Search Results - "Kramer, Susanne"
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The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes
Published in PLoS pathogens (19-06-2017)“…5'-3' decay is the major mRNA decay pathway in many eukaryotes, including trypanosomes. After deadenylation, mRNAs are decapped by the nudix hydrolase DCP2 of…”
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Developmental regulation of gene expression in the absence of transcriptional control: The case of kinetoplastids
Published in Molecular and biochemical parasitology (01-02-2012)“…[Display omitted] ► Kinetoplastids do not regulate transcription. ► Yet, gene expression changes severely during life cycle progression. ► At what levels does…”
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Temporal variation in surface and subsoil abundance and function of the soil microbial community in an arable soil
Published in Soil biology & biochemistry (01-06-2013)“…Many studies of the microbial ecology of agricultural ecosystems focus on surface soils, whereas the impacts of management practice and season on soil…”
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Trans -acting proteins regulating mRNA maturation, stability and translation in trypanosomatids
Published in Trends in parasitology (01-01-2011)“…In trypanosomatids, alterations in gene expression in response to intrinsic or extrinsic signals are achieved through post-transcriptional mechanisms. In the…”
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The nuclear proteome of Trypanosoma brucei
Published in PloS one (20-07-2017)“…Trypanosoma brucei is a protozoan flagellate that is transmitted by tsetse flies into the mammalian bloodstream. The parasite has a huge impact on human health…”
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Resource Partitioning between Bacteria, Fungi, and Protists in the Detritusphere of an Agricultural Soil
Published in Frontiers in microbiology (26-09-2016)“…The flow of plant-derived carbon in soil is a key component of global carbon cycling. Conceptual models of trophic carbon fluxes in soil have assumed separate…”
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Disentangling carbon flow across microbial kingdoms in the rhizosphere of maize
Published in Soil biology & biochemistry (01-07-2019)“…Numerous 13CO2 labeling studies have traced the flow of carbon from fresh plant exudates into rhizosphere bacterial communities. However, the succession of the…”
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Detection of TurboID fusion proteins by fluorescent streptavidin outcompetes antibody signals and visualises targets not accessible to antibodies
Published in eLife (29-08-2024)“…Immunofluorescence localises proteins via fluorophore-labelled antibodies. However, some proteins evade detection due to antibody-accessibility issues or…”
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Comparative proteomics of the two T. brucei PABPs suggests that PABP2 controls bulk mRNA
Published in PLoS neglected tropical diseases (24-07-2018)“…Poly(A)-binding proteins (PABPs) regulate mRNA fate by controlling stability and translation through interactions with both the poly(A) tail and eIF4F complex…”
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A novel SNF2 ATPase complex in Trypanosoma brucei with a role in H2A.Z-mediated chromatin remodelling
Published in PLoS pathogens (01-06-2022)“…A cascade of histone acetylation events with subsequent incorporation of a histone H2A variant plays an essential part in transcription regulation in various…”
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Changes in bacterial community composition and soil respiration indicate rapid successions of protist grazers during mineralization of maize crop residues
Published in Pedobiologia (01-05-2017)“…•Succession of protist grazers during two phases of maize litter decomposition.•Rapid phase of residue mineralization influenced by identity of protist…”
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Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism
Published in PloS one (21-03-2018)“…The degree of conservation and evolution of cytoplasmic mRNA metabolism pathways across the eukaryotes remains incompletely resolved. In this study, we…”
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Comprehensive orthodontic treatment using miniscrews and digital rehabilitation in a patient with severe recessive dystrophic epidermolysis bullosa
Published in Special care in dentistry (01-05-2024)“…Introduction Epidermolysis bullosa (EB) is a rare genetic disorder characterized by skin fragility and blister formation. The phenotypic presentation is broad…”
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Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
Published in Nature communications (29-03-2019)“…Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the mechanisms of ligand-dependent and allosteric regulation in signalling…”
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Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major
Published in BMC genomics (05-05-2010)“…CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member,…”
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Visual Evoked Potentials Used to Evaluate a Commercially Available Superabsorbent Polymer as a Cheap and Efficient Material for Preparation-Free Electrodes for Recording Electrical Potentials of the Human Visual Cortex
Published in Sensors (Basel, Switzerland) (09-11-2019)“…The aim of this study was to investigate the use of inexpensive and easy-to-use hydrogel "marble" electrodes for the recording of electrical potentials of the…”
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The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Published in Scientific reports (15-09-2021)“…The biosynthesis of ribosomes is a complex cellular process involving ribosomal RNA, ribosomal proteins and several further trans-acting factors. DExD/H box…”
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A quorum sensing-independent path to stumpy development in Trypanosoma brucei
Published in PLoS pathogens (01-04-2017)“…For persistent infections of the mammalian host, African trypanosomes limit their population size by quorum sensing of the parasite-excreted stumpy induction…”
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Is mRNA decapping by ApaH like phosphatases present in eukaryotes beyond the Kinetoplastida?
Published in BMC ecology and evolution (23-06-2021)“…Abstract Background ApaH like phosphatases (ALPHs) originate from the bacterial ApaH protein and have been identified in all eukaryotic super-groups. Only two…”
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Differential localization of the two T. brucei poly(A) binding proteins to the nucleus and RNP granules suggests binding to distinct mRNA pools
Published in PloS one (30-01-2013)“…The number of paralogs of proteins involved in translation initiation is larger in trypanosomes than in yeasts or many metazoan and includes two poly(A)…”
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