Search Results - "Kraft, Matthew B."

Recognition of microbial glycans by human intelectin-1 by Wesener, Darryl A, Wangkanont, Kittikhun, McBride, Ryan, Song, Xuezheng, Kraft, Matthew B, Hodges, Heather L, Zarling, Lucas C, Splain, Rebecca A, Smith, David F, Cummings, Richard D, Paulson, James C, Forest, Katrina T, Kiessling, Laura L

“…Extensive glycan microarray and structural analyses reveal that human intelectin-1 interacts selectively with microbial glycan epitopes through recognition of…”
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The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line by Kedei, Noemi, Telek, Andrea, Czap, Alexandra, Lubart, Emanuel S., Czifra, Gabriella, Yang, Dazhi, Chen, Jinqiu, Morrison, Tyler, Goldsmith, Paul K., Lim, Langston, Mannan, Poonam, Garfield, Susan H., Kraft, Matthew B., Li, Wei, Keck, Gary E., Blumberg, Peter M.

“…Bryostatin 1 has attracted considerable attention both as a cancer chemotherapeutic agent and for its unique activity. Although it functions, like phorbol…”
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Biosynthetic Glycan Labeling by Marando, Victoria M, Kim, Daria E, Calabretta, Phillip J, Kraft, Matthew B, Bryson, Bryan D, Kiessling, Laura L

“…Glycans are ubiquitous and play important biological roles, yet chemical methods for probing their structure and function within cells remain limited…”
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Bacterial Cell Wall Modification with a Glycolipid Substrate by Calabretta, Phillip J, Hodges, Heather L, Kraft, Matthew B, Marando, Victoria M, Kiessling, Laura L

“…Despite the ubiquity and importance of glycans in biology, methods to probe their structures in cells are limited. Mammalian glycans can be modulated using…”
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Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core by Kraft, Matthew B, Poudel, Yam B, Kedei, Noemi, Lewin, Nancy E, Peach, Megan L, Blumberg, Peter M, Keck, Gary E

“…A convergent synthesis of a des-B-ring bryostatin analogue is described. This analogue was found to undergo an unexpected ring expansion of the bryolactone…”
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A Path to Complex Carbohydrates by Kiessling, Laura L., Kraft, Matthew B.

“…A general strategy for synthesizing asymmetrically branched carbohydrates will help to elucidate their biological functions. [Also see Report by Wang et al. ]…”
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The Bryostatin 1 A-Ring Acetate is Not the Critical Determinant for Antagonism of Phorbol Ester-Induced Biological Responses by Keck, Gary E, Li, Wei, Kraft, Matthew B, Kedei, Noemi, Lewin, Nancy E, Blumberg, Peter M

“…The contribution of the A-ring C7 acetate to the function of bryostatin 1 has been investigated through synthesis and biological evaluation of an analogue…”
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Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure–Function Relationships by Kedei, Noemi, Kraft, Matthew B, Keck, Gary E, Herald, Cherry L, Melody, Noeleen, Pettit, George R, Blumberg, Peter M

“…Bryostatin 1, a complex macrocyclic lactone isolated from Bugula neritina, has been the subject of multiple clinical trials for cancer. Although it functions…”
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Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function by Keck, Gary E, Kraft, Matthew B, Truong, Anh P, Li, Wei, Sanchez, Carina C, Kedei, Noemi, Lewin, Nancy E, Blumberg, Peter M

“…Highly potent bryostatin analogues which contain the complete bryostatin core structure have been synthesized using a pyran annulation approach as a key…”
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Synthesis of Lipid-Linked Arabinofuranose Donors for Glycosyltransferases by Kraft, Matthew B, Martinez Farias, Mario A, Kiessling, Laura L

“…Mycobacteria and corynebacteria use decaprenylphosphoryl-β-d-arabinofuranose (DPA) as a critical cell wall building block. Arabinofuranosyltransferases that…”
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Total Synthesis of Epothilones B and D: Stannane Equivalents for β-Keto Ester Dianions by Keck, Gary E, Giles, Robert L, Cee, Victor J, Wager, Carrie A, Yu, Tao, Kraft, Matthew B

“…Studies leading to a total synthesis of epothilones B and D are described. The overall synthetic plan was based on late-stage fragment assembly of two segments…”
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Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters by Keck, Gary E, Poudel, Yam B, Welch, Dennie S, Kraft, Matthew B, Truong, Anh P, Stephens, Jeffrey C, Kedei, Noemi, Lewin, Nancy E, Blumberg, Peter M

“…A close structural analogue of bryostatin 1, which differs from bryostatin 1 only by the absence of the C30 carbomethoxy group (on the C13 enoate of the…”
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Some Phorbol Esters Might Partially Resemble Bryostatin 1 in their Actions on LNCaP Prostate Cancer Cells and U937 Leukemia Cells by Kedei, Noemi, Lubart, Emanuel, Lewin, Nancy E., Telek, Andrea, Lim, Langston, Mannan, Poonam, Garfield, Susan H., Kraft, Matthew B., Keck, Gary E., Kolusheva, Sofiya, Jelinek, Raz, Blumberg, Peter M.

“…Phorbol 12‐myristate 13‐acetate (PMA) and bryostatin 1 are both potent protein kinase C (PKC) activators. In LNCaP human prostate cancer cells, PMA induces…”
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Bacterial cell wall modification by glycolipid probes by Marando, Victoria M., Calabretta, Phillip J., Hodges, Heather L., Kraft, Matthew B., Kim, Daria E., Kiessling, Laura L.

“…Abstract only…”
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Recognition of Microbial Glycans by Human Intelectin by Wesener, Darryl A., Wangkanont, Kittikhun, McBride, Ryan, Song, Xuezheng, Kraft, Matthew B., Hodges, Heather L., Zarling, Lucas C., Splain, Rebecca A., Smith, David F., Cummings, Richard D., Paulson, James C., Forest, Katrina T., Kiessling, Laura L.

“…The glycans displayed on mammalian cells can differ markedly from those on microbes. Such differences could, in principle, be read by carbohydrate-binding…”
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Chemistry. A path to complex carbohydrates by Kiessling, Laura L, Kraft, Matthew B

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Abstract 3815: Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogues in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action by Kedei, Noemi, Telek, Andrea, Michalowski, Aleksandra M., Kraft, Matthew B., Li, Wei, Poudel, Yam B., Rudra, Arnab, Petersen, Mark E., Keck, Gary E., Blumberg, Peter M.

“…Bryostatin 1 has attracted great interest as a cancer chemotherapeutic agent with a unique mechanism of action. Whereas bryostatin 1 binds to and activates…”
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Some phorbol esters may partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells by Kedei, Noemi, Lubart, Emanuel, Lewin, Nancy E., Telek, Andrea, Lim, Langston, Mannan, Poonam, Garfield, Susan H., Kraft, Matthew B., Keck, Gary E., Kolusheva, Sofiya, Jelinek, Raz, Blumberg, Peter M.

“…Phorbol 12-myristate 13-acetate (PMA) and bryostatin 1 are both potent protein kinase C (PKC) activators. In LNCaP human prostate cancer cells, PMA induces…”
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