Search Results - "Kraiss, L W"

Protein synthesis by platelets: historical and new perspectives by WEYRICH, A. S., SCHWERTZ, H., KRAISS, L. W., ZIMMERMAN, G. A.

“…In the late 1960s, numerous investigators independently demonstrated that platelets are capable of synthesizing proteins. Studies continued at a steady pace…”
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Increased Blood Flow Inhibits Neointimal Hyperplasia in Endothelialized Vascular Grafts by Kohler, Ted R, Kirkman, Thomas R, Kraiss, Larry W, Zierler, Brenda K, Clowes, Alexander W

“…Intimal hyperplasia is a primary cause of failure after vascular reconstruction and may be affected by blood flow. We have studied the effects of increased…”
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Non‐genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets by Rondina, M. T., Freitag, M., Pluthero, F. G., Kahr, W. H. A., Rowley, J. W., Kraiss, L. W., Franks, Z., Zimmerman, G. A., Weyrich, A. S., Schwertz, H.

“…Essentials Platelets employ proteins/signaling pathways traditionally thought reserved for nuclear niche. We determined retinoic‐acid‐receptor alpha (RARα)…”
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An assessment of the current applicability of the EVT endovascular graft for treatment of patients with an infrarenal abdominal aortic aneurysm by Treiman, Gerald S., Lawrence, Peter F., Edwards, William H., Galt, Spencer W., Kraiss, Larry W., Bhirangi, Kiran

“…Objective: To determine the percentage of elective abdominal aortic aneurysms (AAAs)/aortoiliac aneurysms that currently can be repaired with endovascular…”
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Acute Reductions in Blood Flow and Shear Stress Induce Platelet-Derived Growth Factor-A Expression in Baboon Prosthetic Grafts by Kraiss, Larry W, Geary, Randolph L, Mattsson, Erney J.R, Vergel, Selina, Au, Y.P. Tina, Clowes, Alexander W

“…Abrupt reductions in fluid shear stress induce subendothelial smooth muscle cells (SMCs) to proliferate in experimental prosthetic grafts. Platelet-derived…”
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Short-stay carotid endarterectomy is safe and cost-effective by Kraiss, Larry W., Kilberg, Laura, Critch, Sheila, Johansen, Kaj H.

“…Carotid endarterectomy (CEA) is conventionally performed following a contrast arteriogram, under general anesthesia, and with postoperative admission to an…”
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Revision of reversed infrainguinal bypass grafts without preoperative arteriography by TREIMAN, G. S, LAWRENCE, P. F, GALT, S. W, KRAISS, L. W

“…To determine whether graft revision on the basis of a duplex scan alone without an arteriogram is effective in identifying graft stenosis and allowing for…”
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Is smooth muscle growth in primate arteries regulated by endothelial nitric oxide synthase? by Mattsson, Erney J.R., Geary, Randolph L., Kraiss, Larry W., Vergel, Selina, Liao, James K., Corson, Marshall A., Au, Y.P.Tina, Hanson, Stephen R., Clowes, Alexander W.

“…Purpose: We investigated whether control of constitutive endothelial cell nitric oxide synthase (cNOS) and nitric oxide (NO) by changes in shear stress might…”
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Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control by Lindemann, S, Tolley, N D, Eyre, J R, Kraiss, L W, Mahoney, T M, Weyrich, A S

“…Recent evidence from our laboratory demonstrates that platelets synthesize numerous proteins in a signal-dependent fashion (Pabla, R., Weyrich, A. S., Dixon,…”
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Differential Regulation of Matrix Metalloproteinase-9 by Monocytes Adherent to Collagen and Platelets by Galt, Spencer W, Lindemann, Stephan, Medd, Don, Allen, Loren L, Kraiss, Larry W, Harris, Estelle S, Prescott, Stephen M, McIntyre, Thomas M, Weyrich, Andrew S, Zimmerman, Guy A

“…ABSTRACT—Circulating monocytes adhere to platelets and matrix proteins at sites of vascular injury, where engagement of specific surface tethering molecules…”
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PDGFβ receptor blockade inhibits intimal hyperplasia in the baboon by HART, C. E, KRAISS, L. W, CLOWES, A. W, VERGEL, S, GILBERTSON, D, KENAGY, R, KIRKMAN, T, CRANDALL, D. L, TICKLE, S, FINNEY, H, YARRANTON, G

“…Background —We have evaluated the use of a mouse/human chimeric anti–platelet-derived growth factor-β receptor antibody in combination with heparin to inhibit…”
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Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells by Kraiss, L W, Weyrich, A S, Alto, N M, Dixon, D A, Ennis, T M, Modur, V, McIntyre, T M, Prescott, S M, Zimmerman, G A

“…Cellular phenotype is determined not only by genetic transcription but also by subsequent translation of mRNA into protein. Extracellular signals trigger…”
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Common femoral artery injury secondary to bicycle handlebar trauma by Sarfati, Mark R., Galt, Spencer W., Treiman, Gerald S., Kraiss, Larry W.

“…Blunt trauma from bicycle handlebars is associated with well-described injuries of the abdominal viscera. These injuries result from the forceful compression…”
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Flow-Induced DNA Synthesis Requires Signaling to a Translational Control Pathway by Kraiss, Larry W., Ennis, Tina M., Alto, Neal M.

“…Background. The mTOR translational control pathway that signals to the P70/P85 S6 kinase (pp70S6k) is essential for mitogenesis. We have previously shown that…”
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Pharmacologic intervention to prevent graft failure by Kraiss, L W, Johansen, K

“…Lower extremity vascular grafts, either vein or synthetic, fail for diverse reasons. Technical defects or poor surgical judgment doom a graft beyond any…”
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Shear stress regulates smooth muscle proliferation and neointimal thickening in porous polytetrafluoroethylene grafts by Kraiss, L W, Kirkman, T R, Kohler, T R, Zierler, B, Clowes, A W

“…High shear stress appears to decrease wall thickening in diseased arteries and vascular grafts. To determine if increased shear stress diminishes smooth muscle…”
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Endovascular-assisted versus conventional in situ saphenous vein bypass grafting: Cumulative patency, limb salvage, and cost results in a 39-month multicenter study by Rosenthal, David, Arous, Elias J., Friedman, Steven G., Ingegno, Michael D., Johnson, Brad L., Kraiss, Larry W., Martin, John D., Moritz, Mark W., Piano, Giancarlo, Rigdon, Edward E., Self, Stephen B., Pallos, L.Laszlo

“…Objective: In this retrospective multicenter study, the results of a minimally invasive method of endovascular-assisted in situ bypass grafting (EISB) versus…”
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Accuracy of duplex scanning for measurement of arterial volume flow by Zierler, Brenda K., Kirkman, Thomas R., Kraiss, Larry W., Reiss, William G., Horn, John R., Bauer, Larry A., Clowes, Alexander W., Kohler, Ted R.

“…This study examined the accuracy of duplex ultrasound measurements of volume flow in a baboon model. Volume flow (Vf) through the external iliac artery was…”
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Regional expression of the platelet-derived growth factor and its receptors in a primate graft model of vessel wall assembly by Kraiss, L W, Raines, E W, Wilcox, J N, Seifert, R A, Barrett, T B, Kirkman, T R, Hart, C E, Bowen-Pope, D F, Ross, R, Clowes, A W

“…Healing baboon polytetrafluoroethylene grafts express PDGF mRNA in the neointima. Perfusates of graft segments also contain PDGF-like mitogenic activity. To…”
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Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets by Denis, Melvin M., Tolley, Neal D., Bunting, Michaeline, Schwertz, Hansjörg, Jiang, Huimiao, Lindemann, Stephan, Yost, Christian C., Rubner, Frederick J., Albertine, Kurt H., Swoboda, Kathryn J., Fratto, Carolyn M., Tolley, Emilysa, Kraiss, Larry W., McIntyre, Thomas M., Zimmerman, Guy A., Weyrich, Andrew S.

“…Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts. We report that platelets unexpectedly possess a functional…”
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