Search Results - "Kramer, Mark S."

Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK 1) antagonists by Rupniak, Nadia M.J, Kramer, Mark S

“…The development of small-molecule antagonists of the substance P (SP)-preferring tachykinin NK 1 receptor during the past decade represents an important…”
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Demonstration of the Efficacy and Safety of a Novel Substance P (NK ) Receptor Antagonist in Major Depression by KRAMER, Mark S, WINOKUR, Andrew, APTER, Jeffrey T, CUNNINGHAM, Lynn, KLING, Mitchel, BARI, Mohammed, GETSON, Albert, YIH LEE, KELSEY, Jeffrey, PRESKORN, Sheldon H, ROTHSCHILD, Anthony J, SNAVELY, Duane, GHOSH, Kalyan, BALL, William A, REINES, Scott A, MUNJACK, Dennis

“…The efficacy and safety of a selective NK(1) antagonist, L-759274, was investigated in outpatients with diagnosis of major depressive disorder with melancholic…”
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NK1 receptor antagonists for depression: Why a validated concept was abandoned by Rupniak, Nadia M.J., Kramer, Mark S.

“…NK1 receptor antagonists were abandoned despite antidepressant efficacy in five randomized clinical trials. The loss of confidence may be attributed to the…”
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Novel strategies for pharmacotherapy of depression by Maubach, Karen A, Rupniak, Nadia MJ, Kramer, Mark S, Hill, Raymond G

“…Modulating monoamine activity as a therapeutic strategy continues to dominate antidepressant research, with a recent emphasis on agents with multiple targets,…”
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Pharmacokinetics of Rizatriptan Tablets During and Between Migraine Attacks by Cutler, Neal R., Jhee, Stanford S., Majumdar, Anup K., McLaughlin, Debra, Brucker, Mary Jo, Carides, Alexandra D., Kramer, Mark S., Matzura-Wolfe, Deborah, Reines, Scott A., Goldberg, Michael R.

“…Gastric stasis during migraine attacks results in delayed absorption of several orally administered antimigraine agents. This study, as part of a larger trial,…”
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Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors by Kramer, Mark S., Cutler, Neal, Feighner, John, Shrivastava, Ram, Carman, John, Sramek, John J., Reines, Scott A., Liu, Guanghan, Snavely, Duane, Wyatt-Knowles, Edwina, Hale, Jeffrey J., Mills, Sander G., MacCoss, Malcolm, Swain, Christopher J., Harrison, Timothy, Hill, Raymond G., Hefti, Franz, Scolnick, Edward M., Cascieri, Margaret A., Chicchi, Gary G., Sadowski, Sharon, Williams, Angela R., Hewson, Louise, Smith, David, Carlson, Emma J., Hargreaves, Richard J., Nadia M. J. Rupniak

“…The localization of substance P in brain regions that coordinate stress responses and receive convergent monoaminergic innervation suggested that substance P…”
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A placebo-controlled crossover study of rizatriptan in the treatment of multiple migraine attacks by KRAMER, M. S, MATZURA-WOLFE, D, POLIS, A, GETSON, A, AMARANENI, P. G, SOLBACH, M. P, MCHUGH, W, FEIGHNER, J, SILBERSTEIN, S, REINES, S. A

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Schizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist by Bristow, Linda J., Kramer, Mark S., Kulagowski, Jan, Patel, Smita, Ragan, C.Ian, Seabrook, Guy R.

“…The discovery of a novel high-affinity and selective dopamine D4 receptor antagonist, L-745, 870, and the results of clinical trials with this compound are…”
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Resin hemoperfusion: a new treatment for acute drug intoxication by Rosenbaum, J L, Kramer, M S, Raja, R, Boreyko, C

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Mucormycosis in a Renal Transplant Recipient With Successful Outcome by Henriquez, Mario, Levy, Richard, Raja, Rasib M, Kramer, Mark S, Rosenbaum, Jerry L

“…MUCORMYCOSIS is usually a fatal disease that occurs in patients with uncontrolled diabetes mellitus, in patients with an abnormal immunologic system such as…”
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Antidepressants in 'depressed' schizophrenic inpatients. A controlled trial by Kramer, M S, Vogel, W H, DiJohnson, C, Dewey, D A, Sheves, P, Cavicchia, S, Little, P, Schmidt, R, Kimes, I

“…Fifty-eight actively psychotic inpatients who initially met criteria for long-standing schizophrenia and subsequently met Research Diagnostic Criteria for a…”
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A placebo-controlled trial of L-365,260, a CCKB antagonist, in panic disorder by KRAMER, M. S, CUTLER, N. R, BALLENGER, J. C, PATTERSON, W. M, MENDELS, J, CHENAULT, A, RAM SHRIVASTAVA, MATZURA-WOLFE, D, LINES, C, REINES, S

“…The functional role of cholecystokinin in the central nervous system is unknown. The tetra peptide CCK-4 was previously observed to induce panic attacks in a…”
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Resin hemoperfusion for acute drug intoxication by Rosenbaum, J L, Kramer, M S, Raja, R

“…Eight patients with drug intoxication were hemoperfused on ten occasions at a blood-flow rate of 300 ml/min with a 650gm column of Amberlite XAD-4 resin, which…”
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Repeated Peritoneal Dialysis in Treatment of Heart Failure by Raja, Rasib M, Krasnoff, Sidney O, Moros, Julio G, Kramer, Mark S, Rosenbaum, Jerry L

“…A patient with refractory heart failure and anasarca underwent eight peritoneal dialyses during a 21-month period. Clinical response to the dialyses was…”
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Neutralization of sensory-input modification of seizure thresholds in rats by Kramer, Mark S, Adler, Martin W

“…Five experiments with a total of 162 male albino Sprague-Dawley rats demonstrated that exposing Ss to either intermittent sound or light stimulation…”
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Clinical evidence that substance P antagonists are well-tolerated antidepressants by Kramer, Mark S., Cutler, Neal, Feighner, John, Shrivastava, Ram, Carman, John, Liu, Guanghan, Snavely, Duane, Wyatt-Knowles, Edwina, Reines, Scott, Rupniak, Nadia

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Positive and negative symptoms during neuroleptic treatment by Kramer, M S

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A placebo-controlled trial of L-365,260, a CCK B antagonist, in panic disorder by Kramer, Mark S., Cutler, Neal R., Ballenger, James C., Patterson, William M., Mendels, Joseph, Chenault, Alice, Shrivastava, Ram, Matzura-Wolfe, Deborah, Lines, Chris, Reines, Scott

“…The functional role of cholecystokinin in the central nervous system is unknown. The tetra peptide CCK-4 was previously observed to induce panic attacks in a…”
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Heparin free dialysis: Comparative data and results in high risk patients by Caruana, Ralph J., Raja, Rasib M., Bush, Jasmine V., Kramer, Mark S., Goldstein, Stephen J.

“…Heparin free dialysis: comparative data and results in high risk patients. Heparin free hemodialysis was compared to systemic heparinization, intermittent…”
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Propranolol in the treatment of neuroleptic-induced akathisia (NIA) in schizophrenics: a double-blind, placebo-controlled study by Kramer, M S, Gorkin, R A, DiJohnson, C, Sheves, P

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