Search Results - "Kramm, C"

Treatment of high-grade glioma in children and adolescents by MacDonald, T. J., Aguilera, D., Kramm, C. M.

“…Pediatric high-grade gliomas (HGGs)-including glioblastoma multiforme, anaplastic astrocytoma, and diffuse intrinsic pontine glioma-are difficult to treat and…”
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No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3 by Wiese, M, Schill, F, Sturm, D, Pfister, S, Hulleman, E, Johnsen, S A, Kramm, C M

“…Glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) belong to the most aggressive cancers in children with poor prognosis and limited…”
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The Bowel Function Index for Evaluating Constipation in Pain Patients: Definition of a Reference Range for a Non-Constipated Population of Pain Patients by Ueberall, MA, Müller-Lissner, S, Buschmann-Kramm, C, Bosse, B

“…Opioid-induced constipation (OIC) is a severe, persisting side-effect of opioid therapy. The Bowel Function Index (BFIa, numerical analogue scale 0 − 100),…”
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Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study by Fleischhack, G., Massimino, M., Warmuth-Metz, M., Khuhlaeva, E., Janssen, G., Graf, N., Rutkowski, S., Beilken, A., Schmid, I., Biassoni, V., Gorelishev, S. K., Kramm, C., Reinhard, H., Schlegel, P. G., Kortmann, R.-D., Reuter, D., Bach, F., Iznaga-Escobar, N. E., Bode, U.

“…Background Diffuse intrinsic pontine glioma (DIPG) is a devastating cancer of childhood and adolescence. Methods The study included patients between 3 and…”
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Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis by Ratnaparkhe, M, Hlevnjak, M, Kolb, T, Jauch, A, Maass, K K, Devens, F, Rode, A, Hovestadt, V, Korshunov, A, Pastorczak, A, Mlynarski, W, Sungalee, S, Korbel, J, Hoell, J, Fischer, U, Milde, T, Kramm, C, Nathrath, M, Chrzanowska, K, Tausch, E, Takagi, M, Taga, T, Constantini, S, Loeffen, J, Meijerink, J, Zielen, S, Gohring, G, Schlegelberger, B, Maass, E, Siebert, R, Kunz, J, Kulozik, A E, Worst, B, Jones, D T, Pfister, S M, Zapatka, M, Lichter, P, Ernst, A

“…Recent developments in sequencing technologies led to the discovery of a novel form of genomic instability, termed chromothripsis. This catastrophic genomic…”
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MR Imaging and Clinical Characteristics of Diffuse Glioneuronal Tumor with Oligodendroglioma-like Features and Nuclear Clusters by Benesch, M, Perwein, T, Apfaltrer, G, Langer, T, Neumann, A, Brecht, I B, Schuhmann, M U, Cario, H, Frühwald, M C, Vollert, K, van Buiren, M, Deng, M Y, Seitz, A, Haberler, C, Mynarek, M, Kramm, C, Sahm, F, Robe, P A, Dankbaar, J W, Hoff, K V, Warmuth-Metz, M, Bison, B

“…Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) is a new, molecularly defined glioneuronal CNS tumor type. The…”
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Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies by Roellecke, K, Virts, E L, Einholz, R, Edson, K Z, Altvater, B, Rossig, C, von Laer, D, Scheckenbach, K, Wagenmann, M, Reinhardt, D, Kramm, C M, Rettie, A E, Wiek, C, Hanenberg, H

“…Engineering autologous or allogeneic T cells to express a suicide gene can control potential toxicity in adoptive T-cell therapies. We recently reported the…”
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Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma by Karremann, M, Rausche, U, Roth, D, Kühn, A, Pietsch, T, Gielen, G H, Warmuth-Metz, M, Kortmann, R-D, Straeter, R, Gnekow, A, Wolff, J E A, Kramm, C M

“…Background: High-grade glioma (HGG) of the cerebellum accounts for only 5% of paediatric HGG. Since little is known about these tumours, the present study…”
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Phase II open-label, global study evaluating dabrafenib in combination with trametinib in pediatric patients with BRAF V600-mutant high-grade glioma (HGG) or low-grade glioma (LGG) by Hargrave, D, Witt, O, Cohen, K, Packer, R, Lissat, A, Kordes, U, Laetsch, T W, Hoffman, L, Lassaletta, A, Gerber, N U, Gilheeney, S, Holm, S, Kramm, C, Sumerauer, D, Reitmann, C, Russo, M W, Bouffet, E

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High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity by Haase, R, Elsner, K, Merkel, N, Stiefel, M, Mauz-Körholz, C, Kramm, C M, Körholz, D

“…Methotrexate (MTX) is commonly administered in high doses for treatment of childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to study…”
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Craniospinal irradiation with concurrent temozolomide for primary metastatic pediatric high-grade or diffuse intrinsic pontine gliomas: A first report from the GPOH-HIT-HGG Study Group by Müller, K., Schlamann, A., Guckenberger, M., Warmuth-Metz, M., Glück, A., Pietschmann, S., Wawer, A., Kortmann, R.-D., Kramm, C., von Bueren, A.O.

“…Background High-grade (HGG) and diffuse intrinsic pontine gliomas (DIPG) with primary metastatic spread are extremely rare and have a dismal prognosis…”
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Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells by Bienemann, K, Staege, M S, Howe, S J, Sena-Esteves, M, Hanenberg, H, Kramm, C M

“…The antifolate methotrexate (MTX) is an important chemotherapeutic agent for treatment of osteosarcoma. This drug is converted intracellularly into…”
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Leukapheresis and exchange transfusion in children with acute leukemia and hyperleukocytosis. A single center experience by Haase, R, Merkel, N, Diwan, O, Elsner, K, Kramm, C M

“…The risk of severe complications or death during the initial period of acute leukemia was markedly decreased due to the progress in pediatric oncology and use…”
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Serum cystatin C is a suitable marker for routine monitoring of renal function in pediatric cancer patients, especially of very young age by Lankisch, P., Wessalowski, R., Maisonneuve, P., Haghgu, M., Hermsen, D., Kramm, C.M.

“…Background Monitoring renal function is crucial in children undergoing chemotherapy. To date, a combination of routine serum creatinine (SCR) monitoring with…”
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How to Treat INI1 Negative Non-Rhabdoid Tumours in Adolescents: Following Genotype or Histological Phenotype? by Völker, F, Kühnle, I, Edler, J, Schildhaus, H-U, Vokuhl, C, Mohr, A, Sahlmann, C, Kramm, C M

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Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8 CD3 count reconstitution is associated with survival by KOEHL, U, BOCHENNEK, K, ORTH, A, BADER, P, SCHWABE, D, KLINGEBIEL, T, ZIMMERMANN, S. Y, LEHRNBECHER, T, SÖRENSEN, J, ESSER, R, ANDREAS, C, KRAMM, C, GRÜTTNER, H. P, FALKENBERG, E

“…To evaluate the correlation between kinetics of immune reconstitution and survival, we prospectively evaluated lymphocyte subsets in 32 paediatric patients…”
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Management of oncology patients admitted to the paediatric intensive care unit of a general children's hospital - a single center analysis by Haase, R, Lieser, U, Kramm, C, Stiefel, M, Vilser, C, Bernig, T, Merkel, N, Mauz-Körholz, C, Körholz, D

“…The improving prognosis of children with cancer has partially been attributed to the increasing importance of pediatric intensive care units (PICU). We analyze…”
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Craniospinal irradiation with concurrent temozolomide and nimotuzumab in a child with primary metastatic diffuse intrinsic pontine glioma: A compassionate use treatment by Müller, K., Schlamann, A., Seidel, C., Warmuth-Metz, M., Christiansen, H., Vordermark, D., Kortmann, R.-D., Kramm, C.M., von Bueren, A.O.

“…Primary metastatic diffuse intrinsic pontine glioma (DIPG) is relatively rare and associated with a dismal prognosis. Combining craniospinal irradiation (CSI)…”
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Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy by Kramm, C M, Chase, M, Herrlinger, U, Jacobs, A, Pechan, P A, Rainov, N G, Sena-Esteves, M, Aghi, M, Barnett, F H, Chiocca, E A, Breakefield, X O

“…A second-generation replication-conditional herpes simplex virus type 1 (HSV) vector defective for both ribonucleotide reductase (RR) and the neurovirulence…”
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Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors: An update after long-term follow-up from two centers of the European Intergroup Study EICESS by BURDACH, S, VAN KAICK, B, ENGEL, B, DIRKSEN, U, KRAMM, C, NÜRNBERGER, W, HEYLL, A, LADENSTEIN, R, GADNER, H, JÜRGENS, H, GÖBEL, U, LAWS, H. J, AHRENS, S, HAASE, R, KÖRHOLZ, D, PAPE, H, DUNST, J, KAHN, T, WILLERS, R

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