Search Results - "Kraan, M C"

Efficacy and safety of selective glucocorticoid receptor modulators in comparison to glucocorticoids in arthritis, a systematic review by Safy, M, de Hair, M J H, Jacobs, J W G, Buttgereit, F, Kraan, M C, van Laar, J M

“…Long-term treatment with glucocorticoids (GCs) plays an important role in the management of arthritis patients, although the efficacy/safety balance is…”
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Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis by Haringman, J J, Gerlag, D M, Zwinderman, A H, Smeets, T J M, Kraan, M C, Baeten, D, McInnes, I B, Bresnihan, B, Tak, P P

“…Background: Previous work identified synovial sublining macrophage numbers as a potential biomarker for clinical efficacy in rheumatoid arthritis. Objective:…”
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Clinical identification and treatment of a rapidly progressing disease state in patients with rheumatoid arthritis by Emery, P., McInnes, I. B., van Vollenhoven, R., Kraan, M. C.

“…Inflammation is the major factor driving the progression of structural damage in rheumatoid arthritis (RA); therefore, it is critical to achieve rapid…”
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The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor alpha expression in the synovium by Wijbrandts, C A, Dijkgraaf, M G W, Kraan, M C, Vinkenoog, M, Smeets, T J, Dinant, H, Vos, K, Lems, W F, Wolbink, G J, Sijpkens, D, Dijkmans, B A C, Tak, P P

“…To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by…”
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Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis by Haringman, J J, Kraan, M C, Smeets, T J M, Zwinderman, K H, Tak, P P

“…Background: Chemokines and their receptors are considered important contributors in cell migration and inflammation in chronic inflammatory disorders…”
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Activation of the STAT1 pathway in rheumatoid arthritis by Kasperkovitz, P V, Verbeet, N L, Smeets, T J, van Rietschoten, J G I, Kraan, M C, van der Pouw Kraan, T C T M, Tak, P P, Verweij, C L

“…Background: Expression of signal transducer and activator of transcription 1 (STAT1), the mediator of interferon (IFN) signalling, is raised in synovial tissue…”
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Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis by Smeets, T J M, Barg, E C, Kraan, M C, Smith, M D, Breedveld, F C, Tak, P P

“…Background: Synovial tissue (ST) from end stage destructive rheumatoid arthritis (RA) and arthroscopic biopsies obtained during active inflammation might…”
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Early effects of tumour necrosis factor α blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis by Goedkoop, A Y, Kraan, M C, Teunissen, M B M, Picavet, D I, de Rie, M A, Bos, J D, Tak, P P

“…Background: Tumour necrosis factor α (TNFα) blockade using infliximab, a chimeric anti-TNFα antibody, is an effective treatment for both psoriasis and…”
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Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis by Kraan, M C, Smeets, T J M, van Loon, M J, Breedveld, F C, Dijkmans, B A C, Tak, P P

“…Background: T cells have a pivotal role in RA. Leflunomide inhibits pyrimidine biosynthesis, to which T cells are especially susceptible, and therefore may…”
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Validation of shoe-worn Gait Up Physilog®5 wearable inertial sensors in adolescents by Carroll, K., Kennedy, R.A., Koutoulas, V., Bui, M., Kraan, C.M.

“…•Performance of the Physilog® sensor in children was high.•Best performance was observed for stride time.•The Physilog® sensors have potential clinical and…”
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Immunohistological analysis of synovial tissue for differential diagnosis in early arthritis by Kraan, M. C., Haringman, J. J., Post, W. J., Versendaal, J., Breedveld, F. C., Tak, P. P.

“…Objective. An early diagnosis in patients presenting with arthritis is important to provide information about prognosis and to initiate treatment. The…”
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Tumour necrosis factor α blockade in treatment resistant pigmented villonodular synovitis by Kroot, E-J A, Kraan, M C, Smeets, T J M, Maas, M, Tak, P P, Wouters, J M G W

“…Background: Pigmented villonodular synovitis (PVNS) is considered to be a neoplastic-like disorder of the synovium histologically characterised by villonodular…”
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Quantification of the cell infiltrate in synovial tissue by digital image analysis by Kraan, M. C., Haringman, J. J., Ahern, M. J., Breedveld, F. C., Smith, M. D., Tak, P. P.

“…Objective. The experience with digital image analysis (DIA) in the assessment of synovial inflammation is limited. In this study we compared DIA with two…”
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Comparability between wearable inertial sensors and an electronic walkway for spatiotemporal and relative phase data in young children aged 6–11 years by Carroll, K., Kennedy, R.A., Koutoulas, V., Werake, U., Bui, M., Kraan, C.M.

“…Approaches to gait analysis are evolving rapidly and now include a wide range of options: from e-patches to video platforms to wearable inertial measurement…”
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T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis by Kraan, M C, Haringman, J J, Weedon, H, Barg, E C, Smith, M D, Ahern, M J, Smeets, T J M, Breedveld, F C, Tak, P P

“…Objective: To determine immunohistological markers in synovial tissue of patients with early rheumatoid arthritis (RA) which are associated with unfavourable…”
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The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA) by TAK, P. P, SPAENY-DEKKING, L, KRAAN, M. C, BREEDVELD, F. C, FROELICH, C. J, HACK, C. E

“…Cytotoxic cells possess specialized granules which contain perforin and a group of serine proteinases termed granzymes. Granzyme‐positive cells have been…”
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Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA by Smeets, T J M, Kraan, M C, Galjaard, S, Youssef, P P, Smith, M D, Tak, P P

“…OBJECTIVES Examination of synovial tissue (ST) obtained at surgery because of end stage destructive rheumatoid arthritis (RA) showed that macrophages and…”
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Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids by Jahangier, Z N, Jacobs, J W G, Kraan, M C, Wenting, M J G, Smeets, T J, Bijlsma, J W J, Lafeber, F P J G, Tak, P P

“…Objective: To explore whether pretreatment features of synovial tissue in patients with gonarthritis could predict the clinical effect of radiation synovectomy…”
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The developmental dynamics of gait maturation with a focus on spatiotemporal measures by Kraan, C.M, Tan, A.H.J, Cornish, K.M

“…Highlights • Studies of gait maturation provide insight into brain function. • We review the neural processes contributing to and regulating gait in children…”
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Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases by de Jong, Tamarah D, Vosslamber, Saskia, Mantel, Elise, de Ridder, Sander, Wesseling, John G, van der Pouw Kraan, Tineke C T M, Leurs, Cyra, Hegen, Harald, Deisenhammer, Florian, Killestein, Joep, Lundberg, Ingrid E, Vencovsky, Jiri, Nurmohamed, Mike T, van Schaardenburg, Dirkjan, Bultink, Irene E M, Voskuyl, Alexandre E, Pegtel, D Michiel, van der Laken, Conny J, Bijlsma, Johannes W J, Verweij, Cornelis L

“…Activation of the type I interferon (IFN) response program is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple…”
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