Search Results - "Krafte, D S"

A Neutral Amino Acid Change in Segment IIS4 Dramatically Alters the Gating Properties of the Voltage-Dependent Sodium Channel by Auld, V. J., Goldin, A. L., Krafte, D. S., Catterall, W. A., Lester, H. A., Davidson, N., Dunn, R. J.

“…Sodium channels encoded by the rat IIA cDNA clone [Auld, V. J., Goldin, A. L., Krafte, D. S., Marshall, J., Dunn, J., Catterall, W. A., Lester, H. A.,…”
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Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644 by SANGUINETTI, M. C, KRAFTE, D. S, KASS, R. S

“…We have investigated the voltage-dependent effects of the dihydropyridine Bay K8644 on Ca channel currents in calf Purkinje fibers and enzymatically dispersed…”
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Identification of Three Separate Binding Sites on SHK Toxin, a Potent Inhibitor of Voltage-Dependent Potassium Channels in Human T-Lymphocytes and Rat Brain by Pennington, M.W., Mahnir, V.M., Krafte, D.S., Zaydenberg, I., Byrnes, M.E., Khaytin, I., Crowley, K., Kem, W.R.

“…Eighteen synthetic analogs of ShK toxin, a thirty-five-residue K channel blocker derived from the sea anemoneStichodactyla helianthus,were prepared in order to…”
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Sodium channels and nociception: recent concepts and therapeutic opportunities by Krafte, Douglas S, Bannon, Anthony W

“…Recent scientific advances have enhanced our understanding of the role voltage-gated sodium channels play in pain sensation. Human data on Nav1.7 show that…”
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Characterization of endogenous sodium channel gene expressed in Chinese hamster ovary cells by Lalik, P H, Krafte, D S, Volberg, W A, Ciccarelli, R B

“…Chinese hamster ovary (CHO-K1) cells were observed to display transient inward Na+ currents of average amplitude (-92 +/- 20 pA), which activated at voltages…”
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Negative surface charge density near heart calcium channels. Relevance to block by dihydropyridines by Kass, R S, Krafte, D S

“…We have measured the density of negative surface charges near the voltage sensor for inactivation gating of (L-type) Ca channels in intact calf Purkinje fibers…”
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Hydrogen ion modulation of Ca channel current in cardiac ventricular cells. Evidence for multiple mechanisms by Krafte, D S, Kass, R S

“…We have investigated the effects of H ions on (L-type) Ca channel current in isolated ventricular cells. We find that the current amplitude is enhanced in…”
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Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes by Krafte, DS, Snutch, TP, Leonard, JP, Davidson, N, Lester, HA

“…The properties of rat and rabbit brain sodium (Na) channels expressed in Xenopus oocytes following either unfractionated or high-molecular-weight mRNA…”
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Synthesis and Structure-Activity Relationships of 6-Heterocyclic-Substituted Purines as Inactivation Modifiers of Cardiac Sodium Channels by Estep, Kimberly G, Josef, Kurt A, Bacon, Edward R, Carabateas, Philip M, Rumney, Squire, Pilling, Garry M, Krafte, Douglas S, Volberg, Walter A, Dillon, Kathleen, Dugrenier, Nancy, Briggs, G. Maurice, Canniff, Paul C, Gorczyca, William P, Stankus, Gerald P, Ezrin, Alan M

“…Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in…”
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Expression of Cardiac Na Channels with Appropriate Physiological and Pharmacological Properties in Xenopus Oocytes by Krafte, D. S., Volberg, W. A., Dillon, K., Ezrin, A. M.

“…The objective of this study was to determine whether the Xenopus laevis oocyte can express an exogenous cardiac Na channel that retains its normal…”
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Pharmacological modulation of human cardiac Na+ channels by Krafte, D S, Davison, K, Dugrenier, N, Estep, K, Josef, K, Barchi, R L, Kallen, R G, Silver, P J, Ezrin, A M

“…Pharmacological modulation of human sodium current was examined in Xenopus oocytes expressing human heart Na+ channels. Na+ currents activated near -50 mV with…”
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Novel Inhibitors of Potassium Ion Channels on Human T Lymphocytes by Michne, William F, Guiles, Joseph W, Treasurywala, Adi M, Castonguay, Laurie A, Weigelt, Carolyn A, Oconnor, Bernard, Volberg, Walter A, Grant, Alison M, Chadwick, Christopher C, Krafte, Douglas S, Hill, Roger J

“…The in vitro biological characterization of a series of 4-(alkylamino)-1,4-dihydroquinolines is reported. These compounds are novel inhibitors of…”
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Inactivation of cloned Na channels expressed in Xenopus oocytes by KRAFTE, D. S, GOLDIN, A. L, AULD, V. J, DUNN, R. J, DAVIDSON, N, LESTER, H. A

“…This study investigates the inactivation properties of Na channels expressed in Xenopus oocytes from two rat IIA Na channel cDNA clones differing by a single…”
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Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone by Pennington, M W, Byrnes, M E, Zaydenberg, I, Khaytin, I, de Chastonay, J, Krafte, D S, Hill, R, Mahnir, V M, Volberg, W A, Gorczyca, W

“…ShK-toxin, a 35 residue peptide isolated from the sea anemone Stichodactyla helianthus, was synthesized using an Fmoc strategy and successfully folded to the…”
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Properties of endogenous voltage-dependent sodium currents in Xenopus laevis oocytes by Krafte, D S, Volberg, W A

“…Endogenous voltage-dependent sodium currents were recorded using standard 2-microelectrode techniques in Xenopus laevis oocytes. Maximal inward current…”
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Use of stage II-III Xenopus oocytes to study voltage-dependent ion channels by Krafte, D S, Lester, H A

“…Stage II-III Xenopus oocytes represent a useful extension of the standard Xenopus oocyte expression system. The oocytes are smaller; the reduction in membrane…”
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Direct activation of an inwardly rectifying potassium channel by arachidonic acid by Liu, Y, Liu, D, Heath, L, Meyers, D M, Krafte, D S, Wagoner, P K, Silvia, C P, Yu, W, Curran, M E

“…Arachidonic acid (AA) is an important constituent of membrane phospholipids and can be liberated by activation of cellular phospholipases. AA modulates a…”
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A rat brain Na+ channel alpha subunit with novel gating properties by Auld, V J, Goldin, A L, Krafte, D S, Marshall, J, Dunn, J M, Catterall, W A, Lester, H A, Davidson, N, Dunn, R J

“…We have constructed a full-length rat brain Na+ channel alpha subunit cDNA that differs from the previously reported alpha subunit of Noda et al. at 6 amino…”
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Voltage dependence of cardiac delayed rectifier block by methanesulfonamide class III antiarrhythmic agents by Krafte, D S, Volberg, W A

“…Voltage-clamp experiments were performed on isolated guinea pig ventricular myocytes to examine the voltage dependence of delayed rectifier block by…”
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Identification of a Specific Radioligand for the Cardiac Rapidly Activating Delayed Rectifier K+ Channel by Chadwick, Christopher C, Ezrin, Alan M, OʼConnor, Bernard, Volberg, Walter A, Smith, David I, Wedge, Karen J, Hill, Roger J, Briggs, G Maurice, Pagani, Edward D, Silver, Paul J, Krafte, Douglas S

“…Class III antiarrhythmic drugs show promise as effective treatments for the suppression of potentially lethal cardiac arrhythmias. Dofetilide (UK-68,798), is a…”
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