Search Results - "Krahn, Daniel"

A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana by Meesters, Christian, Mönig, Timon, Oeljeklaus, Julian, Krahn, Daniel, Westfall, Corey S, Hause, Bettina, Jez, Joseph M, Kaiser, Markus, Kombrink, Erich

“…Jasmonate derivatives regulate numerous defense and developmental pathways in plants. A chemical screen in Arabidopsis thaliana identifies jarin-1 as an…”
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The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins) by Krahn, Daniel, Ottmann, Christian, Kaiser, Markus

“…Syrbactin is a subordinate term for the syringolin, glidobactin and cepafungin natural product families. Their grouping is based on their related molecular…”
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Triazine Probes Target Ascorbate Peroxidases in Plants by Morimoto, Kyoko, Cole, Kyle S, Kourelis, Jiorgos, Witt, Collin H, Brown, Daniel, Krahn, Daniel, Stegmann, Monika, Kaschani, Farnusch, Kaiser, Markus, Burton, Jonathan, Mohammed, Shabaz, Yamaguchi-Shinozaki, Kazuko, Weerapana, Eranthie, van der Hoorn, Renier A L

“…Though they are rare in nature, anthropogenic 1,3,5-triazines have been used in herbicides as chemically stable scaffolds. Here, we show that small…”
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Activity-based probes trap early active intermediates during metacaspase activation by Štrancar, Vida, van Midden, Katarina P., Krahn, Daniel, Morimoto, Kyoko, Novinec, Marko, Funk, Christiane, Stael, Simon, Schofield, Christopher J., Klemenčič, Marina, van der Hoorn, Renier A.L.

“…Metacaspases are essential cysteine proteases present in plants, fungi, and protists that are regulated by calcium binding and proteolytic maturation through…”
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Proteasome Activity Imaging and Profiling Characterizes Bacterial Effector Syringolin A by Kolodziejek, Izabella, Misas-Villamil, Johana C., Kaschani, Farnusch, Clerc, Jérôme, Gu, Christian, Krahn, Daniel, Niessen, Sherry, Verdoes, Martijn, Willems, Lianne I., Overkleeft, Hermen S., Kaiser, Markus, van der Hoorn, Renier A.L.

“…Syringolin A (SylA) is a nonribosomal cyclic peptide produced by the bacterial pathogen Pseudomonas syringae pv syringae that can inhibit the eukaryotic…”
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Enzymatic Timing and Tailoring of Macrolactamization in Syringolin Biosynthesis by Wuest, William M, Krahn, Daniel, Kaiser, Markus, Walsh, Christopher T

“…The enzymatic activation of 3,4-dehydrolysine and subsequent formation of the 12-membered syringolin macrolactam were investigated. The timing of the…”
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Extracellular proteolytic cascade in tomato activates immune protease Rcr3 by Paulus, Judith K., Kourelis, Jiorgos, Ramasubramanian, Selva, Homma, Felix, Godson, Alice, Hörger, Anja C., Hong, Tram Ngoc, Krahn, Daniel, Carballo, Laura Ossorio, Wang, Shuaishuai, Win, Joe, Smoker, Matthew, Kamoun, Sophien, Dong, Suomeng, van der Hoorn, Renier A. L.

“…Proteolytic cascades regulate immunity and development in animals, but these cascades in plants have not yet been reported. Here we report that the…”
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Multi-omics approaches to study platelet mechanisms by Solari, Fiorella A., Krahn, Daniel, Swieringa, Frauke, Verhelst, Steven, Rassaf, Tienush, Tasdogan, Alpaslan, Zahedi, Rene P., Lorenz, Kristina, Renné, Thomas, Heemskerk, Johan W.M., Sickmann, Albert

“…Platelets are small anucleate cell fragments (2–4 μm in diameter) in the blood, which play an essential role in thrombosis and hemostasis. Genetic or acquired…”
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Activity‐based proteomics uncovers suppressed hydrolases and a neo‐functionalised antibacterial enzyme at the plant–pathogen interface by Sueldo, Daniela J., Godson, Alice, Kaschani, Farnusch, Krahn, Daniel, Kessenbrock, Till, Buscaill, Pierre, Schofield, Christopher J., Kaiser, Markus, Hoorn, Renier A. L.

“…Summary The extracellular space of plant tissues contains hundreds of hydrolases that might harm colonising microbes. Successful pathogens may suppress these…”
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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors by Brem, Jürgen, Panduwawala, Tharindi, Hansen, Jon Ulf, Hewitt, Joanne, Liepins, Edgars, Donets, Pawel, Espina, Laura, Farley, Alistair J. M., Shubin, Kirill, Campillos, Gonzalo Gomez, Kiuru, Paula, Shishodia, Shifali, Krahn, Daniel, Leśniak, Robert K., Schmidt (Adrian), Juliane, Calvopiña, Karina, Turrientes, María-Carmen, Kavanagh, Madeline E., Lubriks, Dmitrijs, Hinchliffe, Philip, Langley, Gareth W., Aboklaish, Ali F., Eneroth, Anders, Backlund, Maria, Baran, Andrei G., Nielsen, Elisabet I., Speake, Michael, Kuka, Janis, Robinson, John, Grinberga, Solveiga, Robinson, Lindsay, McDonough, Michael A., Rydzik, Anna M., Leissing, Thomas M., Jimenez-Castellanos, Juan Carlos, Avison, Matthew B., Da Silva Pinto, Solange, Pannifer, Andrew D., Martjuga, Marina, Widlake, Emma, Priede, Martins, Hopkins Navratilova, Iva, Gniadkowski, Marek, Belfrage, Anna Karin, Brandt, Peter, Yli-Kauhaluoma, Jari, Bacque, Eric, Page, Malcolm G. P., Björkling, Fredrik, Tyrrell, Jonathan M., Spencer, James, Lang, Pauline A., Baranczewski, Pawel, Cantón, Rafael, McElroy, Stuart P., Jones, Philip S., Baquero, Fernando, Suna, Edgars, Morrison, Angus, Walsh, Timothy R., Schofield, Christopher J.

“…Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-β-lactamases (MBLs). Here we report the discovery and optimization…”
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LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B Encode Hydroxyalkyl α-Pyrone Synthases Required for Pollen Development and Sporopollenin Biosynthesis in Arabidopsis thaliana by Kim, Sung Soo, Grienenberger, Etienne, Lallemand, Benjamin, Colpitts, Che C, Kim, Sun Young, Souza, Clarice de Azevedo, Geoffroy, Pierrette, Heintz, Dimitri, Krahn, Daniel, Kaiser, Markus, Kombrink, Erich, Heitz, Thierry, Suh, Dae-Yeon, Legrand, Michel, Douglas, Carl J

“…Plant type III polyketide synthases (PKSs) catalyze the condensation of malonyl-CoA units with various CoA ester starter molecules to generate a diverse array…”
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Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family by Krahn, Daniel, Heilmann, Geronimo, Vogel, Felix C. E., Papadopoulos, Chrisovalantis, Zweerink, Susanne, Kaschani, Farnusch, Meyer, Hemmo, Roesch, Alexander, Kaiser, Markus

“…Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of Ōmura reported the constitutional…”
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Broad‐range metalloprotease profiling in plants uncovers immunity provided by defence‐related metalloenzyme by Morimoto, Kyoko, Krahn, Daniel, Kaschani, Farnusch, Hopkinson‐Woolley, Digby, Gee, Anna, Buscaill, Pierre, Mohammed, Shabaz, Sieber, Stephan A., Cravatt, Benjamin F., Schofield, Christopher J., Hoorn, Renier A. L.

“…Summary Plants encode > 100 metalloproteases representing > 19 different protein families. Tools to study this large and diverse class of proteases have not…”
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The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1‐subfamily of nitrilases by Woude, Lennard, Piotrowski, Markus, Klaasse, Gruson, Paulus, Judith K., Krahn, Daniel, Ninck, Sabrina, Kaschani, Farnusch, Kaiser, Markus, Novák, Ondřej, Ljung, Karin, Bulder, Suzanne, Verk, Marcel, Snoek, Basten L., Fiers, Martijn, Martin, Nathaniel I., Hoorn, Renier A. L., Robert, Stéphanie, Smeekens, Sjef, Zanten, Martijn

“…SUMMARY Temperature passively affects biological processes involved in plant growth. Therefore, it is challenging to study the dedicated temperature signalling…”
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Triazine Probes Target Ascorbate Peroxidases in Plants1 by Morimoto, Kyoko, Cole, Kyle S., Kourelis, Jiorgos, Witt, Collin H., Brown, Daniel, Krahn, Daniel, Stegmann, Monika, Kaschani, Farnusch, Kaiser, Markus, Burton, Jonathan, Mohammed, Shabaz, Yamaguchi-Shinozaki, Kazuko, Weerapana, Eranthie, van der Hoorn, Renier A.L.

“…3,5-triazines label and inhibit ascorbate peroxidases (APXs) in plants, revealing that triazine herbicides and their degradation products block APXs and reduce…”
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The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity by Clerc, Jérôme, Li, Nan, Krahn, Daniel, Groll, Michael, Bachmann, André S, Florea, Bogdan I, Overkleeft, Herman S, Kaiser, Markus

“…The preparation of a Syringolin A/Glidobactin A hybrid (SylA-GlbA) consisting of a SylA macrocycle connected to the GlbA side chain and its potent proteasome…”
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Regioselective Functionalization of 3-Hydroxy-pyridine Carboxylates by Neighboring Group Assistance by Wojtas, K. Philip, Lu, Jin-Yong, Krahn, Daniel, Arndt, Hans-Dieter

“…Regioselective hydrolysis, transesterification, and aminolysis of unactivated, highly substituted pyridine esters were realized under mild conditions by…”
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Identification of a Selective, Activity-Based Probe for Glyceraldehyde 3-Phosphate Dehydrogenases by Kaschani, Farnusch, Clerc, Jérôme, Krahn, Daniel, Bier, David, Hong, Tram Ngoc, Ottmann, Christian, Niessen, Sherry, Colby, Tom, van der Hoorn, Renier A. L., Kaiser, Markus

“…Exceptionally specific: The natural‐product‐like structural complexity of a bicyclic hydantoin was exploited to generate the novel, highly specific…”
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Triazine Probes Target Ascorbate Peroxidases in Plants by Morimoto, Kyoko, Cole, Kyle S, Kourelis, Jiorgos, Witt, Collin H, Brown, Daniel, Krahn, Daniel, Stegmann, Monika, Kaschani, Farnusch, Kaiser, Markus, Burton, Jonathan, Mohammed, Shabaz, Yamaguchi-Shinozaki, Kazuko, Weerapana, Eranthie, van der Hoorn, Renier A L

“…Though they are rare in nature, anthropogenic 1,3,5-triazines have been used in herbicides as chemically stable scaffolds. Here, we show that small…”
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Proteasome Activity Imaging and Profiling Characterizes Bacterial Effector Syringolin A1[W] by Kolodziejek, Izabella, Misas-Villamil, Johana C, Kaschani, Farnusch, Clerc, Jérôme, Gu, Christian, Krahn, Daniel, Niessen, Sherry, Verdoes, Martijn, Willems, Lianne I, Overkleeft, Hermen S, Kaiser, Markus, van der Hoorn, Renier A L

“…Syringolin A (SylA) is a nonribosomal cyclic peptide produced by the bacterial pathogen Pseudomonas syringae pv syringae that can inhibit the eukaryotic…”
Get full text