Search Results - "Krafte, Douglas"

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels by McCormack, Ken, Santos, Sonia, Chapman, Mark L, Krafte, Douglas S, Marron, Brian E, West, Christopher W, Krambis, Michael J, Antonio, Brett M, Zellmer, Shannon G, Printzenhoff, David, Padilla, Karen M, Lin, Zhixin, Wagoner, P Kay, Swain, Nigel A, Stupple, Paul A, de Groot, Marcel, Butt, Richard P, Castle, Neil A

“…Voltage-gated sodium (Na ᵥ) channels play a fundamental role in the generation and propagation of electrical impulses in excitable cells. Here we describe two…”
Get full text

A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy by Atkin, Talia A., Maher, Chani M., Gerlach, Aaron C., Gay, Bryant C., Antonio, Brett M., Santos, Sonia C., Padilla, Karen M., Rader, JulieAnn, Krafte, Douglas S., Fox, Matthew A., Stewart, Gregory R., Petrovski, Slavé, Devinsky, Orrin, Might, Matthew, Petrou, Steven, Goldstein, David B.

“…Summary Objective Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds…”
Get full text

A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats by Zhang, Xu-Feng, Shieh, Char-Chang, Chapman, Mark L, Matulenko, Mark A, Hakeem, Ahmed H, Atkinson, Robert N, Kort, Michael E, Marron, Brian E, Joshi, Shailen, Honore, Prisca, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F

“…Activation of sodium channels is essential to action potential generation and propagation. Recent genetic and pharmacological evidence indicates that…”
Get full text

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat by Jarvis, Michael F, Honore, Prisca, Shieh, Char-Chang, Chapman, Mark, Joshi, Shailen, Zhang, Xu-Feng, Kort, Michael, Carroll, William, Marron, Brian, Atkinson, Robert, Thomas, James, Liu, Dong, Krambis, Michael, Liu, Yi, McGaraughty, Steve, Chu, Katharine, Roeloffs, Rosemarie, Zhong, Chengmin, Mikusa, Joseph P, Hernandez, Gricelda, Gauvin, Donna, Wade, Carrie, Zhu, Chang, Pai, Madhavi, Scanio, Marc, Shi, Lei, Drizin, Irene, Gregg, Robert, Matulenko, Mark, Hakeem, Ahmed, Gross, Michael, Johnson, Matthew, Marsh, Kennan, Wagoner, P. Kay, Sullivan, James P, Faltynek, Connie R, Krafte, Douglas S

“…Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed…”
Get full text

Sodium channels and nociception: recent concepts and therapeutic opportunities by Krafte, Douglas S, Bannon, Anthony W

“…Recent scientific advances have enhanced our understanding of the role voltage-gated sodium channels play in pain sensation. Human data on Nav1.7 show that…”
Get full text

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain by Kort, Michael E, Drizin, Irene, Gregg, Robert J, Scanio, Marc J. C, Shi, Lei, Gross, Michael F, Atkinson, Robert N, Johnson, Matthew S, Pacofsky, Gregory J, Thomas, James B, Carroll, William A, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C, Murray, Bernard P, Liu, Jinrong, Werness, Stephen, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Chapman, Mark L, Marron, Brian E

“…Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons…”
Get full text

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain by Scanio, Marc J C, Shi, Lei, Drizin, Irene, Gregg, Robert J, Atkinson, Robert N, Thomas, James B, Johnson, Matthew S, Chapman, Mark L, Liu, Dong, Krambis, Michael J, Liu, Yi, Shieh, Char-Chang, Zhang, Xufeng, Simler, Gricelda H, Joshi, Shailen, Honore, Prisca, Marsh, Kennan C, Knox, Alison, Werness, Stephen, Antonio, Brett, Krafte, Douglas S, Jarvis, Michael F, Faltynek, Connie R, Marron, Brian E, Kort, Michael E

“…Na(v)1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory…”
Get full text

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain by SCANIO, Marc J. C, LEI SHI, YI LIU, SHIEH, Char-Chang, XUFENG ZHANG, SIMLER, Gricelda H, JOSHI, Shailen, HONORE, Prisca, MARSH, Kennan C, KNOX, Alison, WERNESS, Stephen, ANTONIO, Brett, DRIZIN, Irene, KRAFTE, Douglas S, JARVIS, Michael F, FALTYNEK, Connie R, MARRON, Brian E, KORT, Michael E, GREGG, Robert J, ATKINSON, Robert N, THOMAS, James B, JOHNSON, Matthew S, CHAPMAN, Mark L, DONG LIU, KRAMBIS, Michael J

Get full text

Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives by Kort, Michael E, Atkinson, Robert N, Thomas, James B, Drizin, Irene, Johnson, Matthew S, Secrest, Matthew A, Gregg, Robert J, Scanio, Marc J C, Shi, Lei, Hakeem, Ahmed H, Matulenko, Mark A, Chapman, Mark L, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Marron, Brian E

“…A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na(v)1.8 sodium channel is reported. Replacement of the…”
Get full text

The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons by Su, Xin, Castle, Neil A., Antonio, Brett, Roeloffs, Rosemarie, Thomas, James B., Krafte, Douglas S., Chapman, Mark L.

“…A non-opioid receptor-mediated inhibition of sodium channels in dorsal root ganglia (DRGs) by kappa-opioid receptor agonists (kappa-ORAs) has been reported to…”
Get full text

Ion channels: applications in ion channel drug discovery by Krafte, Douglas S

Get more information

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives by Kort, Michael E., Atkinson, Robert N., Thomas, James B., Drizin, Irene, Johnson, Matthew S., Secrest, Matthew A., Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Hakeem, Ahmed H., Matulenko, Mark A., Chapman, Mark L., Krambis, Michael J., Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Simler, Gricelda, Mikusa, Joseph P., Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Werness, Stephen, Antonio, Brett, Marsh, Kennan C., Faltynek, Connie R., Krafte, Douglas S., Jarvis, Michael F., Marron, Brian E.

“…A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Nav1.8 sodium channel is reported. Replacement of the…”
Get full text

Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K + channel hKir2.3 by Liu, Yi, Liu, Dong, Printzenhoff, David, Coghlan, Michael J., Harris, Richard, Krafte, Douglas S.

“…We studied the effect of a novel anti-inflammatory agent, tenidap, on a cloned inwardly rectifying K + channel, hKir2.3. Tenidap (a) potently potentiated 86Rb…”
Get full text

Prevention of Proteinuria by a Novel, Subnanomolar ApoL1 Inhibitor: FR-OR105 by Antonio, Brett M., Zahler, Nathan, Mechin, Ingrid, Theile, Jonathan W., Dow, Robert L., Volkmann, Robert A., Zellmer, Shannon G., Chdid, Lhoucine, Nair, Anil, Krafte, Douglas

Get full text

Block of Nav1.8 by Small Molecules by Krafte, Douglas S., Chapman, Mark, Marron, Brian, Atkinson, Robert, Liu, Yi, Yu, Fei, Kort, Michael, Jarvis, Michael F.

“…Sodium channels are key proteins in regulating neuronal excitability and accumulating data suggest that specific subtypes of voltage-dependent sodium channels…”
Get full text

Decrease of inward rectification as a mechanism for arachidonic acid-induced potentiation of hKir2.3 by Liu, Yi, Liu, Dong, Krafte, Douglas S

“…Previously, we showed that arachidonic acid (AA) potentiates currents flowing through a cloned human inwardly rectifying K(+) channel, hKir2.3. The mechanism…”
Get full text

APOL1 G1-Mediated Cation Transport Inhibits Amino Acid Transport and Increases Endoplasmic Reticulum Calcium Release, Causing Podocytopathy: SA-PO985 by Olabisi, Opeyemi A., Datta, Somenath, Antonio, Brett M., Zahler, Nathan, Krafte, Douglas, Hohmeier, Hans-Ewald, Chaves, Alec, Nystrom, Sarah, Zhang, Guofang, Ilkayeva, Olga, Silas, Daniel P., Theile, Jonathan W., Muehlbauer, Michael, Becker, Thomas C., Li, Guojie, Bain, James R., Soldano, Karen, Newgard, Christopher B.

Get full text

Synthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels by Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Carabateas, Philip M, Rumney, Squire, Pilling, Garry M, Krafte, Douglas S, Volberg, Walter A, Dillon, Kathleen, Dugrenier, Nancy, Briggs, G. Maurice, Canniff, Paul C, Gorczyca, William P, Stankus, Gerald P, Ezrin, Alan M

“…Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in…”
Get full text

Direct activation of an inwardly rectifying potassium channel by arachidonic acid by Liu, Y, Liu, D, Heath, L, Meyers, D M, Krafte, D S, Wagoner, P K, Silvia, C P, Yu, W, Curran, M E

“…Arachidonic acid (AA) is an important constituent of membrane phospholipids and can be liberated by activation of cellular phospholipases. AA modulates a…”
Get more information

A comprehensive approach to identifying repurposed drugs to treat SCN 8A epilepsy by Atkin, Talia A., Maher, Chani M., Gerlach, Aaron C., Gay, Bryant C., Antonio, Brett M., Santos, Sonia C., Padilla, Karen M., Rader, JulieAnn, Krafte, Douglas S., Fox, Matthew A., Stewart, Gregory R., Petrovski, Slavé, Devinsky, Orrin, Might, Matthew, Petrou, Steven, Goldstein, David B.

“…Summary Objective Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds…”
Get full text