Search Results - "Kramer, Alwin"

PML promotes senescence via JAK/STAT signaling by Kramer, Alwin

“…Comment on: Hubackova S, et al. Cell Cycle 2010; 9:3085-99…”
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Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal by Koledova, Zuzana, Krämer, Alwin, Kafkova, Leona Raskova, Divoky, Vladimir

“…Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by…”
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Does Cancer of Unknown Primary (CUP) Truly Exist as a Distinct Cancer Entity? by Bochtler, Tilmann, Krämer, Alwin

“…Cancer of unknown primary (CUP) designates an enigmatic cancer entity with histologic confirmation of malignancy from a metastasis but no identifiable primary…”
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Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Origin: Retrospective Molecular Classification Considering the CUPISCO Study Design by Ross, Jeffrey S., Sokol, Ethan S., Moch, Holger, Mileshkin, Linda, Baciarello, Giulia, Losa, Ferran, Beringer, Andreas, Thomas, Marlene, Elvin, Julia A., Ngo, Nhu, Jin, Dexter X., Krämer, Alwin

“…Background Carcinoma of unknown primary origin (CUP) accounts for 2%–5% of newly diagnosed advanced malignancies, with chemotherapy as the standard of care…”
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Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial by Cortes, Jorge, Perl, Alexander E, Döhner, Hartmut, Kantarjian, Hagop, Martinelli, Giovanni, Kovacsovics, Tibor, Rousselot, Philippe, Steffen, Björn, Dombret, Hervé, Estey, Elihu, Strickland, Stephen, Altman, Jessica K, Baldus, Claudia D, Burnett, Alan, Krämer, Alwin, Russell, Nigel, Shah, Neil P, Smith, Catherine C, Wang, Eunice S, Ifrah, Norbert, Gammon, Guy, Trone, Denise, Lazzaretto, Deborah, Levis, Mark

“…Old age and FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukaemia are associated with early…”
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High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B‐cell chronic lymphocytic leukemia by Hensel, Manfred, Zoz, Martin, Giesecke, Christian, Benner, Axel, Neben, Kai, Jauch, Anna, Stilgenbauer, Stephan, Ho, Anthony D., Krämer, Alwin

“…B‐cell chronic lymphocytic leukemia (CLL) is characterized by a high rate of clonal genomic alterations and a low proliferative activity with cell cycle arrest…”
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A Challenging Task: Identifying Patients with Cancer of Unknown Primary (CUP) According to ESMO Guidelines: The CUPISCO Trial Experience by Pauli, Chantal, Bochtler, Tilmann, Mileshkin, Linda, Baciarello, Giulia, Losa, Ferran, Ross, Jeffrey S., Pentheroudakis, George, Zarkavelis, George, Yalcin, Suayib, Özgüroğlu, Mustafa, Beringer, Andreas, Scarato, Jeremy, Mueller‐Ohldach, Mathis, Thomas, Marlene, Moch, Holger, Krämer, Alwin

“…Background CUPISCO is an ongoing randomized phase II trial (NCT03498521) comparing molecularly guided therapy versus platinum‐based chemotherapy in patients…”
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The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy by Homan, Claire C, King-Smith, Sarah L, Lawrence, David M, Arts, Peer, Feng, Jinghua, Andrews, James, Armstrong, Mark, Ha, Thuong, Dobbins, Julia, Drazer, Michael W, Yu, Kai, Bödör, Csaba, Cantor, Alan, Cazzola, Mario, Degelman, Erin, DiNardo, Courtney D, Duployez, Nicolas, Favier, Remi, Fröhling, Stefan, Fitzgibbon, Jude, Klco, Jeffery M, Krämer, Alwin, Kurokawa, Mineo, Lee, Joanne, Malcovati, Luca, Morgan, Neil V, Natsoulis, Georges, Owen, Carolyn, Patel, Keyur P, Preudhomme, Claude, Raslova, Hana, Rienhoff, Hugh, Ripperger, Tim, Schulte, Rachael, Tawana, Kiran, Velloso, Elvira, Yan, Benedict, Liu, Paul, Godley, Lucy A, Schreiber, Andreas W, Hahn, Christopher N, Scott, Hamish S, Brown, Anna L

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HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells by Figueroa-Vazquez, Vianihuini, Ko, Jonathan, Breunig, Christian, Baumann, Anja, Giesen, Nicola, Pálfi, Anikó, Müller, Christoph, Lutz, Christian, Hechler, Torsten, Kulke, Michael, Müller-Tidow, Carsten, Krämer, Alwin, Goldschmidt, Hartmut, Pahl, Andreas, Raab, Marc S

“…Despite major treatment advances in recent years, patients with multiple myeloma inevitably relapse. The RNA polymerase II complex has been identified as a…”
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Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues by Cosenza, Marco Raffaele, Krämer, Alwin

“…Centrosomes, the main microtubule-organizing centers in most animal cells, are of crucial importance for the assembly of a bipolar mitotic spindle and…”
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Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia? by Röllig, Christoph, Kramer, Michael, Schliemann, Christoph, Mikesch, Jan-Henrik, Steffen, Björn, Krämer, Alwin, Noppeney, Richard, Schäfer-Eckart, Kerstin, Krause, Stefan W., Hänel, Mathias, Herbst, Regina, Kunzmann, Volker, Einsele, Hermann, Jost, Edgar, Brümmendorf, Tim H., Scholl, Sebastian, Hochhaus, Andreas, Neubauer, Andreas, Sohlbach, Kristina, Fransecky, Lars, Kaufmann, Martin, Niemann, Dirk, Schaich, Markus, Frickhofen, Norbert, Kiani, Alexander, Heits, Frank, Krümpelmann, Ulrich, Kaiser, Ulrich, Kullmer, Johannes, Wass, Maxi, Stölzel, Friedrich, von Bonin, Malte, Middeke, Jan Moritz, Thiede, Christian, Schetelig, Johannes, Berdel, Wolfgang E., Ehninger, Gerhard, Baldus, Claudia D., Müller-Tidow, Carsten, Platzbecker, Uwe, Serve, Hubert, Bornhäuser, Martin

“…In fit patients with newly diagnosed acute myeloid leukemia (AML), immediate treatment start is recommended due to the poor prognosis of untreated acute…”
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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease by Karakaya, Kadin, Ball, Claudia, Ott, Marion G, Seger, Reinhard, Schultze-Strasser, Stephan, Grez, Manuel, Koehl, Ulrike, Preiss, Carolin, Kinner, Andrea, von Kalle, Christof, Stein, Stefan, Schwäble, Joachim, Kühlcke, Klaus, Göhring, Gudrun, Jauch, Anna, Martin, Hans, Schwarzwaelder, Kerstin, Schmidt, Manfred, Yang, Rongxi, Thrasher, Adrian J, Tchatchou, Sandrine, Glimm, Hanno, Krämer, Alwin, Schlegelberger, Brigitte, Reinecke, Petra, Hofmann, Wolf-Karsten, Burwinkel, Barbara, Hoelzer, Dieter

“…Transduced hematopoietic stem cells can benefit patients with X-linked chronic granulomatous disease (a genetic immunodeficiency), but it's not risk free. In…”
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Safety and efficacy of BAY1436032 in IDH1-mutant AML: phase I study results by Heuser, Michael, Palmisiano, Neil, Mantzaris, Ioannis, Mims, Alice, DiNardo, Courtney, Silverman, Lewis R., Wang, Eunice S., Fiedler, Walter, Baldus, Claudia, Schwind, Sebastian, Pardee, Timothy, Perl, Alexander E., Cai, Charles, Kaulfuss, Stefan, Lagkadinou, Eleni, Rentzsch, Christine, Wagner, Markus, Wilkinson, Gary, Wu, Bingyan, Jeffers, Michael, Genvresse, Isabelle, Krämer, Alwin

“…The mutant IDH1 (mIDH1) inhibitor BAY1436032 demonstrated robust activity in preclinical AML models, supporting clinical evaluation. In the current…”
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Sorafenib in Combination With Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial by SERVE, Hubert, KRUG, Utz, FISCHER, Thomas, GIAGOUNIDIS, Aristoteles, NEUBAUER, Andreas, REICHLE, Albrecht, AULITZKY, Walter, NOPPENEY, Richard, BLAU, Igor, KUNZMANN, Volker, STUHLMANN, Reingard, KRÄMER, Alwin, WAGNER, Ruth, KREUZER, Karl-Anton, BRANDTS, Christian, STEFFEN, Björn, THIEDE, Christian, MÜLLER-TIDOW, Carsten, EHNINGER, Gerhard, BERDEL, Wolfgang E, SAUERLAND, M. Cristina, HEINECKE, Achim, BRUNNBERG, Uta, SCHAICH, Markus, OTTMANN, Oliver, DUYSTER, Justus, WANDT, Hannes

“…The prognosis of elderly patients with acute myeloid leukemia (AML) is still dismal even with intensive chemotherapy. In this trial, we compared the…”
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Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen by REBACZ, Blanka, LARSEN, Thomas O, CLAUSEN, Mads H, RØNNEST, Mads H, LÖFFLER, Harald, HO, Anthony D, KRÄMER, Alwin

“…A major drawback of cancer chemotherapy is the lack of tumor-specific targets which would allow for the selective eradication of malignant cells without…”
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The clinical mutatome of core binding factor leukemia by Opatz, Sabrina, Bamopoulos, Stefanos A., Metzeler, Klaus H., Herold, Tobias, Ksienzyk, Bianka, Bräundl, Kathrin, Tschuri, Sebastian, Vosberg, Sebastian, Konstandin, Nikola P., Wang, Christine, Hartmann, Luise, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Thiede, Christian, Middeke, Jan Moritz, Stölzel, Friedrich, Röllig, Christoph, Schetelig, Johannes, Ehninger, Gerhard, Krämer, Alwin, Braess, Jan, Görlich, Dennis, Sauerland, Maria Cristina, Berdel, Wolfgang E., Wörmann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K., Greif, Philipp A.

“…The fusion genes CBFB / MYH11 and RUNX1 / RUNX1T1 block differentiation through disruption of the core binding factor (CBF) complex and are found in 10–15% of…”
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STIL overexpression shortens lifespan and reduces tumor formation in mice by Moussa, Amira-Talaat, Cosenza, Marco R, Wohlfromm, Timothy, Brobeil, Katharina, Hill, Anthony, Patrizi, Annarita, Müller-Decker, Karin, Holland-Letz, Tim, Jauch, Anna, Kraft, Bianca, Krämer, Alwin

“…Centrosomes are the major microtubule organizing centers of animal cells. Supernumerary centrosomes are a common feature of human tumors and associated with…”
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Centrosome clustering and chromosomal (in)stability: A matter of life and death by Krämer, Alwin, Maier, Bettina, Bartek, Jiri

“…Centrosome abnormalities occur commonly in cancer, and contribute to chromosomal instability and tumorigenesis. New evidence on a phylogenetically conserved…”
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Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trial by Pouyiourou, Maria, Kraft, Bianca N., Wohlfromm, Timothy, Stahl, Michael, Kubuschok, Boris, Löffler, Harald, Hacker, Ulrich T., Hübner, Gerdt, Weiss, Lena, Bitzer, Michael, Ernst, Thomas, Schütt, Philipp, Hielscher, Thomas, Delorme, Stefan, Kirchner, Martina, Kazdal, Daniel, Ball, Markus, Kluck, Klaus, Stenzinger, Albrecht, Bochtler, Tilmann, Krämer, Alwin

“…Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-based chemotherapy. 10-20% of patients have a high tumor mutational…”
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Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization by Konotop, Gleb, Bausch, Elena, Nagai, Tomoaki, Turchinovich, Andrey, Becker, Natalia, Benner, Axel, Boutros, Michael, Mizuno, Kensaku, Krämer, Alwin, Raab, Marc Steffen

“…Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra…”
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