Search Results - "Kramer, Kenneth L."

Mechanisms of otoconia and otolith development by Lundberg, Yunxia Wang, Xu, Yinfang, Thiessen, Kevin D., Kramer, Kenneth L.

“…Background: Otoconia are bio‐crystals that couple mechanic forces to the sensory hair cells in the utricle and saccule, a process essential for us to sense…”
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Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration by Venero Galanternik, Marina, Kramer, Kenneth L., Piotrowski, Tatjana

“…Collective cell migration is a highly regulated morphogenetic movement during embryonic development and cancer invasion that involves the precise orchestration…”
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Teneurin trans-axonal signaling prunes topographically missorted axons by Spead, Olivia, Moreland, Trevor, Weaver, Cory J., Costa, Irene Dalla, Hegarty, Brianna, Kramer, Kenneth L., Poulain, Fabienne E.

“…Building precise neural circuits necessitates the elimination of axonal projections that have inaccurately formed during development. Although axonal pruning…”
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Yes-associated protein 65 (YAP) expands neural progenitors and regulates Pax3 expression in the neural plate border zone by Gee, Stephen T, Milgram, Sharon L, Kramer, Kenneth L, Conlon, Frank L, Moody, Sally A

“…Yes-associated protein 65 (YAP) contains multiple protein-protein interaction domains and functions as both a transcriptional co-activator and as a scaffolding…”
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Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice by Giffen, Kimberlee P, Liu, Huizhan, Yamane, Kacey L, Li, Yi, Chen, Lei, Kramer, Kenneth L, Zallocchi, Marisa, He, David Z

“…Hair cells (HCs) are the sensory receptors of the auditory and vestibular systems in the inner ears of vertebrates that selectively transduce mechanical…”
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Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells by Giffen, Kimberlee P., Liu, Huizhan, Kramer, Kenneth L., He, David Z.

“…Non-mammalian vertebrates, including zebrafish, retain the ability to regenerate hair cells (HCs) due to unknown molecular mechanisms that regulate…”
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CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression by Baker, Carly E, Marta, Aaron G, Zimmerman, Nathan D, Korade, Zeljka, Mathy, Nicholas W, Wilton, Delaney, Simeone, Timothy, Kochvar, Andrew, Kramer, Kenneth L, Stessman, Holly A F, Shibata, Annemarie

“…Carnitine palmitoyltransferase 2 (CPT2) is an inner mitochondrial membrane protein of the carnitine shuttle and is involved in the beta-oxidation of long chain…”
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HEPARAN SULFATE CORE PROTEINS IN CELL-CELL SIGNALING by Kramer, Kenneth L, Yost, H. Joseph

“…Heparan sulfate (HS) binds numerous extracellular ligands, including cell-cell signaling molecules and their signal-transducing receptors. Ligand binding sites…”
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Ectodermal Syndecan-2 Mediates Left-Right Axis Formation in Migrating Mesoderm as a Cell-Nonautonomous Vg1 Cofactor by Kramer, Kenneth L., Yost, H.Joseph

“…Heparan sulfate proteoglycans expressed on the Xenopus animal cap ectoderm have been implicated in transmitting left-right information to heart and gut…”
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Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy by Zhang, Zhen, Alpert, Deanne, Francis, Richard, Chatterjee, Bishwanath, Yu, Qing, Tansey, Terry, Sabol, Steven L, Cui, Cheng, Bai, Yongli, Koriabine, Maxim, Yoshinaga, Yuko, Cheng, Jan-Fang, Chen, Feng, Martin, Joel, Schackwitz, Wendy, Gunn, Teresa M, Kramer, Kenneth L, De Jong, Pieter J, Pennacchio, Len A, Lo, Cecilia W

“…Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene discovery, but mutation identification is often difficult. We present…”
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Specific sides to multifaceted glycosaminoglycans are observed in embryonic development by Kramer, Kenneth L.

“…Ubiquitously found in the extracellular matrix and attached to the surface of most cells, glycosaminoglycans (GAGs) mediate many intercellular interactions…”
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RNA-seq transcriptomic analysis of adult zebrafish inner ear hair cells by Barta, Cody L., Liu, Huizhan, Chen, Lei, Giffen, Kimberlee P., Li, Yi, Kramer, Kenneth L., Beisel, Kirk W., He, David Z.

“…Although hair cells are the sensory receptors of the auditory and vestibular systems in the ears of all vertebrates, hair cell properties are different between…”
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The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity by Gorsi, Bushra, Liu, Feng, Ma, Xing, Chico, Timothy J. A., Shrinivasan, Ashok, Kramer, Kenneth L., Bridges, Esther, Monteiro, Rui, Harris, Adrian L., Patient, Roger, Stringer, Sally E.

“…Arterial and venous specification is critical for establishing and maintaining a functioning vascular system, and defects in key arteriovenous signaling…”
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Zebrafish otolith biomineralization requires polyketide synthase by Thiessen, Kevin D., Grzegorski, Steven J., Chin, Yvonne, Higuchi, Lisa N., Wilkinson, Christopher J., Shavit, Jordan A., Kramer, Kenneth L.

“…Deflecting biomineralized crystals attached to vestibular hair cells are necessary for maintaining balance. Zebrafish (Danio rerio) are useful organisms to…”
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Stereocilin Paralogs Have Distinct Roles in Zebrafish Inner Ear Development by Kramer, Kenneth L, Inserra, Christopher J

“…Abstract only In the vertebrate inner ear, sound and movement are transduced into electrical signals by specialized bundles of cilia on the apical surface of…”
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The Otolithic Membrane Mediates Otolith Organization by Kramer, Kenneth L., Thiessen, Kevin D.

“…Abstract only Otoconia are small biocrystals that link mechanical forces to the sensory hair cells in the mammalian utricle and saccule, a process essential…”
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Coordination of dorsoventral axis formation by multiple heparan sulfate proteoglycans by Kramer, Kenneth L

“…Heparan sulfate proteoglycans are essential mediators of multiple cell‐cell signaling pathways during embryonic development. To better understand how glypicans…”
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Determinants of E-Business Use in U.S. Firms by Hsu, Pei-Fang, Kraemer, Kenneth L., Dunkle, Debora

“…The factors leading to variations in e-business use among U.S. firms are identified. Building on diffusion of innovation theory, an integrated model is…”
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Essential anatomy for core clerkships: A clinical perspective by Keim, Sarah A., Harmon, Derek J., Martindale, James R., Lopez, Elisabeth N., Sanky, Charles, Brooks, William S., Cotter, Meghan M., Davies, David L., Doroudi, Majid, Fahl, Jeffrey C., Farias, Anna, Granite, Guinevere, Harrell, Kelly M., Kar, Rekha, Kramer, Kenneth L., Jackson, Jon, Jones, Shiloh, Lackey‐Cornelison, Wendy, Laitman, Jeffrey T., Latacha, Kimberly, Lewis, Steven R., Lovejoy Mork, Amy, Marzban, Hassan, McNary, Thomas G., McWhorter, David L., Merchant, Aftab, Mussell, Jason C., Quinn, Melissa M., Reidenberg, Joy S., Royer, Danielle, Sakaguchi, Alan, Sawyer, F. Kip, Topping, Daniel B., Wainman, Bruce, Wineski, Lawrence E., Zumwalt, Ann C., Hankin, Mark H.

“…Clerkships are defining experiences for medical students in which students integrate basic science knowledge with clinical information as they gain experience…”
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Identifying and characterizing peptides that bind to specific heparan sulfate disaccharides by Thomas, Ajay, Kramer, Kenneth L

“…Many cell‐cell signaling pathways that control early development are regulated by heparan sulfate (HS), an unbranched oligosaccharide chain that is composed of…”
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