Search Results - "Kramer, Jessica R."

Multimodal Switching of Conformation and Solubility in Homocysteine Derived Polypeptides by Kramer, Jessica R, Deming, Timothy J

“…We report the design and synthesis of poly(S-alkyl-l-homocysteine)s, which were found to be a new class of readily prepared, multiresponsive polymers that…”
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The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins by Malaker, Stacy A., Pedram, Kayvon, Ferracane, Michael J., Bensing, Barbara A., Krishnan, Venkatesh, Pett, Christian, Yu, Jin, Woods, Elliot C., Kramer, Jessica R., Westerlind, Ulrika, Dorigo, Oliver, Bertozzi, Carolyn R.

“…Mucin domains are densely O-glycosylated modular protein domains that are found in a wide variety of cell surface and secreted proteins. Mucin-domain…”
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Preparation of Multifunctional and Multireactive Polypeptides via Methionine Alkylation by Kramer, Jessica R, Deming, Timothy J

“…We report the development of a new “click”-type reaction for polypeptide modification based on the chemoselective alkylation of thioether groups in methionine…”
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Chemically tunable mucin chimeras assembled on living cells by Kramer, Jessica R., Onoa, Bibiana, Bustamante, Carlos, Bertozzi, Carolyn R.

“…Mucins are a family of secreted and transmembrane glycoproteins characterized by a massive domain of dense O-glycosylation on serine and threonine residues…”
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Glycopolypeptides via Living Polymerization of Glycosylated-l-lysine N-Carboxyanhydrides by Kramer, Jessica R, Deming, Timothy J

“…The preparation of new glycosylated-l-lysine-N-carboxyanhydride (glyco-K NCA) monomers is described. These monomers employ C-linked sugars and amide linkages…”
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Mirror Image Mucins and Thio Mucins with Tunable Biodegradation by Kohout, Victoria R., Wardzala, Casia L., Kramer, Jessica R.

“…Mucin glycoproteins are the major component of mucus and are integral to the cellular glycocalyx. Mucins play diverse roles in health and disease, are an…”
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Tunable, biodegradable grafting-from glycopolypeptide bottlebrush polymers by Clauss, Zachary S., Wardzala, Casia L., Schlirf, Austin E., Wright, Nathaniel S., Saini, Simranpreet S., Onoa, Bibiana, Bustamante, Carlos, Kramer, Jessica R.

“…The cellular glycocalyx and extracellular matrix are rich in glycoproteins and proteoglycans that play essential physical and biochemical roles in all life…”
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Mucins Inhibit Coronavirus Infection in a Glycan-Dependent Manner by Wardzala, Casia L, Wood, Amanda M, Belnap, David M, Kramer, Jessica R

“…Mucins are a diverse and heterogeneous family of glycoproteins that comprise the bulk of mucus and the epithelial glycocalyx. Mucins are intimately involved in…”
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Clickable Polyprolines from Azido-proline N‑Carboxyanhydride by Detwiler, Rachel E., McPartlon, Thomas J., Coffey, Clara S., Kramer, Jessica R.

“…Polyproline is a material of great interest in biomedicine due to its helical scaffold of structural importance in collagen and mucins and its ability to gel…”
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Principles of glycocalyx engineering with hydrophobic-anchored synthetic mucins by Wardzala, Casia L, Clauss, Zachary S, Kramer, Jessica R

“…The cellular glycocalyx is involved in diverse biological phenomena in health and disease. Yet, molecular level studies have been challenged by a lack of tools…”
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Theme issue: In vitro mucus models by Kramer, Jessica, Ribbeck, Katharina

“…[Display omitted]…”
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Glycopolypeptides with a Redox-Triggered Helix-to-Coil Transition by Kramer, Jessica R, Deming, Timothy J

“…Conformation-switchable glycopolypeptides were prepared by the living polymerization of glycosylated l-cysteine-N-carboxyanhydride (glyco-C NCA) monomers…”
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Rethinking Transition Metal Catalyzed N‑Carboxyanhydride Polymerization: Polymerization of Pro and AcOPro N‑Carboxyanhydrides by Detwiler, Rachel E, Schlirf, Austin E, Kramer, Jessica R

“…Polyproline (PP) based polypeptides have broad applications as protein mimics, ordered materials, hydrogels, and surface coatings. However, a lack of rapid and…”
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Design, synthesis and biological applications of glycopolypeptides by Clauss, Zachary S., Kramer, Jessica R.

“…Carbohydrates play essential structural and biochemical roles in all living organisms. Glycopolymers are attractive as well-defined biomimetic analogs to study…”
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Polypeptoids and Peptoid–Peptide Hybrids by Transition Metal Catalysis by Clauss, Zachary S., Kramer, Jessica R.

“…Peptoids have attracted attention for application in biomedicine due to their advantageous properties as compared to peptides. The structural analogues are…”
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Enzyme-Triggered Cargo Release from Methionine Sulfoxide Containing Copolypeptide Vesicles by Rodriguez, April R, Kramer, Jessica R, Deming, Timothy J

“…We have developed a facile, scalable method for preparation of enzyme-responsive copolypeptide vesicles that requires no protecting groups or expensive…”
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Biomimetic Glycosylated Polythreonines by N‑Carboxyanhydride Polymerization by Deleray, Anna C, Kramer, Jessica R

“…Glycosylated threonine (Thr) is a structural motif found in seemingly disparate natural proteins from deep-sea collagen to mucins. Synthetic mimics of these…”
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Synthesis and biomedical applications of mucin mimic materials by Kohout, Victoria R., Wardzala, Casia L., Kramer, Jessica R.

“…[Display omitted] Mucin glycoproteins are the major component of mucus and coat epithelial cell surfaces forming the glycocalyx. The glycocalyx and mucus are…”
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Preparation and applications of artificial mucins in biomedicine by Detwiler, Rachel E., Kramer, Jessica R.

“…•Mucins are the major component of mucus, which hydrates and protects tissues.•Mucins are involved in lubrication, cancer, infection, and…”
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Reversible chemoselective tagging and functionalization of methionine containing peptides by Kramer, Jessica R, Deming, Timothy J

“…Reagents were developed to allow chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal functionalization of the…”
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