Alexander, van Vuurden, Dannis G, von Bueren, André O, Gessi, Marco, Kühnle, Ingrid, Hans, Volkmar H, Benesch, Martin, Sturm, Dominik, Kortmann, Rolf-Dieter, Waha, Andreas, Pietsch, Torsten, Kramm, Christof M

“…The novel entity of "diffuse midline glioma, H3 K27M-mutant" has been defined in the 2016 revision of the World Health Organization (WHO) classification of…”
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Improved Survival after Gross Total Resection of Malignant Gliomas in Pediatric Patients from the HIT-GBM Studies by KRAMM, Christof M, WAGNER, Sabine, VAN GOOL, Stefan, SCHMID, Hansjörg, STRÄTER, Ronald, GNEKOW, Astrid, RUTKOWSKI, Stefan, WOLFF, Johannes E. A

“…The present study was performed to investigate the prognostic impact of tumor resection on survival in children and adolescents with malignant gliomas. From…”
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The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets by van Tilburg, Cornelis M, Pfaff, Elke, Pajtler, Kristian W, Langenberg, Karin P S, Fiesel, Petra, Jones, Barbara C, Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D, Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E, Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M, von Bueren, André O, Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Frühwald, Michael C, Schneider, Dominik T, Brecht, Ines B, Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T, Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Øra, Ingrid, Hutter, Caroline, Gerber, Nicolas U, Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C Michel, Milde, Till, Jäger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T W, Molenaar, Jan J, Capper, David, Pfister, Stefan M, Witt, Olaf

“…INFORM is a prospective, multinational registry gathering clinical and molecular data of relapsed, progressive, or high-risk pediatric patients with cancer…”
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Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation by Castel, David, Kergrohen, Thomas, Tauziède-Espariat, Arnault, Mackay, Alan, Ghermaoui, Samia, Lechapt, Emmanuèle, Pfister, Stefan M., Kramm, Christof M., Boddaert, Nathalie, Blauwblomme, Thomas, Puget, Stéphanie, Beccaria, Kévin, Jones, Chris, Jones, David T. W., Varlet, Pascale, Grill, Jacques, Debily, Marie-Anne

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