Search Results - "Kraemer, Lauren D."

A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results by Rappaport, Amy R., Kyi, Chrisann, Lane, Monica, Hart, Meghan G., Johnson, Melissa L., Henick, Brian S., Liao, Chih-Yi, Mahipal, Amit, Shergill, Ardaman, Spira, Alexander I., Goldman, Jonathan W., Scallan, Ciaran D., Schenk, Desiree, Palmer, Christine D., Davis, Matthew J., Kounlavouth, Sonia, Kemp, Lindsey, Yang, Aaron, Li, Yaojun John, Likes, Molly, Shen, Annie, Boucher, Gregory R., Egorova, Milana, Veres, Robert L., Espinosa, J. Aaron, Jaroslavsky, Jason R., Kraemer Tardif, Lauren D., Acrebuche, Lindsey, Puccia, Christopher, Sousa, Leiliane, Zhou, Rita, Bae, Kyounghwa, Hecht, J. Randolph, Carbone, David P., Johnson, Benny, Allen, Andrew, Ferguson, Andrew R., Jooss, Karin

“…Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific neoantigens hold promise for providing long-term clinical benefit to…”
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GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults by Palmer, Christine D., Scallan, Ciaran D., Kraemer Tardif, Lauren D., Kachura, Melissa A., Rappaport, Amy R., Koralek, Daniel O., Uriel, Alison, Gitlin, Leonid, Klein, Joshua, Davis, Matthew J., Venkatraman, Harshni, Hart, Meghan G., Jaroslavsky, Jason R., Kounlavouth, Sonia, Marrali, Martina, Nganje, Charmaine N., Bae, Kyounghwa, Yan, Tiffany, Leodones, Katharyn, Egorova, Milana, Hong, Sue-Jean, Kuan, Jenchun, Grappi, Silvia, Garbes, Pedro, Jooss, Karin, Ustianowski, Andrew

“…SARS-CoV-2 has resulted in high levels of morbidity and mortality world-wide, and severe complications can occur in older populations. Humoral immunity induced…”
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Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results by Palmer, Christine D., Rappaport, Amy R., Davis, Matthew J., Hart, Meghan G., Scallan, Ciaran D., Hong, Sue-Jean, Gitlin, Leonid, Kraemer, Lauren D., Kounlavouth, Sonia, Yang, Aaron, Smith, Lindsey, Schenk, Desiree, Skoberne, Mojca, Taquechel, Kiara, Marrali, Martina, Jaroslavsky, Jason R., Nganje, Charmaine N., Maloney, Elizabeth, Zhou, Rita, Navarro-Gomez, Daniel, Greene, Adrienne C., Grotenbreg, Gijsbert, Greer, Renee, Blair, Wade, Cao, Minh Duc, Chan, Shawn, Bae, Kyounghwa, Spira, Alexander I., Roychowdhury, Sameek, Carbone, David P., Henick, Brian S., Drake, Charles G., Solomon, Benjamin J., Ahn, Daniel H., Mahipal, Amit, Maron, Steve B., Johnson, Benny, Rousseau, Raphael, Yelensky, Roman, Liao, Chih-Yi, Catenacci, Daniel V. T., Allen, Andrew, Ferguson, Andrew R., Jooss, Karin

“…Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert…”
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CUE-101, a Novel E7-pHLA-IL2-Fc Fusion Protein, Enhances Tumor Antigen-Specific T-Cell Activation for the Treatment of HPV16-Driven Malignancies by Quayle, Steven N, Girgis, Natasha, Thapa, Dharma R, Merazga, Zohra, Kemp, Melissa M, Histed, Alex, Zhao, Fan, Moreta, Miguel, Ruthardt, Paige, Hulot, Sandrine, Nelson, Alyssa, Kraemer, Lauren D, Beal, Dominic R, Witt, Luke, Ryabin, Jessica, Soriano, Jonathan, Haydock, Mark, Spaulding, Emily, Ross, John F, Kiener, Peter A, Almo, Steven, Chaparro, Rodolfo, Seidel, Ronald, Suri, Anish, Cemerski, Saso, Pienta, Kenneth J, Simcox, Mary Ellen

“…To assess the potential for CUE-101, a novel therapeutic fusion protein, to selectively activate and expand HPV16 E7 -specific CD8 T cells as an off-the shelf…”
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Abstract 2267: HLA-DR-restricted CD4 T cell responses to KRAS G12C in healthy donors linked to bacterial mimotope: lessons for KRAS neoantigen vaccines in cancer patients by Palmer, Christine D., Hart, Meghan G., Kounlavouth, Sonia, Venkatraman, Harshni, Kraemer, Lauren D., Marrali, Martina, Dominguez, Calixto, Chowdhury, Fatema Z., Jaroslavsky, Jason R., Arcebuche, Lindsey, Hernandez, Lorenzo, Adeoye, Bukola, Cuison, Severino, Rappaport, Amy R., Boucher, Greg, Lane, Monica, Rotunno, Melissa, Avocetien, Kenneth, Sousa, Leiliane, Puccia, Chris, Likes, Molly, Vegesna, Rahul, Zhou, Rita, Mantilla, Alexis, Davis, Matthew J., Dhanik, Ankur, Johnson, Melissa, Ferguson, Andrew R., Jooss, Karin

“…Mutations in the KRAS gene are among the most common driver mutations in cancer. Targeting KRAS G12C mutations has shown some promise in clinical studies,…”
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Abstract 4159: Lower doses of self-amplifying mRNA drive superior neoantigen-specific CD8 T cell responses in cancer patients versus high doses by Palmer, Christine D., Rappaport, Amy R., Hart, Meghan G., Kraemer, Lauren D., Kounlavouth, Sonia, Marrali, Martina, Jaroslavsky, Jason R., Nganje, Charmaine N., Shen, Annie, Boucher, Gregory R., Kachura, Melissa A., Scallan, Ciaran D., Hong, Sue-Jean, Gitlin, Leonid, Spira, Alexander I., Kyi, Chrisann, Catenacci, Daniel V., Rousseau, Raphael, Ferguson, Andrew, Jooss, Karin

“…The immunogenicity and efficacy of RNA-based vaccine platforms has been abundantly shown through their application in prophylactic SARS-CoV2 vaccines…”
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Abstract 3578: Optimization of shared neoantigen vaccine design to increase vaccine potency: From bench to bedside and back by Rappaport, Amy R., Palmer, Christine D., Shen, Annie, Dominguez, Claudia X., Hart, Meghan G., Kraemer, Lauren D., Koulavouth, Sonia, Marrali, Martina, Jaroslavsky, Jason R., Nganje, Charmaine N., Scallan, Ciaran D., Hong, Sue-Jean, Gitlin, Leonid, Lane, Monica, Catenacci, Daniel V., Kyi, Chrisann, Carbone, David P., Borghaei, Hossein, Rousseau, Raphael, Ferguson, Andrew, Jooss, Karin

“…Vaccines targeting neoantigens identified from common tumor driver mutations are of increasing interest as evidence of clinical benefit builds, and…”
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