Search Results - "Kramer, Cynthia S M"

A Comprehensive Evaluation of the Antibody-Verified Status of Eplets Listed in the HLA Epitope Registry by Bezstarosti, Suzanne, Bakker, Kim H, Kramer, Cynthia S M, de Fijter, Johan W, Reinders, Marlies E J, Mulder, Arend, Claas, Frans H J, Heidt, Sebastiaan

“…Matching strategies based on HLA eplets instead of HLA antigens in solid organ transplantation may not only increase the donor pool for highly sensitized…”
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HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes by Bezstarosti, Suzanne, Kramer, Cynthia S M, Franke-van Dijk, Marry E I, Vergunst, Manon, Bakker, Kim H, Uyar-Mercankaya, Merve, Buchli, Rico, Roelen, Dave L, de Fijter, Johan W, Claas, Frans H J, Heidt, Sebastiaan

“…HLA-DQ donor-specific antibodies (DSA) are the most prevalent type of DSA after renal transplantation and have been associated with eplet mismatches between…”
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HLA‐EMMA: A user‐friendly tool to analyse HLA class I and class II compatibility on the amino acid level by Kramer, Cynthia S. M., Koster, Johan, Haasnoot, Geert W., Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

“…In renal transplantation, polymorphic amino acids on mismatched donor HLA molecules can lead to the induction of de novo donor‐specific antibodies (DSA), which…”
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Introduction of the donor centre virtual crossmatch in Eurotransplant by Heidt, Sebastiaan, Kramer, Cynthia S. M., Haasnoot, Geert W., Schmidt, Alexander H., Zoet, Yvonne M., Claas, Frans H. J., Vogelaar, Serge

“…On 24 January 2023, Eurotransplant has introduced the virtual crossmatch for kidney and pancreas allocation as a better alternative for the physical Complement…”
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Implementation of molecular matching in transplantation requires further characterization of both immunogenicity and antigenicity of individual HLA epitopes by Bezstarosti, Suzanne, Kramer, Cynthia S.M., Claas, Frans H.J., de Fijter, Johan W., Reinders, Marlies E.J., Heidt, Sebastiaan

“…Over the past decade, high HLA epitope mismatch scores have been associated with inferior transplant outcomes using several tools, of which HLAMatchmaker is…”
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Using cloud infrastructure to facilitate data collection and conversion of HLA diagnostic data for the 18th International HLA and Immunogenetics Workshop by Matern, Benedict M., Niemann, Matthias, Nemparis, Ioannis, Schimanski, Andreas, Peereboom, Emma T. M., Kramer, Cynthia S. M., Heidt, Sebastiaan, Spierings, Eric

“…The International HLA and Immunogenetics Workshop (IHIW) is a recurring gathering of researchers, technologists and clinicians where participants contribute to…”
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Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA‐DR by Kramer, Cynthia S. M., Franke‐van Dijk, Marry E. I., Bakker, Kim H., Uyar‐Mercankaya, Merve, Karahan, Gonca E., Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

“…In kidney transplantation, eplet mismatches between donor and recipient have been associated with de novo donor‐specific antibody development. Eplets are…”
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Foetal Microchimerism Correlates With Foetal‐Maternal Histocompatibility Both During Pregnancy and Postpartum by Staff, Anne Cathrine, Fjeldstad, Heidi E., Olsen, Maria B., Øgaard, Jonas, Viken, Marte K., Kramer, Cynthia S. M., Eikmans, Michael, Kroneis, Thomas, Sallinger, Katja, Kanaan, Sami B., Sugulle, Meryam, Jacobsen, Daniel P.

“…ABSTRACT Foetal cells are detectable in women decades postpartum, a state termed foetal microchimerism. The interplay between these semi‐allogeneic foetal…”
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Qualitative, rather than quantitative, differences between HLA‐DQ alleles affect HLA‐DQ immunogenicity in organ transplantation by Maguire, Chelsea, Crivello, Pietro, Fleischhauer, Katharina, Isaacson, Dylan, Casillas, Aurora, Kramer, Cynthia S. M., Copley, Hannah C., Heidt, Sebastiaan, Kosmoliaptsis, Vasilis, Meneghini, Maria, Gmeiner, Michael, Schold, Jesse, Louzoun, Yoram, Tambur, Anat R.

“…Prolonging the lifespan of transplanted organs is critical to combat the shortage of this life‐saving resource. Chronic rejection, with irreversible demise of…”
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Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy by van der Waart, Anniek B., Noortje van de Weem, M.P., Maas, Frans, Kramer, Cynthia S.M., Michel Kester, G.D., Frederik Falkenburg, J.H., Schaap, Nicolaas, Jansen, Joop H., van der Voort, Robbert, Gattinoni, Luca, Hobo, Willemijn, Dolstra, Harry

“…Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell–like T cells with the ability to self-renew and differentiate…”
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Antibody verification of HLA class I and class II eplets by human monoclonal HLA antibodies by Kramer, Cynthia S. M., Bezstarosti, Suzanne, Franke‐van Dijk, Marry E. I., Vergunst, Manon, Roelen, Dave L., Uyar‐Mercankaya, Merve, Voogt‐Bakker, Kim H., Heidt, Sebastiaan

“…In solid organ transplantation, formation of de novo donor‐specific HLA antibodies is induced by mismatched eplets on donor HLA molecules. While several…”
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HLA antibody affinity determination: From HLA‐specific monoclonal antibodies to donor HLA specific antibodies (DSA) in patient serum by Hug, Melanie N., Keller, Sabrina, Marty, Talea, Gygax, Daniel, Meinel, Dominik, Spies, Peter, Handschin, Joëlle, Kleiser, Marc, Vazquez, Noemi, Linnik, Janina, Buchli, Rico, Claas, Frans, Heidt, Sebastiaan, Kramer, Cynthia S. M., Bezstarosti, Suzanne, Lee, Jar‐How, Schaub, Stefan, Hönger, Gideon

“…Organs transplanted across donor‐specific HLA antibodies (DSA) are associated with a variety of clinical outcomes, including a high risk of acute kidney graft…”
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Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation by Dijkstra, Douwe J, van de Bovenkamp, Fleur S, Abendstein, Leoni, Zuijderduijn, Rob, Pool, Jos, Kramer, Cynthia S M, Slot, Linda M, Drijfhout, Jan W, de Vor, Lisanne, Gelderman, Kyra A, Rooijakkers, Suzan H M, Zaldumbide, Arnaud, Vidarsson, Gestur, Sharp, Thomas H, Parren, Paul W H I, Trouw, Leendert A

“…Autoantibodies directed against complement component C1q are commonly associated with autoimmune diseases, especially systemic lupus erythematosus…”
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Site‐directed mutagenesis of HLA molecules reveals the functional epitope of a human HLA‐A1/A36‐specific monoclonal antibody by Meng, Tina, Bezstarosti, Suzanne, Singh, Ujjwala, Yap, Michelle, Scott, Laura, Petrosyan, Naiiry, Quiroz, Fred, Eps, Ned Van, Hui, Eric Ka‐Wai, Suh, David, Zhu, Quansheng, Pei, Rui, Kramer, Cynthia S. M., Claas, Frans H. J., Lowe, David, Heidt, Sebastiaan

“…Eplet 44KM is currently listed in the HLA Epitope Registry but does not adhere to the eplet definition of an amino acid configuration within a 3.5 Å radius…”
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The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation: a case series by Daniëls, Liesbeth, Claas, Frans H.J., Kramer, Cynthia S.M., Senev, Aleksandar, Vanden Driessche, Marleen, Emonds, Marie-Paule, Van Laecke, Steven, Hellemans, Rachel, Abramowicz, Daniel, Naesens, Maarten

“…Background: The impact of HLA-DP mismatches on renal allograft outcome is still poorly understood and is suggested to be less than that of the other HLA loci…”
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Taurocholate Induces Biliary Differentiation of Liver Progenitor Cells Causing Hepatic Stellate Cell Chemotaxis in the Ductular Reaction: Role in Pediatric Cystic Fibrosis Liver Disease by Pozniak, Katarzyna N, Pearen, Michael A, Pereira, Tamara N, Kramer, Cynthia S M, Kalita-De Croft, Priyakshi, Nawaratna, Sujeevi K, Fernandez-Rojo, Manuel A, Gobert, Geoffrey N, Tirnitz-Parker, Janina E E, Olynyk, John K, Shepherd, Ross W, Lewindon, Peter J, Ramm, Grant A

“…Cystic fibrosis liver disease (CFLD) in children causes progressive fibrosis leading to biliary cirrhosis; however, its cause(s) and early pathogenesis are…”
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Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets by Rijkers, Maaike, Schmidt, David, Lu, Nina, Kramer, Cynthia S M, Heidt, Sebastiaan, Mulder, Arend, Porcelijn, Leendert, Claas, Frans H J, Leebeek, Frank W G, Jansen, A J Gerard, Jongerius, Ilse, Zeerleder, Sacha S, Vidarsson, Gestur, Voorberg, Jan, de Haas, Masja

“…High titers of HLA antibodies are associated with platelet refractoriness, causing poor platelet increments after transfusions in a subset of patients with HLA…”
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Low incidence of IgA isotype of HLA antibodies in alloantigen exposed individuals by Car, Helena, Karahan, Gonca E., Dreyer, Geertje J., Brand‐Schaaf, Simone H., Vries, Aiko P. J., Kooten, Cees, Kramer, Cynthia S. M., Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

“…Human leukocyte antigen (HLA) antibodies are induced by pregnancy, transfusion, or transplantation. Serum from transplant recipients is regularly screened for…”
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Permissible HLA mismatches in 9/10 unrelated donor pediatric stem cell transplants using HLA-EMMA: an EBMT Inborn Errors Working Party study by von Asmuth, Erik G. J., Hiensch, Fleur, Heidt, Sebastiaan, Mohseny, Alexander B., Roelen, Dave L., Kramer, Cynthia S. M., Claas, Frans H. J., Albert, Michael H., Neven, Bénédicte, Lankester, Arjan C., van Beek, Adriaan A.

“…•Using HLA-EMMA, a subgroup of 9/10 HLA-mismatched transplants with a permissible mismatch can be identified with favorable EFS.•Permissibly mismatched…”
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Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope: Excellent tools to study differential effects of donor‐specific antibodies by Kramer, Cynthia S. M., Franke‐van Dijk, Marry E. I., Priddey, Ashley J., Pongrácz, Tamás, Gnudi, Elena, Car, Helena, Karahan, Gonca E., Beelen, Els, Zilvold‐van den Oever, Chalana C. C., Rademaker, Hendrik J., Haan, Noortje, Wuhrer, Manfred, Kosmoliaptsis, Vasilis, Parren, Paul W. H. I., Mulder, Arend, Roelen, Dave L., Claas, Frans H. J., Heidt, Sebastiaan

“…In the field of transplantation, the humoural immune response against mismatched HLA antigens of the donor is associated with inferior graft survival, but not…”
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