Search Results - "Kralova, Barbora"
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1
NSE5 subunit interacts with distant regions of the SMC arms in the Physcomitrium patens SMC5/6 complex
Published in The Plant journal : for cell and molecular biology (01-08-2024)“…SUMMARY Structural maintenance of chromosome (SMC) complexes play roles in cohesion, condensation, replication, transcription, and DNA repair. Their cores are…”
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2
Evaluation of Stallions Based on Linear Description of Their Daughters
Published in Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis (2017)“…The purpose of our work was an objective evaluation of mares of the Czech warmblood horse based on the linear description, as well as the evaluation of the…”
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3
Aging-Related Changes in Erythropoietic Activity and Iron Metabolism in a Mouse Model of Congenital Erythrocytosis with Human Gain-of-Function Erythropoietin Receptor
Published in Blood (23-11-2021)“…We previously created and characterized a mouse model of congenital erythrocytosis with low erythropoietin (EPO) levels from a gain-of-function mutation of the…”
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4
Developmental changes in iron metabolism and erythropoiesis in mice with human gain‐of‐function erythropoietin receptor
Published in American journal of hematology (01-10-2022)“…Iron availability for erythropoiesis is controlled by the iron‐regulatory hormone hepcidin. Increased erythropoiesis negatively regulates hepcidin synthesis by…”
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5
Elevated erythroferrone distinguishes erythrocytosis with inherited defects in oxygen‐sensing pathway from primary familial and congenital polycythaemia
Published in British journal of haematology (01-08-2023)“…Congenital erythrocytoses represent a heterogenous group of rare defects of erythropoiesis characterized by elevated erythrocyte mass. We performed…”
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6
Inflammatory Signature, Oxidative Stress, and DNA Damage Response in DBA Pathogenesis
Published in Blood (08-12-2017)“…Diamond-Blackfan anemia (DBA) is an inherited pure red cell aplasia caused mostly by pathogenic variants in genes encoding for ribosomal proteins (RPs). It was…”
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Characterization of Iron Metabolism in Mouse Model of Congenital Polycythemia with Human Gain-of-Function Erythropoietin Receptor
Published in Blood (08-12-2017)“…Hepcidin (encoded by HAMP), the peptide hormone regulating systemic iron homeostasis, controls iron flux to plasma and thus ensures adequate iron supply for…”
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Pathophysiology of Obstructive Sleep Apnea (OSA) - Blood Cells' Reactive Oxygen Species and Inflammation Prevent Polycythemia
Published in Blood (29-11-2018)“…Obstructive sleep apnea (OSA), characterized by intermittent hypoxia, causes cardiovascular, metabolic, neurocognitive and cancer complications. Hypoxia…”
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9
Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia
Published in Blood (08-09-2016)“…The role of somatic JAK2 mutations in clonal myeloproliferative neoplasms (MPNs) is well established. Recently, germ line JAK2 mutations were associated with…”
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10
Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor
Published in Journal of molecular medicine (Berlin, Germany) (01-05-2016)“…Mutations of the truncated cytoplasmic domain of human erythropoietin receptor (EPOR) result in gain-of-function of erythropoietin (EPO) signaling and a…”
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11
Polycythemia of Mice with Human Gain-of-Function EPOR (mtHEPOR) Is Transiently Corrected in Perinatal Life in Association with Low Epo and Increased Erythrocyte Phosphatidylserine Exposure
Published in Blood (03-12-2015)“…Gain-of-function mutations of erythropoietin receptor (EPOR) resulting from truncation of the cytoplasmic domain of EPOR are associated with primary familial…”
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12
JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils
Published in Blood (29-11-2018)“…The clinical consequences of the highly prevalent JAK2 V617F mutation in Ph-negative myeloproliferative neoplasms (MPNs) are well studied. However, the impact…”
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13
Cooccurring JAK2 V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms
Published in Blood (20-12-2018)Get full text
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14
Factors influencing the selected body parameters and hippometric indexes in donkey's population
Published in Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis (2012)“…The main focus of our work was to collect basic body measurements of donkey population in Czech republic and determine the factors that influence these body…”
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